V-9-M cholecystokinin nonapeptide

Product Name: V-9-M cholecystokinin nonapeptide
CAS No.: 99291-20-0
Chemical Name: V-9-M cholecystokinin nonapeptide
Synonyms: Cholecystokinin Precursor (24-32) (rat) H-Val-Pro-Val-Glu-Ala-Val-Asp-Pro-Met-OH;Smeglutide;Semaglutide（Recombinant）;Cholecystokinin Precursor;V-9-M cholecystokinin nonapeptide;L-Valyl-L-prolyl-L-valyl-L-α-glutamyl-L-alanyl-L-valyl-L-α-aspartyl-L-prolyl-L-methionine;L-Methionine,L-valyl-L-prolyl-L-valyl-L-a-glutamyl-L-alanyl-L-valyl-L-a-aspartyl-L-prolyl-;L-Methionine, L-valyl-L-prolyl-L-valyl-L-α-glutamyl-L-alanyl-L-valyl-L-α-aspartyl-L-prolyl-;V 9 M|||Prepro CCK Fragment V-9-M|||Val-pro-val-glu-ala-val-asp-pro-met|||Cholecystokinin Precursor (24-32)|||V9M|||V-9-M;(4S)-4-[[(2S)-2-[[(2S)-1-[(2S)-2-amino-3-methylbutanoyl]pyrrolidine-2-carbonyl]amino]-3-methylbutanoyl]amino]-5-[[(2S)-1-[[(2S)-1-[[(2S)-3-carboxy-1-[(2S)-2-[[(1S)-1-carboxy-3-methylsulfanylpropyl]carbamoyl]pyrrolidin-1-yl]-1-oxopropan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-1-oxopropan-2-yl]amino]-5-oxopentanoic acid
CBNumber: CB41331642
Molecular Formula: C42H69N9O14S
Formula Weight: 956.11
MOL File: 99291-20-0.mol

More

Less

V-9-M cholecystokinin nonapeptide Property

Boiling point:: 1350.7±65.0 °C(Predicted)
Density: 1.306±0.06 g/cm3(Predicted)
pka: 3.51±0.10(Predicted)
form: Solid
color: White to off-white
InChIKey: AIKMAJWJXJPJNB-HNRKYVDVNA-N

More

Less

Hazard and Precautionary Statements (GHS)

More

Less

N-Bromosuccinimide Price

Biosynth Carbosynth

Product number: FC110391
Product name: Cholecystokinin Precursor (24-32) (rat) H-Val-Pro-Val-Glu-Ala-Val-Asp-Pro-Met-OH
Packaging: 2mg
Price: $205
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC110391
Product name: Cholecystokinin Precursor (24-32) (rat) H-Val-Pro-Val-Glu-Ala-Val-Asp-Pro-Met-OH
Packaging: 10mg
Price: $697
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC110391
Product name: Cholecystokinin Precursor (24-32) (rat) H-Val-Pro-Val-Glu-Ala-Val-Asp-Pro-Met-OH
Packaging: 25mg
Price: $1515.25
Updated: 2021/12/16

More

Less

V-9-M cholecystokinin nonapeptide Chemical Properties,Usage,Production

Description

V-9-M Cholecystokinin nonapeptide is a glucagon-like peptide receptor agonist, namely GLP-1 receptor agonist. Human GLP-1 is a peptide hormone secreted by intestinal L cells. Cholecystokinin Precursor (24-32), rat has apparent sedative actions and prevents experimental amnesisa in rats.

Uses

V-9-M cholecystokinin nonapeptide belongs to the glucagon-like peptide-1 receptor agonist (GLP-1 receptor agonist) class of hypoglycemic drugs, which increase insulin secretion in a glucose-dependent manner and inhibit glucagon secretion , and can promote gastric emptying, centrally suppress appetite, reduce food intake, and then reduce glucose absorption to achieve the effect of lowering blood sugar.

General Description

V-9-M cholecystokinin nonapeptide, also known as Cholecystokinin Precursor (24-32) (rat), is a precursor compound of cholecystokinin (CCK) that is expressed in the heart, lungs, and kidneys as well as in the gastrointestinal tract and brain. Cholecystokinin (CCK) is a brain-gut peptide that stimulates gallbladder contraction and pancreatic exocrine secretion, as well as a neurotransmitter. It can be extracted from the small intestine of dogs and cats and causes gallbladder contractions.

Mechanism of action

V-9-M cholecystokinin nonapeptide's mechanism of action is to act on islet beta cells, promote the synthesis and secretion of insulin, stimulate the proliferation and differentiation of islet beta cells, inhibit the apoptosis of islet beta cells, increase the number of islet beta cells, and protect islet function. It can also act on islet alpha cells, inhibit the release of glucagon, and reduce the release of hepatic glucose.

Solubility in organics

V-9-M cholecystokinin nonapeptide is soluble in DMSO solution, the reference solubility range is shown below:

storage

Store at low temperatures to avoid moisture:
Powder: -20°C, 3 years.
Solvents: -80°C, 2 years.

