DL-Proline

Product Name: DL-Proline
CAS No.: 609-36-9
Chemical Name: DL-Proline
Synonyms: PYRROLIDINE-2-CARBOXYLIC ACID;H-DL-PRO-OH;DL-Pro;DL-Prolin;DL-Pro-OH;DL-PROLINE;Proline, DL-;(RS)-Proline;DL-Proline>DL-Proline,99%
CBNumber: CB4149769
Molecular Formula: C5H9NO2
Formula Weight: 115.13
MOL File: 609-36-9.mol

More

Less

DL-Proline Property

Melting point:: 208 °C (dec.) (lit.)
Boiling point:: 215.41°C (rough estimate)
Density: 1.1808 (rough estimate)
refractive index: 1.4538 (estimate)
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
solubility: Methanol, Water
pka: 2.35±0.20(Predicted)
form: Crystalline Powder
color: White to off-white
Water Solubility: SOLUBLE
Merck: 14,7780
BRN: 80809
Major Application: peptide synthesis
Cosmetics Ingredients Functions: SKIN CONDITIONING
HAIR CONDITIONING
InChI: 1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)
InChIKey: ONIBWKKTOPOVIA-UHFFFAOYSA-N
SMILES: OC(=O)C1CCCN1
CAS DataBase Reference: 609-36-9(CAS DataBase Reference)
NIST Chemistry Reference: DL-Proline(609-36-9)
EPA Substance Registry System: Proline (609-36-9)

More

Less

Safety

Hazard Codes: Xn
Risk Statements: 22-36/37/38
Safety Statements: 22-24/25-36/37/39-26
WGK Germany: 3
F: 3-10
TSCA: TSCA listed
HS Code: 29339990
Storage Class: 11 - Combustible Solids

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

More

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 171824
Product name: DL-Proline
Purity: ReagentPlus , 99%
Packaging: 1g
Price: $36.5
Updated: 2025/07/31

Sigma-Aldrich

Product number: 171824
Product name: DL-Proline
Purity: ReagentPlus , 99%
Packaging: 5g
Price: $46.2
Updated: 2025/07/31

TCI Chemical

Product number: P0480
Product name: DL-Proline
Purity: >99.0%(T)
Packaging: 1g
Price: $24
Updated: 2025/07/31

TCI Chemical

Product number: P0480
Product name: DL-Proline
Purity: >99.0%(T)
Packaging: 5g
Price: $41
Updated: 2025/07/31

Sigma-Aldrich

Product number: 171824
Product name: DL-Proline
Purity: ReagentPlus , 99%
Packaging: 25g
Price: $129
Updated: 2025/07/31

More

Less

DL-Proline Chemical Properties,Usage,Production

Chemical Properties

white to off-white crystalline powder

Uses

DL-Proline is the racemic mixture of both L-Proline (P755995) and D-Proline (P755990).

Definition

ChEBI: An alpha-amino acid that is pyrrolidine bearing a carboxy substituent at position 2.

reaction suitability

reaction type: solution phase peptide synthesis

Synthesis

Input 100g of glacial acetic acid into the reaction kettle, and then input 100g of L-proline under stirring to obtain the reaction solution. After the reaction solution was stirred and warmed to 70-75??C, it was kept warm and stirred for 3h to make the L-proline fully racemic, which in turn made the reaction solution have a spin of 0, and at this time, the reaction solution was reddish-brown in color.

The reaction solution with spin 0 was cooled to 30 ??, and then moved to the distillation kettle for distillation under reduced pressure, the temperature of distillation was at 55-60 ??, the vapor pressure was 0.1MPa, and the distillation was continued for 30min after distillation until there was no liquid effluent, and then the residue of distillation was concentrated to 10% of the original volume to obtain the viscous concentrate A.

The concentrate A was mixed with 120g of isopropanol, stirred until the crystals precipitated completely, then cooled down to 15??C, centrifuged to remove excess liquid, and the crystals were rinsed with isopropanol to obtain the crude product.

Mix 90g of crude product, 5g of activated carbon, 185g of water and stir to raise the temperature to 70??, keep warm and stir for 30min to make the crude product dissolve completely, then filter to remove the activated carbon. The residue without activated carbon after filtration was concentrated to 20% of the original volume to obtain a viscous concentrate B.

The concentrate B was mixed with 285g of isopropanol, stirred until the crystals precipitated completely, then cooled to 15??C, centrifuged to remove the excess liquid, rinsed the crystals with isopropanol, and after rinsing, the crystals were dried at 80??C for 12h to obtain the sample of DL-proline.

DL-Proline Preparation Products And Raw materials

Raw materials

L-Proline

Preparation Products

H-DL-PRO-OME HCL

More

Less

DL-Proline Suppliers

Americas 1 Austria 1 Belgium 2 Canada 1 China 357 Europe 1 France 3 Germany 6 Hungary 1 India 11 Japan 6 Poland 1 South Korea 1 Switzerland 6 Ukraine 1 United Kingdom 16 United States 50 USA 1 Global 466

Huaibei Desung Biotech Co., Ltd.

