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N-Methyl-L-proline

Product Name
N-Methyl-L-proline
CAS No.
475-11-6
Chemical Name
N-Methyl-L-proline
Synonyms
N-METHYL-L-PROLINE;N-Methylproline;N-ME-PRO-OH;1-Methyl-L-proline;Hygric acid;N-ME-PROLINE;Hygrinic acid;N-Me-L-Pro-OH;PYRD(2)-OH H2O;H-MEPRO-OH H2O
CBNumber
CB1179181
Molecular Formula
C6H11NO2
Formula Weight
129.16
MOL File
475-11-6.mol
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N-Methyl-L-proline Property

Melting point:
114-116 °C(lit.)
Boiling point:
227℃
Density 
1.153
Flash point:
91.1℃
refractive index 
1.5000
storage temp. 
Sealed in dry,Store in freezer, under -20°C
solubility 
Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
pka
2.37±0.20(Predicted)
form 
Powder
color 
White to off-white
Water Solubility 
Soluble in water and methanol(both 50 mg/ml-clear-colorless solution)
InChI
InChI=1S/C6H11NO2/c1-7-4-2-3-5(7)6(8)9/h5H,2-4H2,1H3,(H,8,9)/t5-/m0/s1
InChIKey
CWLQUGTUXBXTLF-YFKPBYRVSA-N
SMILES
C(O)(=O)[C@@H]1CCCN1C
CAS DataBase Reference
475-11-6
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Safety

WGK Germany 
3
HazardClass 
IRRITANT
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P233Keep container tightly closed.

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304IF INHALED:

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P340Remove victim to fresh air and keep at rest in a position comfortable for breathing.

P362Take off contaminated clothing and wash before reuse.

P403Store in a well-ventilated place.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
M8021
Product name
N-Methyl-L-proline
Packaging
500mg
Price
$489
Updated
2023/06/20
Sigma-Aldrich
Product number
M8021
Product name
N-Methyl-L-proline
Packaging
1g
Price
$844
Updated
2023/06/20
Alfa Aesar
Product number
H63241
Product name
N-Methyl-L-proline, 98%
Packaging
1g
Price
$347
Updated
2021/12/16
Alfa Aesar
Product number
H63241
Product name
N-Methyl-L-proline, 98%
Packaging
250mg
Price
$117
Updated
2021/12/16
Usbiological
Product number
240080
Product name
N-Methyl-L-proline, 98%
Packaging
250mg
Price
$206
Updated
2021/12/16
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N-Methyl-L-proline Chemical Properties,Usage,Production

Uses

N-Methyl-L-proline, is an aminoacid which is widely used in pharmaceuticals and food industry.

Definition

ChEBI: N-methylproline is an L-proline derivative obtained by replacement of the amino hydrogen by a methyl group. It has a role as a plant metabolite and a human metabolite. It is a L-proline derivative and a tertiary amino compound. It is a tautomer of a N-methylproline zwitterion.

Synthesis

L-Proline 86 (2.0 g, 17.4 mmol) was dissolved in methanol (20 mL) and to this solution was added 40% aqueous formaldehyde solution (1.4 mL, 19.1 mmol). This was followed by the addition of 10% palladiumon-charcoal catalyst (500 mg) and the resulting slurry was stirred in a hydrogen atmosphere overnight. The slurry was then filtered through a Celite pad to remove the catalyst. The pad was washed with methanol and the combined filtrates were concentrated under reduced pressure. The residue was taken up in ethanol-benzene (1:1, 100 mL) and concentrated a second time to provide a solid, which was recrystallized from methanol-diethyl ether. In this way N-Methyl-L-proline was isolated as fine needles (2.2 g, 98%). Mp 142-145 °C. [α]23 D -78.0° (c 2.0, MeOH). 1H NMR (300 MHz, D2O) δ 3.71-3.65 and 3.55-3.51 (2m, 1H), 3.00-2.91 (m, 1H), 2.74 (s, 3H), 2.34-2.28 (m, 1H), 1.99-1.78 (m, 3H). 13C NMR (75 MHz, CDCl3) δ 173.06, 70.18, 55.83, 40.26, 28.34, 22.37. IR (KBr disk) ν 3000-2800 (CH, saturated), 2675 and 2605 (ammonium ion), 1669 (CO2H), 1612 (CO2 -), 1468, 1401, 1354, 1327, 1234, 1183, 1112, 1056, 1025, 808, 775 cm-1. HRMS calcd for C6H11NO2 (M+) 129.0790, found 129.0784.

