Maropitant citrate hydrate
- Product Name
- Maropitant citrate hydrate
- CAS No.
- 359875-09-5
- Chemical Name
- Maropitant citrate hydrate
- Synonyms
- 2-HYDROXYPROPANE-1,2,3-TRICARBOXYLIC ACID;ethyl[(1R)-1-[(2R)-oxolan-2-yl]-2-phenylethyl]amine;4-(4-fluorophenyl)-1-[4-(1,2,4-triazol-1-yl)butyl]-3,6-dihydro-2H-pyridine;(7S,8S)-7-benzhydryl-N-[(2-methoxy-5-tert-butyl-phenyl)methyl]-1-azabicyclo[2.2.2]octan-8-amine;ACIDUM CITRICUM ANHYDRICUM;Maropitant citrate hydrate;(2S,3S)-N-(5-tert-butyl-2-methoxybenzyl)-2-(diphenylmethyl)-...;(2S,3S)-2-benzhydryl-N-[(5-tert-butyl-2-methoxyphenyl)methyl]-1-azabicyclo[2.2.2]octan-3-amine,2-hydroxypropane-1,2,3-tricarboxylic acid,hydrate;FEMA 2306;CT SUPPLEMENT
- CBNumber
- CB4127749
- Molecular Formula
- C38H48N2O8
- Formula Weight
- 660.81
- MOL File
- 359875-09-5.mol
Maropitant citrate hydrate Property
- Melting point:
- 153-159 °C(lit.)
- Flash point:
- 100 °C
- storage temp.
- 2-8°C
- solubility
- H2O: 1 M at 20 °C, clear, colorless
- form
- white to off-white crystalline powder
- Water Solubility
- Water: 3 mg/mL (4.42 mM)
- InChI
- InChI=1/C32H40N2O.C6H8O7/c1-32(2,3)27-15-16-28(35-4)26(21-27)22-33-30-25-17-19-34(20-18-25)31(30)29(23-11-7-5-8-12-23)24-13-9-6-10-14-24;7-3(8)1-6(13,5(11)12)2-4(9)10/h5-16,21,25,29-31,33H,17-20,22H2,1-4H3;13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)/t30-,31-;/s3
- InChIKey
- XDZPFSKCXRGRIO-OHTRWSNQNA-N
- SMILES
- C(O)(C(=O)O)(CC(=O)O)CC(=O)O.C(C1C=CC=CC=1)(C1C=CC=CC=1)[C@@H]1N2CCC(CC2)[C@@H]1NCC1C=C(C(C)(C)C)C=CC=1OC |&1:26,33,r|
- CAS DataBase Reference
- 359875-09-5(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi,T
- Risk Statements
- 41-42/43-36/37/38-25
- Safety Statements
- 26-39-45-36/37-22
- RIDADR
- UN 3284 6.1/PG 3
- WGK Germany
- 1
- RTECS
- GE7350000
- F
- 9
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H318Causes serious eye damage
H373May cause damage to organs through prolonged or repeated exposure
H400Very toxic to aquatic life
H410Very toxic to aquatic life with long lasting effects
- Precautionary statements
-
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P273Avoid release to the environment.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P310Immediately call a POISON CENTER or doctor/physician.
P314Get medical advice/attention if you feel unwell.
P391Collect spillage. Hazardous to the aquatic environment
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 77981
- Product name
- CT Supplement
- Purity
- for microbiology
- Packaging
- 5amp
- Price
- $145
- Updated
- 2024/03/01
- Product number
- CHM0992497
- Product name
- CT SUPPLEMENT
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $502.05
- Updated
- 2021/12/16
Maropitant citrate hydrate Chemical Properties,Usage,Production
Description
Maropitant citrate hydrate is a specific neurokinin-1 (NK-1) receptor antagonist that selectively inhibits the production of substance P, a mediator involved in signalling vomiting. Maropitant citrate was therefore originally used to treat vomiting in dogs and cats. Currently, it is also used as an adjunct to visceral analgesia in dogs and cats, and in other species such as horses and birds.
Uses
Anti-emetic.
Pharmacokinetics
The maximum, minimum, and average concentrations of maropitant achieved at steady state were 375.5 ± 200, 16.8 ± 7.7, and 73.5 ± 45.1 ng/ml, respectively. The terminal elimination half-life was 11.6 ± 1.4 hr, and the accumulation index was 1.3 ± 0.07. Heart rate decreased between Day 1 and Day 5 (p = .005), with three horses having heart rates of 20 beats per minute and atrioventricular block on Day 5. Pharmacokinetics of repeated maropitant administration suggests the drug could be considered for use in healthy horses.
Veterinary Drugs and Treatments
Maropitant citrate injectable solution is indicated for the prevention and treatment of acute vomiting in dogs; maropitant citrate tablets are indicated for the prevention of acute vomiting and the prevention of vomiting due to motion sickness in dogs. Both are also used extra-label in cats.
Maropitant citrate hydrate Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Maropitant citrate hydrate manufacturers
- Product
- Maropitant citrate hydrate 359875-09-5
- Price
- US $8.00-0.80/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2024-04-08
- Product
- Maropitant Citrate 359875-09-5
- Price
- US $110.00-90.00/kilogram
- Min. Order
- 1kilogram
- Purity
- 99%
- Supply Ability
- 10 tons/per week
- Release date
- 2023-12-12
- Product
- Maropitant Citrate Monohydrate 359875-09-5
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 100 tons
- Release date
- 2023-03-21