geninthiocin
- Product Name
- geninthiocin
- CAS No.
- 158792-27-9
- Chemical Name
- geninthiocin
- Synonyms
- geninthiocin;Geninthiocin A;PubChem ID: 16129809;14-DeMethylberinaMycin;Alaninamide, L-threonyl-2-[(1Z)-1-amino-1-propen-1-yl]-4-oxazolecarbonyl-2,3-didehydroalanyl-3-methyl-L-threonyl-2-(1-aminoethenyl)-5-methyl-4-oxazolecarbonyl-2,3-didehydroalanyl-6-[2-(1-aminoethenyl)-4-oxazolyl]-5-(4-carboxy-2-thiazolyl)-2-pyridinecarbonyl-2,3-didehydroalanyl-2,3-didehydro-, (7→1)-...
- CBNumber
- CB41333237
- Molecular Formula
- C50H49N15O15S
- Formula Weight
- 1132.08
- MOL File
- 158792-27-9.mol
geninthiocin Property
- Density
- 1.54±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMF: soluble; DMSO: soluble; Ethanol: slightly soluble
- form
- White to off-white amorphous powder.
- pka
- 10.01±0.60(Predicted)
N-Bromosuccinimide Price
- Product number
- 28125
- Product name
- Geninthiocin A
- Packaging
- 500μg
- Price
- $323
- Updated
- 2024/03/01
- Product number
- 28125
- Product name
- Geninthiocin A
- Packaging
- 2.5mg
- Price
- $1127
- Updated
- 2024/03/01
- Product number
- G2024-66
- Product name
- Geninthiocin
- Packaging
- 500ug
- Price
- $523
- Updated
- 2021/12/16
- Product number
- G350058
- Product name
- Geninthiocin
- Packaging
- 500μg
- Price
- $295
- Updated
- 2021/12/16
- Product number
- API0019325
- Product name
- GENINTHIOCIN
- Purity
- 95.00%
- Packaging
- 0.5MG
- Price
- $549
- Updated
- 2021/12/16
geninthiocin Chemical Properties,Usage,Production
Description
Geninthiocin A is a cyclic thiopeptide bacterial metabolite originally isolated from Streptomyces sp. DD84. It is active against a variety of Gram-positive bacteria (MICs = 0.2-4 μg/ml), the Gram-negative bacterium C. violaceum (MIC = 19 μg/ml), and the fungus M. hiemalis (MIC = 38 μg/ml). Geninthiocin A also induces tipA promoter transcription with a minimum induction concentration of 1.2 ng/ml.
Uses
Geninthiocin, a thiopeptide antibiotic isolated from a Streptomyces sp., is a potent activator of the tipA gene, a bacterial transcription regulator involved in multidrug resistance. Geninthiocin displays a 10-fold selectivity for bacteria over mammalian cells lines, whereas the related dedialanyl geninthiocin shows the reverse selectivity. Geninthiocin is closely related to siomycin, a recently discovered inhibitor of oncogenic transcription factor, FoxM1.
Uses
Geninthiocin is a thiopeptide antibiotic tipA gene activator.
geninthiocin Preparation Products And Raw materials
Raw materials
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