V-9-M cholecystokinin nonapeptide

ChemicalBook > CAS DataBase List > V-9-M cholecystokinin nonapeptide

V-9-M cholecystokinin nonapeptide

Product Name: V-9-M cholecystokinin nonapeptide
CAS No.: 99291-20-0
Chemical Name: V-9-M cholecystokinin nonapeptide
Synonyms: Cholecystokinin Precursor (24-32) (rat) H-Val-Pro-Val-Glu-Ala-Val-Asp-Pro-Met-OH;Smeglutide;Semaglutide（Recombinant）;Cholecystokinin Precursor;V-9-M cholecystokinin nonapeptide;L-Valyl-L-prolyl-L-valyl-L-α-glutamyl-L-alanyl-L-valyl-L-α-aspartyl-L-prolyl-L-methionine;L-Methionine,L-valyl-L-prolyl-L-valyl-L-a-glutamyl-L-alanyl-L-valyl-L-a-aspartyl-L-prolyl-;L-Methionine, L-valyl-L-prolyl-L-valyl-L-α-glutamyl-L-alanyl-L-valyl-L-α-aspartyl-L-prolyl-;V 9 M|||Prepro CCK Fragment V-9-M|||Val-pro-val-glu-ala-val-asp-pro-met|||Cholecystokinin Precursor (24-32)|||V9M|||V-9-M;(4S)-4-[[(2S)-2-[[(2S)-1-[(2S)-2-amino-3-methylbutanoyl]pyrrolidine-2-carbonyl]amino]-3-methylbutanoyl]amino]-5-[[(2S)-1-[[(2S)-1-[[(2S)-3-carboxy-1-[(2S)-2-[[(1S)-1-carboxy-3-methylsulfanylpropyl]carbamoyl]pyrrolidin-1-yl]-1-oxopropan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-1-oxopropan-2-yl]amino]-5-oxopentanoic acid
CBNumber: CB41331642
Molecular Formula: C42H69N9O14S
Formula Weight: 956.11
MOL File: 99291-20-0.mol

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V-9-M cholecystokinin nonapeptide Property

Boiling point:: 1350.7±65.0 °C(Predicted)
Density: 1.306±0.06 g/cm3(Predicted)
pka: 3.51±0.10(Predicted)
form: Solid
color: White to off-white
InChIKey: AIKMAJWJXJPJNB-HNRKYVDVNA-N

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Biosynth Carbosynth

Product number: FC110391
Product name: Cholecystokinin Precursor (24-32) (rat) H-Val-Pro-Val-Glu-Ala-Val-Asp-Pro-Met-OH
Packaging: 2mg
Price: $205
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC110391
Product name: Cholecystokinin Precursor (24-32) (rat) H-Val-Pro-Val-Glu-Ala-Val-Asp-Pro-Met-OH
Packaging: 10mg
Price: $697
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC110391
Product name: Cholecystokinin Precursor (24-32) (rat) H-Val-Pro-Val-Glu-Ala-Val-Asp-Pro-Met-OH
Packaging: 25mg
Price: $1515.25
Updated: 2021/12/16

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V-9-M cholecystokinin nonapeptide Chemical Properties,Usage,Production

Description

V-9-M Cholecystokinin nonapeptide is a glucagon-like peptide receptor agonist, namely GLP-1 receptor agonist. Human GLP-1 is a peptide hormone secreted by intestinal L cells. Cholecystokinin Precursor (24-32), rat has apparent sedative actions and prevents experimental amnesisa in rats.

Uses

V-9-M cholecystokinin nonapeptide belongs to the glucagon-like peptide-1 receptor agonist (GLP-1 receptor agonist) class of hypoglycemic drugs, which increase insulin secretion in a glucose-dependent manner and inhibit glucagon secretion , and can promote gastric emptying, centrally suppress appetite, reduce food intake, and then reduce glucose absorption to achieve the effect of lowering blood sugar.

General Description

V-9-M cholecystokinin nonapeptide, also known as Cholecystokinin Precursor (24-32) (rat), is a precursor compound of cholecystokinin (CCK) that is expressed in the heart, lungs, and kidneys as well as in the gastrointestinal tract and brain. Cholecystokinin (CCK) is a brain-gut peptide that stimulates gallbladder contraction and pancreatic exocrine secretion, as well as a neurotransmitter. It can be extracted from the small intestine of dogs and cats and causes gallbladder contractions.

