ChemicalBook > CAS DataBase List > Maropitant citrate hydrate

Maropitant citrate hydrate

Product Name
Maropitant citrate hydrate
CAS No.
359875-09-5
Chemical Name
Maropitant citrate hydrate
Synonyms
2-HYDROXYPROPANE-1,2,3-TRICARBOXYLIC ACID;ethyl[(1R)-1-[(2R)-oxolan-2-yl]-2-phenylethyl]amine;4-(4-fluorophenyl)-1-[4-(1,2,4-triazol-1-yl)butyl]-3,6-dihydro-2H-pyridine;(7S,8S)-7-benzhydryl-N-[(2-methoxy-5-tert-butyl-phenyl)methyl]-1-azabicyclo[2.2.2]octan-8-amine;ACIDUM CITRICUM ANHYDRICUM;Maropitant citrate hydrate;(2S,3S)-N-(5-tert-butyl-2-methoxybenzyl)-2-(diphenylmethyl)-...;(2S,3S)-2-benzhydryl-N-[(5-tert-butyl-2-methoxyphenyl)methyl]-1-azabicyclo[2.2.2]octan-3-amine,2-hydroxypropane-1,2,3-tricarboxylic acid,hydrate;FEMA 2306;CT SUPPLEMENT
CBNumber
CB4127749
Molecular Formula
C38H48N2O8
Formula Weight
660.81
MOL File
359875-09-5.mol
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Maropitant citrate hydrate Property

Melting point:
153-159 °C(lit.)
Flash point:
100 °C
storage temp. 
2-8°C
solubility 
H2O: 1 M at 20 °C, clear, colorless
form 
white to off-white crystalline powder
Water Solubility 
Water: 3 mg/mL (4.42 mM)
InChI
InChI=1/C32H40N2O.C6H8O7/c1-32(2,3)27-15-16-28(35-4)26(21-27)22-33-30-25-17-19-34(20-18-25)31(30)29(23-11-7-5-8-12-23)24-13-9-6-10-14-24;7-3(8)1-6(13,5(11)12)2-4(9)10/h5-16,21,25,29-31,33H,17-20,22H2,1-4H3;13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)/t30-,31-;/s3
InChIKey
XDZPFSKCXRGRIO-OHTRWSNQNA-N
SMILES
C(O)(C(=O)O)(CC(=O)O)CC(=O)O.C(C1C=CC=CC=1)(C1C=CC=CC=1)[C@@H]1N2CCC(CC2)[C@@H]1NCC1C=C(C(C)(C)C)C=CC=1OC |&1:26,33,r|
CAS DataBase Reference
359875-09-5(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi,T
Risk Statements 
41-42/43-36/37/38-25
Safety Statements 
26-39-45-36/37-22
RIDADR 
UN 3284 6.1/PG 3
WGK Germany 
1
RTECS 
GE7350000
F 
9
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H318Causes serious eye damage

H373May cause damage to organs through prolonged or repeated exposure

H400Very toxic to aquatic life

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P310Immediately call a POISON CENTER or doctor/physician.

P314Get medical advice/attention if you feel unwell.

P391Collect spillage. Hazardous to the aquatic environment

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
77981
Product name
CT Supplement
Purity
for microbiology
Packaging
5amp
Price
$145
Updated
2024/03/01
American Custom Chemicals Corporation
Product number
CHM0992497
Product name
CT SUPPLEMENT
Purity
95.00%
Packaging
5MG
Price
$502.05
Updated
2021/12/16
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Maropitant citrate hydrate Chemical Properties,Usage,Production

Description

Maropitant citrate hydrate is a specific neurokinin-1 (NK-1) receptor antagonist that selectively inhibits the production of substance P, a mediator involved in signalling vomiting. Maropitant citrate was therefore originally used to treat vomiting in dogs and cats. Currently, it is also used as an adjunct to visceral analgesia in dogs and cats, and in other species such as horses and birds.

Uses

Anti-emetic.

Pharmacokinetics

The maximum, minimum, and average concentrations of maropitant achieved at steady state were 375.5 ± 200, 16.8 ± 7.7, and 73.5 ± 45.1 ng/ml, respectively. The terminal elimination half-life was 11.6 ± 1.4 hr, and the accumulation index was 1.3 ± 0.07. Heart rate decreased between Day 1 and Day 5 (p = .005), with three horses having heart rates of 20 beats per minute and atrioventricular block on Day 5. Pharmacokinetics of repeated maropitant administration suggests the drug could be considered for use in healthy horses.

Veterinary Drugs and Treatments

Maropitant citrate injectable solution is indicated for the prevention and treatment of acute vomiting in dogs; maropitant citrate tablets are indicated for the prevention of acute vomiting and the prevention of vomiting due to motion sickness in dogs. Both are also used extra-label in cats.

Maropitant citrate hydrate Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Maropitant citrate hydrate manufacturers

HangZhou RunYan Pharma Technology Co.,LTD.
Product
Maropitant Citrate 359875-09-5
Price
US $0.00-0.00/MG
Min. Order
10MG
Purity
99% HPLC
Supply Ability
10000
Release date
2024-09-20
Hebei Yanxi Chemical Co., Ltd.
Product
Maropitant Citrate 359875-09-5
Price
US $20.00-1.00/kg
Min. Order
1kg
Purity
0.99
Supply Ability
10 tons
Release date
2023-11-23
Henan Fengda Chemical Co., Ltd
Product
Maropitant citrate hydrate 359875-09-5
Price
US $8.00-0.80/kg
Min. Order
1kg
Purity
99%
Supply Ability
g-kg-tons, free sample is available
Release date
2024-04-08

359875-09-5, Maropitant citrate hydrateRelated Search:

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