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geninthiocin

Product Name
geninthiocin
CAS No.
158792-27-9
Chemical Name
geninthiocin
Synonyms
geninthiocin;Geninthiocin A;PubChem ID: 16129809;14-DeMethylberinaMycin;Alaninamide, L-threonyl-2-[(1Z)-1-amino-1-propen-1-yl]-4-oxazolecarbonyl-2,3-didehydroalanyl-3-methyl-L-threonyl-2-(1-aminoethenyl)-5-methyl-4-oxazolecarbonyl-2,3-didehydroalanyl-6-[2-(1-aminoethenyl)-4-oxazolyl]-5-(4-carboxy-2-thiazolyl)-2-pyridinecarbonyl-2,3-didehydroalanyl-2,3-didehydro-, (7→1)-...
CBNumber
CB41333237
Molecular Formula
C50H49N15O15S
Formula Weight
1132.08
MOL File
158792-27-9.mol
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geninthiocin Property

Density 
1.54±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMF: soluble; DMSO: soluble; Ethanol: slightly soluble
form 
White to off-white amorphous powder.
pka
10.01±0.60(Predicted)
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
28125
Product name
Geninthiocin A
Packaging
500μg
Price
$323
Updated
2024/03/01
Cayman Chemical
Product number
28125
Product name
Geninthiocin A
Packaging
2.5mg
Price
$1127
Updated
2024/03/01
Usbiological
Product number
G2024-66
Product name
Geninthiocin
Packaging
500ug
Price
$523
Updated
2021/12/16
TRC
Product number
G350058
Product name
Geninthiocin
Packaging
500μg
Price
$295
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0019325
Product name
GENINTHIOCIN
Purity
95.00%
Packaging
0.5MG
Price
$549
Updated
2021/12/16
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geninthiocin Chemical Properties,Usage,Production

Description

Geninthiocin A is a cyclic thiopeptide bacterial metabolite originally isolated from Streptomyces sp. DD84. It is active against a variety of Gram-positive bacteria (MICs = 0.2-4 μg/ml), the Gram-negative bacterium C. violaceum (MIC = 19 μg/ml), and the fungus M. hiemalis (MIC = 38 μg/ml). Geninthiocin A also induces tipA promoter transcription with a minimum induction concentration of 1.2 ng/ml.

Uses

Geninthiocin, a thiopeptide antibiotic isolated from a Streptomyces sp., is a potent activator of the tipA gene, a bacterial transcription regulator involved in multidrug resistance. Geninthiocin displays a 10-fold selectivity for bacteria over mammalian cells lines, whereas the related dedialanyl geninthiocin shows the reverse selectivity. Geninthiocin is closely related to siomycin, a recently discovered inhibitor of oncogenic transcription factor, FoxM1.

Uses

Geninthiocin is a thiopeptide antibiotic tipA gene activator.

geninthiocin Preparation Products And Raw materials

Raw materials

Preparation Products

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geninthiocin Suppliers

Shanghai EFE Biological Technology Co., Ltd.
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China
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86-(0)29-85992781 17792393971
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sales@glpbio.cn
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+86-400-002-6226 +86-13028896684;
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ChemeGen(Shanghai) Biotechnology Co.,Ltd.
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QQ 3610331285
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400-820-6829
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158792-27-9, geninthiocinRelated Search:


  • geninthiocin
  • 14-DeMethylberinaMycin
  • PubChem ID: 16129809
  • Geninthiocin A
  • Alaninamide, L-threonyl-2-[(1Z)-1-amino-1-propen-1-yl]-4-oxazolecarbonyl-2,3-didehydroalanyl-3-methyl-L-threonyl-2-(1-aminoethenyl)-5-methyl-4-oxazolecarbonyl-2,3-didehydroalanyl-6-[2-(1-aminoethenyl)-4-oxazolyl]-5-(4-carboxy-2-thiazolyl)-2-pyridinecarbonyl-2,3-didehydroalanyl-2,3-didehydro-, (7→1)-...
  • 158792-27-9
  • C50H49N15O15S