OXOTREMORINE Property

Melting point:

<25 °C

Boiling point:

124 °C0.1 mm Hg(lit.)

Density 

1 g/mL at 25 °C(lit.)

refractive index 

n20/D 1.517(lit.)

Flash point:

113 °C

storage temp. 

2-8°C

solubility 

H₂O: 50 mg/mL

form 

liquid

pka

8.29±0.20(Predicted)

color 

clear, light yellow

Merck 

13,7020

Safety

Hazard Codes 

T+,C

Risk Statements 

28-34

Safety Statements 

26-36/37/39-45

RIDADR 

UN 2810 6.1/PG 1

WGK Germany 

3

RTECS 

UY5950100

F 

10-23

HazardClass 

6.1(a)

PackingGroup 

I

Toxicity

LD50 ipr-rat: 4400 mg/kg TXAPA9 14,67,69

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H300Fatal if swallowed

H314Causes severe skin burns and eye damage

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P310Immediately call a POISON CENTER or doctor/physician.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P363Wash contaminated clothing before reuse.

P405Store locked up.

P501Dispose of contents/container to..…

OXOTREMORINE Chemical Properties,Usage,Production

Definition

ChEBI: Oxotremorine is a N-alkylpyrrolidine.

General Description

Oxotremorine [1-(-pyrrolidono)-4-pyrrolidino-2-butyne] has been regarded as a CNS muscarinicstimulant. Its action on the brain produces tremors inexperimental animals. It increases ACh brain levels in ratsup to 40% and has been studied as a drug in the treatment ofAlzheimer disease. Although earlier studies suggested thatthis approach of elevating levels of ACh to treat Alzheimerdisease is useful, this belief was highly disputed by manyresearchers.

Clinical Use

Nevertheless, oxotremorine, as a cholinergicagonist, facilitates memory storage. These findings haveserved as important leads in the development of agents usefulin treating Alzheimer disease. Although it possessesgroups that do not occur in other highly active muscarinicagents, oxotremorine’s trans conformation shows that distancesbetween possible active centers correspond with (+)-muscarine.

Safety Profile

Poison by ingestion and intraperitoneal routes. Moderately toxic by intravenous route. When heated to decomposition it emits toxic fumes of NOx.