Mechanism of action

V-9-M cholecystokinin nonapeptide's mechanism of action is to act on islet beta cells, promote the synthesis and secretion of insulin, stimulate the proliferation and differentiation of islet beta cells, inhibit the apoptosis of islet beta cells, increase the number of islet beta cells, and protect islet function. It can also act on islet alpha cells, inhibit the release of glucagon, and reduce the release of hepatic glucose.

Solubility in organics

V-9-M cholecystokinin nonapeptide is soluble in DMSO solution, the reference solubility range is shown below:

storage

Store at low temperatures to avoid moisture:
Powder: -20°C, 3 years.
Solvents: -80°C, 2 years.

References

1. Takashima A, Itoh S. Neuropharmacological properties of V-9-M, a putative neuropeptide derived from procholecystokinin, in the rat. Can J Physiol Pharmacol. 1989 Mar;67(3):223-7. DOI: 10.1016/0301-0082(90)90035-F
2. Cholecytokinin (CCK) gene-related peptides: distribution and characterization of immunoreactive pro-CCK and an amino-terminal pro-CCK fragment in rat brain. DOI: 10.1016/0006-8993(85)90813-3
3. Cao G, Beinfeld MC. Calcium-dependent pro-cholecystokinin V-9-M immunoreactive peptide release from rat brain slices and CCK-secreting rat medullary thyroid carcinoma cells in culture. Peptides. 1992 Nov-Dec;13(6):1087-90. DOI: 10.1016/0196-9781(92)90011-Q

V-9-M cholecystokinin nonapeptide Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from V-9-M cholecystokinin nonapeptide manufacturers

Dorne Chemical Technology co. LTD

Product: V-9-M cholecystokinin nonapeptide 99291-20-0
Price: US $1.00/g
Min. Order: 1g
Purity: 99%
Supply Ability: 100kg
Release date: 2024-03-26

Hebei Mujin Biotechnology Co.,Ltd

Product: semaglutide 99291-20-0
Price: US $0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 50000KG/month
Release date: 2023-09-11

Hebei Mujin Biotechnology Co.,Ltd

Product: Semaglutide 99291-20-0
Price: US $0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 50000KG/month
Release date: 2023-09-11

99291-20-0, V-9-M cholecystokinin nonapeptideRelated Search:

H-GLY-TYR-PRO-GLY-LYS-PHE-OH NEUROPEPTIDE W-30 (RAT) Atrial Natriuretic Factor (3-28) (rat) ANGIOTENSINOGEN (1-14) (RAT) ATRIAL NATRIURETIC PEPTIDE (126-150) (RAT) BNP-32 (RAT) CORTISTATIN-14 GHRELIN (RAT) COAGULATION FACTOR II RECEPTOR-LIKE 2 (1-6) AMIDE (MOUSE) ATRIOPEPTIN I (RAT) Cholecystokinin

V-9-M cholecystokinin nonapeptide

Cholecystokinin Precursor (24-32) (rat) H-Val-Pro-Val-Glu-Ala-Val-Asp-Pro-Met-OH

(4S)-4-[[(2S)-2-[[(2S)-1-[(2S)-2-amino-3-methylbutanoyl]pyrrolidine-2-carbonyl]amino]-3-methylbutanoyl]amino]-5-[[(2S)-1-[[(2S)-1-[[(2S)-3-carboxy-1-[(2S)-2-[[(1S)-1-carboxy-3-methylsulfanylpropyl]carbamoyl]pyrrolidin-1-yl]-1-oxopropan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-1-oxopropan-2-yl]amino]-5-oxopentanoic acid

L-Methionine, L-valyl-L-prolyl-L-valyl-L-α-glutamyl-L-alanyl-L-valyl-L-α-aspartyl-L-prolyl-

L-Valyl-L-prolyl-L-valyl-L-α-glutamyl-L-alanyl-L-valyl-L-α-aspartyl-L-prolyl-L-methionine

Smeglutide

Cholecystokinin Precursor

L-Methionine,L-valyl-L-prolyl-L-valyl-L-a-glutamyl-L-alanyl-L-valyl-L-a-aspartyl-L-prolyl-

Semaglutide（Recombinant）

V 9 M|||Prepro CCK Fragment V-9-M|||Val-pro-val-glu-ala-val-asp-pro-met|||Cholecystokinin Precursor (24-32)|||V9M|||V-9-M

99291-20-0

91043-68-2

C42H69N9O14S

Peptide

99291-20-0

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