2-(Hydroxymethyl)pyrrolidine
- Product Name
- 2-(Hydroxymethyl)pyrrolidine
- CAS No.
- 498-63-5
- Chemical Name
- 2-(Hydroxymethyl)pyrrolidine
- Synonyms
- prolinol;2-Pyrrolidinemethanol;Pyrrolidine, 2-(hydroxymethyl)-;NSC 367102;rac-Prolinol;DL-Prolinol>Pyrrolidine-2-methanol;2-Pyrrolidinylmethanol;2-(Hydroxymethyl)pyrrolidine;pyrrolidin-2-ylmethanol(SALTDATA: FREE)
- CBNumber
- CB41370586
- Molecular Formula
- C5H11NO
- Formula Weight
- 101.15
- MOL File
- 498-63-5.mol
2-(Hydroxymethyl)pyrrolidine Property
- Boiling point:
- 98 °C / 14mmHg
- Density
- 1.04
- refractive index
- 1.4840
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- solubility
- Soluble in ethanol.
- pka
- 14.77±0.10(Predicted)
- form
- clear liquid
- color
- Colorless to Light orange to Yellow
- optical activity
- Consistent with structure
Safety
- HS Code
- 2933998090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- CDS000339
- Product name
- 2-Pyrrolidinylmethanol
- Purity
- AldrichCPR
- Packaging
- 500mg
- Price
- $73.1
- Updated
- 2025/07/31
- Product number
- P1793
- Product name
- DL-Prolinol
- Purity
- >95.0%(GC)(T)
- Packaging
- 5g
- Price
- $112
- Updated
- 2025/07/31
- Product number
- P1793
- Product name
- DL-Prolinol
- Purity
- >95.0%(GC)(T)
- Packaging
- 25g
- Price
- $382
- Updated
- 2025/07/31
- Product number
- P756010
- Product name
- rac-Prolinol
- Packaging
- 10g
- Price
- $1100
- Updated
- 2021/12/16
- Product number
- W6534
- Product name
- DL-Prolinol
- Packaging
- 500g
- Price
- $1174
- Updated
- 2021/12/16
2-(Hydroxymethyl)pyrrolidine Chemical Properties,Usage,Production
Uses
rac-Prolinol is an intermediate in the synthesis of Physostigmine and Physostigmine derivative used for treatment of Alzheimer''s disease.
Uses
2-(Hydroxymethyl)pyrrolidine is an intermediate in the synthesis of Physostigmine and Physostigmine derivative used for treatment of Alzheimer's disease.
Definition
2-(Hydroxymethyl)pyrrolidine is an amino alcohol formed by reduction of the amino acid proline.
Synthesis
609-36-9
498-63-5
General procedure for the synthesis of pyrrolidine-2-methanol from DL-proline: DL-proline (6.0 g, 52.0 mmol) was slowly added in batches to a THF (80 mL) suspension of LiAlH4 (3.0 g, 78.0 mmol) under stirring at 0 °C and nitrogen protection, and the addition process was controlled to be completed within 30 min. The reaction mixture was gradually warmed up to room temperature and then continued to be heated and refluxed for 3 hours. Upon completion of the reaction, a 20% KOH solution (18-20 mL) was slowly added at 0 °C to quench the reaction. The mixture was filtered through a Celite pad and the filter cake was washed with THF. The solid obtained by filtration was again mixed with THF and filtered at reflux for 30 min. All the filtrates were combined and concentrated to give the light yellow liquid product K1 (3.2 g, 65% yield), which gradually transformed to a dark brown liquid during storage. The Rf value of the product was 0.1 (unfolding agent: DCM solution of 10% MeOH containing 1 drop of AcOH, ninhydrin color developed).
References
[1] Tetrahedron, 2010, vol. 66, # 40, p. 7970 - 7974
[2] Patent: WO2015/181676, 2015, A1. Location in patent: Page/Page column 166-167
[3] Patent: WO2011/22508, 2011, A2. Location in patent: Page/Page column 59
[4] Hoppe-Seyler's Zeitschrift fuer Physiologische Chemie, 1931, vol. 203, p. 279,285
[5] Monatshefte fuer Chemie, 1952, vol. 83, p. 541
2-(Hydroxymethyl)pyrrolidine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-(Hydroxymethyl)pyrrolidine manufacturers
- Product
- 2-(Hydroxymethyl)pyrrolidine 498-63-5
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 200kg
- Release date
- 2020-01-08