1,3-Dibromo-5-chlorobenzene
- Product Name
- 1,3-Dibromo-5-chlorobenzene
- CAS No.
- 14862-52-3
- Chemical Name
- 1,3-Dibromo-5-chlorobenzene
- Synonyms
- 1-CHLORO-3,5-DIBROMOBENZENE;3,5-DIBROMOCHLOROBENZENE;Fluralaner-045;oro-3,5-dibromobenzene;3-DibroMo-5-chlorobenzene;1,3-bromo-5-chlorobenzene;Phloroglucinol Impurity 57;1,3-DIBROMO-5-CHLOROBENZENE;3,5-Dibromo-1-chlorobenzene;Benzene, 1,3-dibromo-5-chloro-
- CBNumber
- CB4127709
- Molecular Formula
- C6H3Br2Cl
- Formula Weight
- 270.35
- MOL File
- 14862-52-3.mol
1,3-Dibromo-5-chlorobenzene Property
- Melting point:
- 91-94 °C (lit.)
- Boiling point:
- 256 °C
- Density
- 2.021±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- soluble in Toluene
- form
- powder to crystal
- color
- White to Light yellow
- InChI
- InChI=1S/C6H3Br2Cl/c7-4-1-5(8)3-6(9)2-4/h1-3H
- InChIKey
- FNKCOUREFBNNHG-UHFFFAOYSA-N
- SMILES
- C1(Br)=CC(Cl)=CC(Br)=C1
- CAS DataBase Reference
- 14862-52-3(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38
- Safety Statements
- 26-36-37/39
- WGK Germany
- 3
- HS Code
- 29039990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 129127
- Product name
- 1-Chloro-3,5-dibromobenzene
- Purity
- 95%
- Packaging
- 5g
- Price
- $32.6
- Updated
- 2023/06/20
- Product number
- D3465
- Product name
- 1,3-Dibromo-5-chlorobenzene
- Packaging
- 5G
- Price
- $31
- Updated
- 2025/07/31
- Product number
- D3465
- Product name
- 1,3-Dibromo-5-chlorobenzene
- Packaging
- 25G
- Price
- $97
- Updated
- 2025/07/31
- Product number
- D425225
- Product name
- 1,3-Dibromo-5-chlorobenzene
- Packaging
- 5G
- Price
- $60
- Updated
- 2021/12/16
- Product number
- D425225
- Product name
- 1,3-Dibromo-5-chlorobenzene
- Packaging
- 1g
- Price
- $50
- Updated
- 2021/12/16
1,3-Dibromo-5-chlorobenzene Chemical Properties,Usage,Production
Chemical Properties
white to light yellow crystal powder
Uses
1,3-Dibromo-5-chlorobenzene is a reactant in the preparation of orally bioavailable 1-(1H-indol-4-yl)-3,5-disubstituted benzene analogs as antimitotic agents.
Synthesis
626-39-1
14862-52-3
General procedure for the synthesis of 1,3-dibromo-5-chlorobenzene from 1,3,5-tribromobenzene: 1,3,5-tribromobenzene (9.44 g, 30 mmol) was dissolved in 120 mL of ethyl ether and cooled to -78 °C in a dry ice/acetone bath. Over 10 min, n-butyllithium (13.2 mL of a 2.5 M hexane solution, 33 mmol) was added slowly and dropwise. The reaction mixture was continued to be stirred at -78 °C for 10 min, followed by the addition of hexachloroethane (7.15 g, 30.2 mmol) in batches over 3 min. After addition, the reaction mixture was stirred at -78 °C for 15 minutes, then brought to room temperature and stirred for 3.2 hours. Upon completion of the reaction, the mixture was transferred to a dispensing funnel and partitioned by adding 100 mL of water and 100 mL of ethyl acetate. The aqueous layer was separated and extracted with another 100 mL of ethyl acetate. The organic layers were combined, dried with anhydrous magnesium sulfate, filtered and concentrated under reduced pressure to give the light brown solid product 1,3-dibromo-5-chlorobenzene (7.72 g, 95% yield). The product was characterized by 1H NMR (CDCl3, 300 MHz): δ 7.57 (t, 1H), 7.47 (d, 2H).
References
[1] Patent: EP1208091, 2006, B1. Location in patent: Page/Page column 23
[2] Journal of Medicinal Chemistry, 2006, vol. 49, # 2, p. 727 - 739
[3] Tetrahedron Letters, 1997, vol. 38, # 9, p. 1559 - 1562
1,3-Dibromo-5-chlorobenzene Preparation Products And Raw materials
Raw materials
Preparation Products
1,3-Dibromo-5-chlorobenzene Suppliers
- Tel
- --
- Fax
- --
- Country
- France
- ProdList
- 49
- Advantage
- 58
- Tel
- --
- Fax
- --
- mark.witterholt@minakem.com
- Country
- France
- ProdList
- 200
- Advantage
- 30
View Lastest Price from 1,3-Dibromo-5-chlorobenzene manufacturers
- Product
- 1,3-Dibromo-5-chlorobenzene 14862-52-3
- Price
- US $10.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 5tons
- Release date
- 2024-12-03
- Product
- 3,5-Dibromochlorobenzene 14862-52-3
- Price
- US $150.00/KG
- Min. Order
- 1KG
- Purity
- 98%+
- Supply Ability
- 300MT/year
- Release date
- 2019-12-24
- Product
- 1,3-Dibromo-5-chlorobenzene 14862-52-3
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-10-08