ChemicalBook > CAS DataBase List > ETHYL TRIMETHYLACETOPYRUVATE

ETHYL TRIMETHYLACETOPYRUVATE

Product Name: ETHYL TRIMETHYLACETOPYRUVATE
CAS No.: 13395-36-3
Chemical Name: ETHYL TRIMETHYLACETOPYRUVATE
Synonyms: AKOS MSC-0258;-2,4-dioxohexanoate;Ethyl pivaloylpyruvate;Ethyl trimethyacetopyruvate;ETHYL TRIMETHYLACETOPYRUVATE;1ETHYL TRIMETHYLACETOPYRUVATE;Ethyl trimethylacetopyruvate,98%;Ethyl trimethyacetopyruvate, 98+%;3-Pivaloylpyruvic acid ethyl ester;Ethyl-5,5-dimethyl-2,4-dioxohexanoat
CBNumber: CB4133355
Molecular Formula: C10H16O4
Formula Weight: 200.23
MOL File: 13395-36-3.mol

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ETHYL TRIMETHYLACETOPYRUVATE Property

Boiling point:: 64 °C
Density: 1.046±0.06 g/cm3(Predicted)
refractive index: 1.4700
Flash point:: 68-70°C/0.5mm
storage temp.: 2-8°C
form: clear liquid
pka: 6.98±0.46(Predicted)
color: Light yellow to Brown
BRN: 510374
InChI: InChI=1S/C10H16O4/c1-5-14-9(13)7(11)6-8(12)10(2,3)4/h5-6H2,1-4H3
InChIKey: NIMKIMUBJFWPTD-UHFFFAOYSA-N
SMILES: C(OCC)(=O)C(=O)CC(=O)C(C)(C)C
CAS DataBase Reference: 13395-36-3

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Safety

Hazard Codes: Xi
Safety Statements: 23-24/25
HazardClass: IRRITANT
HS Code: 2934999090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TCI Chemical

Product number: E1326
Product name: Ethyl Trimethylacetopyruvate
Purity: >98.0%(GC)
Packaging: 1g
Price: $82
Updated: 2025/07/31

TCI Chemical

Product number: E1326
Product name: Ethyl Trimethylacetopyruvate
Purity: >98.0%(GC)
Packaging: 5g
Price: $251
Updated: 2025/07/31

Usbiological

Product number: 449466
Product name: Ethyl 5,5-dimethyl-2,4-dioxohexanoate
Packaging: 100mg
Price: $305
Updated: 2021/12/16

TRC

Product number: E917438
Product name: Ethyl5,5-dimethyl-2,4-dioxohexanoate
Packaging: 100mg
Price: $45
Updated: 2021/12/16

TRC

Product number: E917438
Product name: Ethyl5,5-dimethyl-2,4-dioxohexanoate
Packaging: 500mg
Price: $65
Updated: 2021/12/16

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ETHYL TRIMETHYLACETOPYRUVATE Chemical Properties,Usage,Production

Synthesis

75-97-8

95-92-1

13395-36-3

A mixture of pinacolone (740 mmol) and diethyl oxalate (820 mmol) was added dropwise to a solution of sodium ethoxide (prepared by dissolving 740 mmol of sodium in 450 mL of ethanol) at room temperature, followed by stirring the reaction for 1 hour at 78 °C. Upon completion of the reaction, the reaction mixture was cooled to room temperature and slowly poured into a pre-cooled aqueous 5 M hydrochloric acid solution (800 mL). Extraction was carried out with methyl tert-butyl ether (300 mL each time, 3 times in total), and the combined organic phases were washed with saturated aqueous sodium chloride solution (500 mL) and dried over anhydrous sodium sulfate. After filtration, the solvent was removed by distillation under reduced pressure to afford the target product ethyl 5,5-dimethyl-2,4-dioxohexanoate as a red liquid. Product weight: 140 g, yield: 93.3%. Mass spectrum (ES+): m/z 199 ([M+H]+). Nuclear magnetic resonance hydrogen spectrum (1H NMR, CDCl3): δ 6.5 (1H, s, CH), 4.3 (2H, q, OCH2), 1.35 (3H, t, CH3), 1.15 (9H, s, 3×CH3).

References

[1] Bioorganic and Medicinal Chemistry Letters, 2017, vol. 27, # 18, p. 4383 - 4388
[2] Journal of Organic Chemistry, 1997, vol. 62, # 17, p. 5908 - 5919
[3] Patent: WO2009/71707, 2009, A1. Location in patent: Page/Page column 43
[4] Chinese Chemical Letters, 2016, vol. 27, # 4, p. 566 - 570
[5] Chinese Chemical Letters, 2016, vol. 27, # 2, p. 251 - 255

ETHYL TRIMETHYLACETOPYRUVATE Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from ETHYL TRIMETHYLACETOPYRUVATE manufacturers

Career Henan Chemical Co

Product: 1ETHYL TRIMETHYLACETOPYRUVATE 13395-36-3
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98%-99.9%
Supply Ability: 100kg
Release date: 2020-01-10

13395-36-3, ETHYL TRIMETHYLACETOPYRUVATERelated Search:

2,2-DIMETHYL-3,5-HEXANEDIONE 2-Oxobutyric acid ETHYL PROPIONYL PYRUVATE ethyl 5-methyl-2,4-dioxohexanoate Ethyl 2,4-dioxovalerate METHYL ACETOPYRUVATE Ethyl levulinate Ethyl 2-oxovalerate Ethyl 3-oxobutanoate sodium salt Ethyl 2-oxohexanoate ETHYL TRIMETHYLACETOPYRUVATE Ethyl pyruvate METHYL 2-OXOVALERATE 5,5-DIMETHYL-4-OXOHEXANOIC ACID ETHYL 5-METHYL-4-OXOHEXANOATE Ethyl-4-oxohexanoate 4-OXO-HEXANOIC ACID 5-methyl-4-oxo-hexanoic acid

Ethyl-5,5-dimethyl-2,4-dioxohexanoat

Ethyl trimethyacetopyruvate, 98+%

2,4-Dioxo-5,5-dimethylhexanoic acid ethyl ester

3-Pivaloylpyruvic acid ethyl ester

Ethyl 5, 5-dimethyl2, 4-dioxo-1-hexanoate

5,5-Dimethyl-2,4-dioxo-hexanoic acid ethyl ester

(Z)-ethyl 2-hydroxy-5,5-diMethyl-4-oxohex-2-enoate

Ethyl (trimethylacetyl)pyruvate, Ethyl 5,5-dimethyl-2,4-dioxocaproate

Ethyl 2,4-dioxo-5,5-dimethylhexanoate

Ethyl pivaloylpyruvate

AKOS MSC-0258

ETHYL 5,5-DIMETHYL-2,4-DIOXOHEXANOATE

ETHYL TRIMETHYLACETOPYRUVATE

Ethyl 5,5-dimethyl-2,4-dioxohexanoate~Trimethylacetopyruvic acid ethyl ester

trimethylacetopyruvic acid ethyl ester

1ETHYL TRIMETHYLACETOPYRUVATE

Hexanoic acid, 5,5-dimethyl-2,4-dioxo-, ethyl ester

-2,4-dioxohexanoate

Ethyl trimethylacetopyruvate,98%

5,5-Dimethyl-2,4-Dioxo hexonoic acid ethyl ester [Pinacolone Stage I]

Ethyl trimethyacetopyruvate

13395-36-3