geninthiocin

Product Name: geninthiocin
CAS No.: 158792-27-9
Chemical Name: geninthiocin
Synonyms: geninthiocin;Geninthiocin A;PubChem ID: 16129809;14-DeMethylberinaMycin;Alaninamide, L-threonyl-2-[(1Z)-1-amino-1-propen-1-yl]-4-oxazolecarbonyl-2,3-didehydroalanyl-3-methyl-L-threonyl-2-(1-aminoethenyl)-5-methyl-4-oxazolecarbonyl-2,3-didehydroalanyl-6-[2-(1-aminoethenyl)-4-oxazolyl]-5-(4-carboxy-2-thiazolyl)-2-pyridinecarbonyl-2,3-didehydroalanyl-2,3-didehydro-, (7→1)-...
CBNumber: CB41333237
Molecular Formula: C50H49N15O15S
Formula Weight: 1132.08
MOL File: 158792-27-9.mol

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geninthiocin Property

Density: 1.54±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMF: soluble; DMSO: soluble; Ethanol: slightly soluble
form: White to off-white amorphous powder.
pka: 10.01±0.60(Predicted)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 28125
Product name: Geninthiocin A
Packaging: 500μg
Price: $323
Updated: 2024/03/01

Cayman Chemical

Product number: 28125
Product name: Geninthiocin A
Packaging: 2.5mg
Price: $1127
Updated: 2024/03/01

Usbiological

Product number: G2024-66
Product name: Geninthiocin
Packaging: 500ug
Price: $523
Updated: 2021/12/16

TRC

Product number: G350058
Product name: Geninthiocin
Packaging: 500μg
Price: $295
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0019325
Product name: GENINTHIOCIN
Purity: 95.00%
Packaging: 0.5MG
Price: $549
Updated: 2021/12/16

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geninthiocin Chemical Properties,Usage,Production

Description

Geninthiocin A is a cyclic thiopeptide bacterial metabolite originally isolated from Streptomyces sp. DD84. It is active against a variety of Gram-positive bacteria (MICs = 0.2-4 μg/ml), the Gram-negative bacterium C. violaceum (MIC = 19 μg/ml), and the fungus M. hiemalis (MIC = 38 μg/ml). Geninthiocin A also induces tipA promoter transcription with a minimum induction concentration of 1.2 ng/ml.

Uses

Geninthiocin, a thiopeptide antibiotic isolated from a Streptomyces sp., is a potent activator of the tipA gene, a bacterial transcription regulator involved in multidrug resistance. Geninthiocin displays a 10-fold selectivity for bacteria over mammalian cells lines, whereas the related dedialanyl geninthiocin shows the reverse selectivity. Geninthiocin is closely related to siomycin, a recently discovered inhibitor of oncogenic transcription factor, FoxM1.

Uses

Geninthiocin is a thiopeptide antibiotic tipA gene activator.

geninthiocin Preparation Products And Raw materials

Raw materials

Preparation Products

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geninthiocin Suppliers

China 20 France 1 Germany 1 United Kingdom 1 United States 5 Global 28

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geninthiocin

14-DeMethylberinaMycin

PubChem ID: 16129809

Geninthiocin A

Alaninamide, L-threonyl-2-[(1Z)-1-amino-1-propen-1-yl]-4-oxazolecarbonyl-2,3-didehydroalanyl-3-methyl-L-threonyl-2-(1-aminoethenyl)-5-methyl-4-oxazolecarbonyl-2,3-didehydroalanyl-6-[2-(1-aminoethenyl)-4-oxazolyl]-5-(4-carboxy-2-thiazolyl)-2-pyridinecarbonyl-2,3-didehydroalanyl-2,3-didehydro-, (7→1)-...

158792-27-9

C50H49N15O15S