N-Methyl-L-proline Preparation Products And Raw materials

Raw materials

Preparation Products

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N-Methyl-L-proline Suppliers

Shanghai Boyle Chemical Co., Ltd.
Tel
021-50182298 021-50180596
Fax
+86-21-57758967
Email
sales@boylechem.com
Country
China
ProdList
2208
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55
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
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China
ProdList
94657
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Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
021-61259108 18621169109
Fax
86-21-61259102
Email
market03@meryer.com
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China
ProdList
40228
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3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
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China
ProdList
15839
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Alabiochem Tech.Co., Ltd.
Tel
0512-58900862 400-0707518
Fax
0086-512-56765862
Email
sales@alabiochem.com
Country
China
ProdList
995
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59
Alfa Aesar
Tel
400-6106006
Fax
021-67582001/03/05
Email
saleschina@alfa-asia.com
Country
China
ProdList
30123
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84
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44689
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Wuhan Chemwish Technology Co., Ltd
Tel
86-027-67849912
Fax
86-027-87531808
Email
sales@chemwish.com
Country
China
ProdList
35896
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56
Shanghai Qiude Biochemical Engineering Co., Ltd
Tel
021-37285021 13472570865;
Fax
86-021-51714507
Email
info@pure-chiral.com
Country
China
ProdList
303
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64
Shanghai Hanhong Scientific Co.,Ltd.
Tel
021-54306202 13764082696
Email
info@hanhongsci.com
Country
China
ProdList
42958
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64
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View Lastest Price from N-Methyl-L-proline manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
N-Methyl-L-proline 475-11-6
Price
US $1.00-22.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
100000KG
Release date
2024-08-02
Hebei Mojin Biotechnology Co., Ltd
Product
N-METHYL-L-PROLINE MONOHYDRATE 475-11-6
Price
US $100.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
5000kg/week
Release date
2021-06-09
Honest Joy Holdings Limited
Product
N-Methyl-l-proline 475-11-6
Price
US $0.00/KG
Min. Order
1KG
Purity
97.8%
Supply Ability
100 tons
Release date
2022-02-18

475-11-6, N-Methyl-L-prolineRelated Search:


  • N-ME-L-PROLINE HYDROCHLORIDE
  • N-ME-PROLINE
  • N-ME-PRO-OH
  • N-ME-PRO-OH HCL
  • N-METHYL-L-PROLINE
  • N-METHYL-L-PROLINE MONOHYDRATE
  • PYRD(2)-OH H2O
  • N-ALPHA-METHYL-L-PROLINE
  • N-ALPHA-METHYL-L-PROLINE HYDRATE
  • N-ALPHA-METHYL-L-PYRROLIDINE-2-CARBOXYLIC ACID HYDRATE
  • MEPYRD(2)-OH H2O
  • H-MEPRO-OH H2O
  • 1-Methyl-L-proline
  • 1-Methylproline
  • Hygric acid
  • N-Methylproline
  • (2S)-1-Methylpyrrolidine-2-carboxylic acid
  • (-)-Hygrinic acid
  • (2S)-1-Methyl-2-pyrrolidinecarboxylic acid
  • Hygrinic acid
  • tert-butyl N-[4-(aminomethyl)cyclohexyl]carbamate,hydrochloride
  • N-Me-L-Pro-OH
  • N-Methyl-L-proline98+%
  • N-METHYL-L-PROLINE MONOHYDRATE HCL
  • L-Proline, 1-methyl-
  • N-METHYL-L-PROLINE MONOHYDRATE USP/EP/BP
  • 475-11-6
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  • BioChemical
  • Amino Acids and Peptides
  • amino acids
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