ChemicalBook > CAS DataBase List > 2-Iodophenol

2-Iodophenol

Product Name
2-Iodophenol
CAS No.
533-58-4
Chemical Name
2-Iodophenol
Synonyms
O-IODOPHENOL;ORTHO-IODOPHENOL;DK807;NSC 9245;o-Jodfenol;2-Jodfenol;2-iodo-pheno;2-IODOPHENOL;o-iodo-pheno;2-lodophenol
CBNumber
CB4130718
Molecular Formula
C6H5IO
Formula Weight
220.01
MOL File
533-58-4.mol
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2-Iodophenol Property

Melting point:
37-40 °C (lit.)
Boiling point:
186-187 °C/160 mmHg (lit.)
Density 
1.947 g/mL at 25 °C (lit.)
Flash point:
>230 °F
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
solubility 
Chloroform (Slightly), Ethyl Acetate (Slightly)
form 
Crystalline Powder or Crystalline Low Melting Mass
pka
8.51(at 25℃)
color 
White or cream to brown
Specific Gravity
1.947
Water Solubility 
slightly soluble
Sensitive 
Light Sensitive
Merck 
14,5035
BRN 
1855300
Stability:
Stable. Incompatible with strong oxidizing agents.
InChIKey
KQDJTBPASNJQFQ-UHFFFAOYSA-N
CAS DataBase Reference
533-58-4(CAS DataBase Reference)
NIST Chemistry Reference
Phenol, 2-iodo-(533-58-4)
EPA Substance Registry System
Phenol, 2-iodo- (533-58-4)
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Safety

Hazard Codes 
Xn,Xi
Risk Statements 
20/21/22-36/37/38
Safety Statements 
26-36-37/39
WGK Germany 
3
RTECS 
SL5500000
TSCA 
T
HazardClass 
IRRITANT, LIGHT SENSITIVE
HS Code 
29081000
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
281409
Product name
2-Iodophenol
Purity
98%
Packaging
5g
Price
$60.4
Updated
2024/03/01
Sigma-Aldrich
Product number
281409
Product name
2-Iodophenol
Purity
98%
Packaging
25g
Price
$121
Updated
2024/03/01
TCI Chemical
Product number
I0460
Product name
2-Iodophenol
Purity
>99.0%(GC)
Packaging
5g
Price
$41
Updated
2024/03/01
TCI Chemical
Product number
I0460
Product name
2-Iodophenol
Purity
>99.0%(GC)
Packaging
25g
Price
$134
Updated
2024/03/01
Alfa Aesar
Product number
A13599
Product name
2-Iodophenol, 98%
Packaging
5g
Price
$34.65
Updated
2024/03/01
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2-Iodophenol Chemical Properties,Usage,Production

Chemical Properties

colorless needle-like crystals or Pale Yellow Low Melting Solid. Slightly soluble in water, easily soluble in organic solvents such as ethanol and ether.

Uses

2-Iodophenol is used in the synthesis of aryl 2-benzofuranyl and aryl 2-indolyl carbinols of high enantiomeric purity and 3,3-disubstituted-2,3-dihydrobenzofurans. Coupling with phenylacetylene in the presence of a Pd complex and CuI gives 2-phenylbenzofuran in good yield.

Application

2-Iodophenol is a halophenol with antifungal activity. 2-Iodophenol was used in the synthesis of:
aryl 2-benzofuranyl and aryl 2-indolyl carbinols of high enantiomeric purity
3,3-disubstituted-2,3-dihydrobenzofurans
1,3,5-substituted benzenes.
2-Iodophenol is also used as additive tracers for resist plasm a etching and suzuki reaction.

Preparation

synthesis of 2-iodophenol: phenol (1a) to react with 0.5 equivalent of iodine and 1 equivalent of hydrogen peroxide in water at room temperature for 24 h, 2,6-diiodophenol (2a) and 2-iodophenol (3) were isolated in yields of 21 and 49%, respectively.

Definition

ChEBI: 2-iodophenol is a 2-halophenol and an iodophenol.

Synthesis Reference(s)

The Journal of Organic Chemistry, 53, p. 5281, 1988 DOI: 10.1021/jo00257a014

General Description

Rapid palladium-catalyzed carbonylative cyclization reactions of 2-iodophenol with various alkyne under microwave irradiation using Mo(CO)6 as the CO source has been investigated.

Purification Methods

Crystallise 2-iodophenol from CHCl3 or diethyl ether. The acetate has m 65-66o (from MeOH). [Beilstein 6 H 208, 6 II 198, 6 III 774, 6 IV 1074.]

2-Iodophenol Preparation Products And Raw materials

Raw materials

Preparation Products

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2-Iodophenol Suppliers

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View Lastest Price from 2-Iodophenol manufacturers

Hebei Weibang Biotechnology Co., Ltd
Product
2-Iodophenol 533-58-4
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20 mt
Release date
2023-04-27
Hebei Chuanghai Biotechnology Co,.LTD
Product
2-Iodophenol 533-58-4
Price
US $30.00-10.00/kg
Min. Order
10kg
Purity
99%
Supply Ability
100000kg
Release date
2024-08-14
Henan Fengda Chemical Co., Ltd
Product
2-Iodophenol 533-58-4
Price
US $100.00-1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
g-kg-tons, free sample is available
Release date
2023-12-24

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