Tel: 0561-2337889 13515618601
Email: 390478052@qq.com
Country: China
ProdList: 1821
Advantage: 58

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Meryer (Shanghai) Chemical Technology Co., Ltd.

Tel: 4006356688 18621169109
Fax: 86-21-61259102
Email: market03@meryer.com
Country: China
ProdList: 40228
Advantage: 62

Alfa Aesar

Tel: 400-6106006
Fax: 021-67582001/03/05
Email: saleschina@alfa-asia.com
Country: China
ProdList: 30123
Advantage: 84

TCI (Shanghai) Development Co., Ltd.

Tel: 021-67121386
Fax: 021-67121385
Email: Sales-CN@TCIchemicals.com
Country: China
ProdList: 24529
Advantage: 81

ShangHai DEMO Chemical Co.,Ltd

Tel: 400-021-7337 2355568890
Fax: 0086-21-50182339
Email: sales@demochem.com
Country: China
ProdList: 2572
Advantage: 57

Beijing HwrkChemical Technology Co., Ltd

Tel: 010-89508211 18501085097
Fax: 010-89508210
Email: sales.bj@hwrkchemical.com
Country: China
ProdList: 9401
Advantage: 55

Energy Chemical

Tel: 021-021-58432009 400-005-6266
Fax: 021-58436166
Email: sales8178@energy-chemical.com
Country: China
ProdList: 44801
Advantage: 61

GL Biochem (Shanghai) Ltd

Tel: 21-61263452 13641803416
Fax: 86-21-61263399
Email: ymbetter@glbiochem.com
Country: China
ProdList: 9981
Advantage: 64

Beijing Ouhe Technology Co., Ltd

Tel: 010-010-82967028 13522913783
Fax: +86-10-82967029
Email: 2355560935@qq.com
Country: China
ProdList: 11999
Advantage: 60

More

Less

View Lastest Price from DL-Proline manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: DL-Proline 609-36-9
Price: US $0.00-0.00/Kg/Drum
Min. Order: 1KG
Purity: 98.0%-101.0%
Supply Ability: 10 TONS
Release date: 2021-06-05

Sichuan HongRi Pharma-Tech Co.,Ltd

Product: DL-Pro-OH 609-36-9
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 1T+
Release date: 2023-09-20

Hebei Chuanghai Biotechnology Co., Ltd

Product: DL-Proline 609-36-9
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 mt
Release date: 2025-03-11

609-36-9, DL-ProlineRelated Search:

D-Proline L-PROLINE-(4-3H(N)) Ethyl 2-(Chlorosulfonyl)acetate L-Proline Pyrrolidine GLYCYL-L-PROLINE Ascoric Acid cis-4-Hydroxy-L-proline BOC-L-Proline N-(2,4-DINITROPHENYL)-L-PROLINE Cyclopentene oxide Fmoc-Pro-OH Methyl L-prolinate hydrochloride Ethyl D-(-)-pyroglutamate BOC-HYP(BZL)-OH cis-4-Hydroxy-D-proline N-Methyl-L-proline N-Cbz-Hydroxy-L-proline

H-DL-PYRD(2)-OH

H-DL-PRO-OH

LABOTEST-BB LTBB000673

DL-Proline ReagentPlus(R), 99%

DL-PROLINE

DL-Proline Vetec(TM) reagent grade, 98%

DL-Pro-OH

DL-Proline≥ 99% (Assay)

(2R)-2-pyrrolidin-1-iumcarboxylate

DL-2-Pyrrolidinocarboxylic acid

(+/-)-PYRROLIDINE-2-CARBOXYLIC ACID

PYRROLIDINE-2-CARBOXYLIC ACID

Proline, DL-

DL-PYRROLIDINE-2-CARBOXYLIC ACID

DL-2-PYRROLIDINECARBOXYLIC ACID

H-DL-Pro-OH~(+/-)-Pyrrolidine-2-carboxylic acid

ProlinePyrrolidinecarboxylicacid

(R,S)-Pyrrolidine-2-carboxylic acid

DL-Proline,99%

(n)-pyrrolidine-2-carboxylic acid

DL-Prolin

DL-Proline, 99% 5GR

(RS)-Proline

rac-(2R*)-Pyrrolidine-2-carboxylic acid

rac-(2R*)-Pyrrolidine-2β*-carboxylic acid

PROGOITRIN(RG)

DL-Proline,(±)-Pyrrolidine-2-carboxylic acid

DL-Pro

DL-Proline&gt

DL-Proline USP/EP/BP

dextro,laevo-proline

Proline reference substance

Prinomastat Impurity 2

<sc>DL</sc>-Proline

609-36-9

156-2-48

C5H9N1O2

C5H10NO2

NC4H8COOH

Peptide Synthesis

Specialty Synthesis

CARBOXYLIC ACID

Amino Acid Derivatives

Proline [Pro, P]

Amino Acids and Derivatives

alpha-Amino Acids

Amino Acids

Biochemistry

Amino Acids

Pyridines