Ethyl 2,4-dihydroxy-6-methyl-3-pyridinecarboxylate
- Product Name
- Ethyl 2,4-dihydroxy-6-methyl-3-pyridinecarboxylate
- CAS No.
- 70254-52-3
- Chemical Name
- Ethyl 2,4-dihydroxy-6-methyl-3-pyridinecarboxylate
- Synonyms
- BUTTPARK 153\57-17;Ethyl2,4-dihydroxy-;Quinidine Impurity 19;Ethy 2,4-Dihydroxy-6-Methylnicotinate;ETHYL 2,4-DIHYDROXY-6-METHYLNICOTINATE;Ethyl2,4-Dihydroxy-6-methylnicotinate>Ethyl 2,4-dihydroxy-6-methylnicotinate 97%;ETHYL 2,4-DIHYDROXY-6-METHYL-3-PYRIDINECARBONATE;Ethyl 2,4-dihydrOxy-6-methy3-pyridinecarBOxylate;2,4-dihydroxy-6-Methyl-nicotinic acid ethyl ester
- CBNumber
- CB4128832
- Molecular Formula
- C9H11NO4
- Formula Weight
- 197.19
- MOL File
- 70254-52-3.mol
Ethyl 2,4-dihydroxy-6-methyl-3-pyridinecarboxylate Property
- Melting point:
- 205 °C
- Boiling point:
- 446.0±40.0 °C(Predicted)
- Density
- 1.312±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- soluble in Methanol
- form
- powder to crystal
- pka
- 8.08±0.28(Predicted)
- color
- White to Almost white
- InChI
- InChI=1S/C9H11NO4/c1-3-14-9(13)7-6(11)4-5(2)10-8(7)12/h4H,3H2,1-2H3,(H2,10,11,12)
- InChIKey
- CMCZAWPDHHYFPU-UHFFFAOYSA-N
- SMILES
- C1(O)=NC(C)=CC(O)=C1C(OCC)=O
- CAS DataBase Reference
- 70254-52-3(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- E0869
- Product name
- Ethyl 2,4-Dihydroxy-6-methylnicotinate
- Purity
- >98.0%(GC)(T)
- Packaging
- 1g
- Price
- $162
- Updated
- 2025/07/31
- Product number
- E0869
- Product name
- Ethyl 2,4-Dihydroxy-6-methylnicotinate
- Purity
- >98.0%(GC)(T)
- Packaging
- 5g
- Price
- $594
- Updated
- 2025/07/31
- Product number
- E917388
- Product name
- Ethyl 2,4-Dihydroxy-6-methylnicotinate
- Packaging
- 100mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- 448975
- Product name
- Ethyl 2,4-dihydroxy-6-methylnicotinate
- Packaging
- 100mg
- Price
- $305
- Updated
- 2021/12/16
- Product number
- OR5584
- Product name
- Ethyl 2,4-Dihydroxy-6-methylnicotinate
- Purity
- 97%
- Packaging
- 1g
- Price
- $15
- Updated
- 2021/12/16
Ethyl 2,4-dihydroxy-6-methyl-3-pyridinecarboxylate Chemical Properties,Usage,Production
Uses
Ethyl 2,4-Dihydroxy-6-methylnicotinate, is a building block used for various chemical compounds. It is used for the synthesis of analogs of Lucanthone, having antitumor and bactericidal properties.
Synthesis
626-34-6
105-53-3
10350-10-4
The general procedure for the synthesis of ethyl 4-hydroxy-6-methyl-2-oxo-1,2-dihydropyridine-3-carboxylate from ethyl 3-aminocrotonate and diethyl malonate was as follows: ethyl 3-aminocrotonate (100 g, 0.7752 mol) was added to a reactor, followed by the addition of sodium ethoxide (65 g, 0.9559 mol) and anhydrous ethanol (240 g). The reaction system was slowly heated to 80-90 °C, kept at reflux, and the reaction was stirred at this temperature for 24 hours. Upon completion of the reaction, the system was cooled to 50-60 °C and concentrated under reduced pressure to remove about 100 g of ethanol. The concentrated solution was slowly poured into 1000 ml of water, 10 g of basic activated carbon was added, stirred for 1 hour and filtered. The filtrate was cooled to below 0°C and the pH was adjusted to 2 to 3 with ammonium chloride, at which time a large amount of solid precipitated, and the solid was collected by filtration. The resulting solid was dried at 50 to 60°C to give white needle-like crystals of ethyl 2,4-dihydroxy-6-methyl-nicotinate in a yield of 125 g (yield = 81.85%, HPLC purity = 99.5%).
References
[1] Patent: CN106279011, 2017, A. Location in patent: Paragraph 0021; 0022
[2] Chemische Berichte, 1898, vol. 31, p. 766,769
[3] Chemische Berichte, 1898, vol. 31, p. 765
Ethyl 2,4-dihydroxy-6-methyl-3-pyridinecarboxylate Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Ethyl 2,4-dihydroxy-6-methyl-3-pyridinecarboxylate manufacturers
- Product
- Ethyl 2,4-dihydroxy-6-methyl-3-pyridinecarboxylate 70254-52-3
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-10-14
- Product
- Ethyl 2,4-dihydroxy-6-methyl-3-pyridinecarboxylate 70254-52-3
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 4t/month
- Release date
- 2023-07-21
- Product
- Ethyl 2,4-dihydroxy-6-methyl-3-pyridinecarboxylate 70254-52-3
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons Min
- Release date
- 2021-10-26