ETHYL TRIMETHYLACETOPYRUVATE

ETHYL TRIMETHYLACETOPYRUVATE Property

Boiling point:

64 °C

Density 

1.046±0.06 g/cm3(Predicted)

refractive index 

1.4700

Flash point:

68-70°C/0.5mm

storage temp. 

2-8°C

form 

clear liquid

pka

6.98±0.46(Predicted)

color 

Light yellow to Brown

BRN 

510374

InChI

InChI=1S/C10H16O4/c1-5-14-9(13)7(11)6-8(12)10(2,3)4/h5-6H2,1-4H3

InChIKey

NIMKIMUBJFWPTD-UHFFFAOYSA-N

SMILES

C(OCC)(=O)C(=O)CC(=O)C(C)(C)C

CAS DataBase Reference

13395-36-3

Safety

Hazard Codes 

Xi

Safety Statements 

23-24/25

HazardClass 

IRRITANT

HS Code 

2934999090

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P501Dispose of contents/container to..…

ETHYL TRIMETHYLACETOPYRUVATE Chemical Properties,Usage,Production

Synthesis

A mixture of pinacolone (740 mmol) and diethyl oxalate (820 mmol) was added dropwise to a solution of sodium ethoxide (prepared by dissolving 740 mmol of sodium in 450 mL of ethanol) at room temperature, followed by stirring the reaction for 1 hour at 78 °C. Upon completion of the reaction, the reaction mixture was cooled to room temperature and slowly poured into a pre-cooled aqueous 5 M hydrochloric acid solution (800 mL). Extraction was carried out with methyl tert-butyl ether (300 mL each time, 3 times in total), and the combined organic phases were washed with saturated aqueous sodium chloride solution (500 mL) and dried over anhydrous sodium sulfate. After filtration, the solvent was removed by distillation under reduced pressure to afford the target product ethyl 5,5-dimethyl-2,4-dioxohexanoate as a red liquid. Product weight: 140 g, yield: 93.3%. Mass spectrum (ES+): m/z 199 ([M+H]+). Nuclear magnetic resonance hydrogen spectrum (1H NMR, CDCl3): δ 6.5 (1H, s, CH), 4.3 (2H, q, OCH2), 1.35 (3H, t, CH3), 1.15 (9H, s, 3×CH3).

References

[1] Bioorganic and Medicinal Chemistry Letters, 2017, vol. 27, # 18, p. 4383 - 4388
[2] Journal of Organic Chemistry, 1997, vol. 62, # 17, p. 5908 - 5919
[3] Patent: WO2009/71707, 2009, A1. Location in patent: Page/Page column 43
[4] Chinese Chemical Letters, 2016, vol. 27, # 4, p. 566 - 570
[5] Chinese Chemical Letters, 2016, vol. 27, # 2, p. 251 - 255