gallidermin

gallidermin Property

Density 

1.41±0.1 g/cm3(Predicted)

pka

9.89±0.15(Predicted)

form 

White to off-white powder.

Hazard and Precautionary Statements (GHS)

gallidermin Chemical Properties,Usage,Production

Description

Gallidermin is a polypeptide-antimicrobial active substance of proteinaceous characterproduced by Staphylococcus gallinarum TU 3928. This substance belongs to a group of polycyclicproteinaceous substances called bacteriocins. It contains unusual amino acid residues suchas lanthionine, β-methyllanthionine or α, β-didehydroamino acids which are capable to buildintramolecular thioether bridges, therefore those group of bacteriocins is called lantibiotics ^[1].

Uses

Gallidermin is an antibiotic peptide. Lantibiotics are well studied because of the commercial use of these bacteria in the food industry for making dairy products such as cheese. Gallidermin is a tetracyclic, 21-amino-acid, type A lantibi- otic peptide which is produced by the nonpathogenic Staphy- lococcus gallinarum Tu 3928 and shows broad-spectrum activity against important gram-positive pathogens like S. au- reus, Staphylococcus epidermidis, Streptococcus pyogenes, Strep- tococcus pneumoniae, Streptococcus faecalis, and P. acnes .

Biosynthesis

Gallidermin (6L-epidermin) is closely related to epidermin, which is synthesized by the class II strain S. epidermidis Tü3298. The biosynthesis, modification, secretion, and activation of epidermin have been broadly studied. Since gallidermin and epidermin have a high degree of identity on the DNA and protein level, and several genes of the two gene clusters have been shown to be interchangeable, many assumptions on gallidermin biosynthesis and function have been made based on previous research on epidermin.

References

[1] G VALSESIA. Circumventing the effect of product toxicity: development of a novel two-stage production process for the lantibiotic gallidermin.[J]. Applied and Environmental Microbiology, 2007, 73 5: 1635-1645. DOI:10.1128/AEM.01969-06.