References

1. Takashima A, Itoh S. Neuropharmacological properties of V-9-M, a putative neuropeptide derived from procholecystokinin, in the rat. Can J Physiol Pharmacol. 1989 Mar;67(3):223-7. DOI: 10.1016/0301-0082(90)90035-F
2. Cholecytokinin (CCK) gene-related peptides: distribution and characterization of immunoreactive pro-CCK and an amino-terminal pro-CCK fragment in rat brain. DOI: 10.1016/0006-8993(85)90813-3
3. Cao G, Beinfeld MC. Calcium-dependent pro-cholecystokinin V-9-M immunoreactive peptide release from rat brain slices and CCK-secreting rat medullary thyroid carcinoma cells in culture. Peptides. 1992 Nov-Dec;13(6):1087-90. DOI: 10.1016/0196-9781(92)90011-Q

V-9-M cholecystokinin nonapeptide Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

V-9-M cholecystokinin nonapeptide Suppliers

China 106 United Kingdom 1 United States 1 Global 108

Zhangzhou Sinobioway Peptide Co. Ltd.

Tel: 18750546777
Email: 18750546777@163.COM
Country: China
ProdList: 6069
Advantage: 58

Chinese Peptide Company

Tel: 0571-86737118-8680 15988144796
Email: sales@chinesepeptide.com
Country: China
ProdList: 12
Advantage: 58

HANGZHOU KELAI BIOMEDICAL TECHNOLOGY Co., Ltd.

Tel: 18957050573
Email: 752803249@qq.com
Country: China
ProdList: 245
Advantage: 58

BJV(SHENZHEN) BIOTECH LTD

Tel: 19006605307
Email: 1026972457@qq.com
Country: China
ProdList: 77
Advantage: 58

Hubei Chuyunshun Biotechnology Co., Ltd

Tel: 15926415536 15926415536
Email: hbcyssw@163.com
Country: China
ProdList: 32
Advantage: 58

Zhejiang Zerui Biomedicine Co. , Ltd.

Tel: 18967171527
Email: 2187735310@qq.com
Country: China
ProdList: 7
Advantage: 58

Chemsky (shanghai) International Co.,Ltd

Tel: 021-50135380
Email: shchemsky@sina.com
Country: China
ProdList: 15402
Advantage: 60

Jinan Chenghui Shuangda biological Co., LTD

Tel: 0531-58897003 15550412551
Fax: 0531-58897003
Email: market@jnchsd.com
Country: China
ProdList: 211
Advantage: 62

Nanjing Sunlida Biological Technology Co., Ltd.

Tel: 025-57798810
Fax: 025-57019371
Email: sales@sunlidabio.com
Country: China
ProdList: 3239
Advantage: 55

Conier Chem & Pharma Co.,Ltd,

Tel: 023-62879767 13996269627;
Fax: +86-28-84559521
Email: sales@conier.com
Country: China
ProdList: 294
Advantage: 56

More

Less

View Lastest Price from V-9-M cholecystokinin nonapeptide manufacturers

Dorne Chemical Technology co. LTD

Product: V-9-M cholecystokinin nonapeptide 99291-20-0
Price: US $1.00/g
Min. Order: 1g
Purity: 99%
Supply Ability: 100kg
Release date: 2024-03-26

Strong peptide cross-border e-commerce Co. LTD

Product: V-9-M cholecystokinin nonapeptide 99291-20-0
Price: US $80.00-70.00/box
Min. Order: 1box
Purity: 99.9+
Supply Ability: 2000box
Release date: 2024-05-23

Wuhan Haorong Biotechnology Co.,Ltd

Product: V-9-M cholecystokinin nonapeptide 99291-20-0
Price: US $0.00-0.00/kg
Min. Order: 20kg
Purity: 99%
Supply Ability: 200000
Release date: 2023-08-21

99291-20-0, V-9-M cholecystokinin nonapeptideRelated Search:

H-GLY-TYR-PRO-GLY-LYS-PHE-OH NEUROPEPTIDE W-30 (RAT) Atrial Natriuretic Factor (3-28) (rat) ANGIOTENSINOGEN (1-14) (RAT) ATRIAL NATRIURETIC PEPTIDE (126-150) (RAT) BNP-32 (RAT) CORTISTATIN-14 GHRELIN (RAT) COAGULATION FACTOR II RECEPTOR-LIKE 2 (1-6) AMIDE (MOUSE) ATRIOPEPTIN I (RAT) Cholecystokinin

V-9-M cholecystokinin nonapeptide

Cholecystokinin Precursor (24-32) (rat) H-Val-Pro-Val-Glu-Ala-Val-Asp-Pro-Met-OH

(4S)-4-[[(2S)-2-[[(2S)-1-[(2S)-2-amino-3-methylbutanoyl]pyrrolidine-2-carbonyl]amino]-3-methylbutanoyl]amino]-5-[[(2S)-1-[[(2S)-1-[[(2S)-3-carboxy-1-[(2S)-2-[[(1S)-1-carboxy-3-methylsulfanylpropyl]carbamoyl]pyrrolidin-1-yl]-1-oxopropan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-1-oxopropan-2-yl]amino]-5-oxopentanoic acid

L-Methionine, L-valyl-L-prolyl-L-valyl-L-α-glutamyl-L-alanyl-L-valyl-L-α-aspartyl-L-prolyl-

L-Valyl-L-prolyl-L-valyl-L-α-glutamyl-L-alanyl-L-valyl-L-α-aspartyl-L-prolyl-L-methionine

Smeglutide

Cholecystokinin Precursor

L-Methionine,L-valyl-L-prolyl-L-valyl-L-a-glutamyl-L-alanyl-L-valyl-L-a-aspartyl-L-prolyl-

Semaglutide（Recombinant）

V 9 M|||Prepro CCK Fragment V-9-M|||Val-pro-val-glu-ala-val-asp-pro-met|||Cholecystokinin Precursor (24-32)|||V9M|||V-9-M

99291-20-0

91043-68-2

C42H69N9O14S

Peptide

99291-20-0

API