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aureothricin

Product Name
aureothricin
CAS No.
574-95-8
Chemical Name
aureothricin
Synonyms
Propionylpyrrothione, Farcinin;5-Methyl-3-propionamidopyrrolin-4-one-[4,3-d]-1,2-dithiole;N-(4,5-Dihydro-4-methyl-5-oxo-1,2-dithiolo[4,3-b]pyrrol-6-yl)propanamide;N-(4,5-Dihydro-4-methyl-5-oxo-1,2-dithiolo[4,3-b]pyrrol-6-yl)propionamide;Propanamide, N-(4,5-dihydro-4-methyl-5-oxo-1,2-dithiolo[4,3-b]pyrrol-6-yl)-;Propionopyrrothine, 5-Methyl-3-propionamidopyrrolin-4-one[4,3-d]-1,2-dithiole
CBNumber
CB41334476
Molecular Formula
C9H10N2O2S2
Formula Weight
242.32
MOL File
574-95-8.mol
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aureothricin Property

Melting point:
260-270℃ (decomposition)
Boiling point:
479.1±45.0 °C(Predicted)
Density 
1.48±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMF: soluble; DMSO: soluble; Ethanol: partially soluble; Methanol: partially soluble
pka
10.54±0.20(Predicted)
form 
Yellow to orange solid.
color 
Yellow
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Safety

HS Code 
29419090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
19942
Product name
Aureothricin
Purity
≥98%
Packaging
500μg
Price
$141
Updated
2024/03/01
Cayman Chemical
Product number
19942
Product name
Aureothricin
Purity
≥98%
Packaging
1mg
Price
$239
Updated
2024/03/01
Cayman Chemical
Product number
19942
Product name
Aureothricin
Purity
≥98%
Packaging
5mg
Price
$769
Updated
2024/03/01
TRC
Product number
A794573
Product name
Aureothricin
Packaging
1mg
Price
$1000
Updated
2021/12/16
TRC
Product number
A794573
Product name
Aureothricin
Packaging
0.5mg
Price
$525
Updated
2021/12/16
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aureothricin Chemical Properties,Usage,Production

Uses

Aureothricin is an antibiotic first described by Umezawa and co-workers in Japan in 1949. Resurgent interest in this class of microbial metabolites was stimulated by the discovery of their selective antitumour activity. Aureothricin is a more hydrophobic analogue of thiolutin, but has received only limited attention. Members of this class, notably thiolutin, are potent inhibitors of bacterial and yeast RNA polymerases, inhibitors of mannan and glucan formation in fungi, and inhibitors of tumour-cell induced angiogenesis in vivo.

Definition

ChEBI: Aureothricin is a dithiolopyrrolone antibiotic that is 4,5-dihydro[1,2]dithiolo[4,3-b]pyrrole in which the hydrogens at positions 4,5 and 6 have been replaced by methyl, oxo and propanoylamino groups, respectively. It is a moderate antimicrobial by-product of the thiolutin fermentation in various Streptomyces species. It has a role as a bacterial metabolite, an angiogenesis inhibitor, an antibacterial agent and an EC 2.7.7.6 (RNA polymerase) inhibitor. It is a dithiolopyrrolone antibiotic and a secondary carboxamide.

storage

+4°C

aureothricin Preparation Products And Raw materials

Raw materials

Preparation Products

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aureothricin Suppliers

BOC Sciences
Tel
16314854226; +16314854226
Email
inquiry@bocsci.com
Country
United States
ProdList
19741
Advantage
58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354 +1-00000000000
Email
marketing@targetmol.com
Country
United States
ProdList
32161
Advantage
58
TargetMol Chemicals Inc.
Tel
Email
support@targetmol.com
Country
United States
ProdList
38631
Advantage
58
Cayman Chemical Company
Tel
--
Fax
--
Email
cayman@caymanchem.com
Country
United States
ProdList
6213
Advantage
81
MedChemExpress
Tel
--
Fax
--
Email
sales@medchemexpress.com
Country
United States
ProdList
6398
Advantage
58

574-95-8, aureothricinRelated Search:


  • N-(4,5-Dihydro-4-methyl-5-oxo-1,2-dithiolo[4,3-b]pyrrol-6-yl)propanamide
  • N-(4,5-Dihydro-4-methyl-5-oxo-1,2-dithiolo[4,3-b]pyrrol-6-yl)propionamide
  • Propionopyrrothine, 5-Methyl-3-propionamidopyrrolin-4-one[4,3-d]-1,2-dithiole
  • Propionylpyrrothione, Farcinin
  • 5-Methyl-3-propionamidopyrrolin-4-one-[4,3-d]-1,2-dithiole
  • Propanamide, N-(4,5-dihydro-4-methyl-5-oxo-1,2-dithiolo[4,3-b]pyrrol-6-yl)-
  • 574-95-8
  • antibiotic