N-Methyl-L-proline
- Product Name
- N-Methyl-L-proline
- CAS No.
- 475-11-6
- Chemical Name
- N-Methyl-L-proline
- Synonyms
- N-METHYL-L-PROLINE;N-Methylproline;N-ME-PRO-OH;1-Methyl-L-proline;Hygric acid;N-ME-PROLINE;Hygrinic acid;N-Me-L-Pro-OH;PYRD(2)-OH H2O;H-MEPRO-OH H2O
- CBNumber
- CB1179181
- Molecular Formula
- C6H11NO2
- Formula Weight
- 129.16
- MOL File
- 475-11-6.mol
N-Methyl-L-proline Property
- Melting point:
- 114-116 °C(lit.)
- Boiling point:
- 227℃
- Density
- 1.153
- Flash point:
- 91.1℃
- refractive index
- 1.5000
- storage temp.
- Sealed in dry,Store in freezer, under -20°C
- solubility
- Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
- pka
- 2.37±0.20(Predicted)
- form
- Powder
- color
- White to off-white
- Water Solubility
- Soluble in water and methanol(both 50 mg/ml-clear-colorless solution)
- InChI
- InChI=1S/C6H11NO2/c1-7-4-2-3-5(7)6(8)9/h5H,2-4H2,1H3,(H,8,9)/t5-/m0/s1
- InChIKey
- CWLQUGTUXBXTLF-YFKPBYRVSA-N
- SMILES
- C(O)(=O)[C@@H]1CCCN1C
- CAS DataBase Reference
- 475-11-6
Safety
- WGK Germany
- 3
- HazardClass
- IRRITANT
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P233Keep container tightly closed.
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304IF INHALED:
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P340Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P362Take off contaminated clothing and wash before reuse.
P403Store in a well-ventilated place.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- M8021
- Product name
- N-Methyl-L-proline
- Packaging
- 500mg
- Price
- $489
- Updated
- 2023/06/20
- Product number
- M8021
- Product name
- N-Methyl-L-proline
- Packaging
- 1g
- Price
- $844
- Updated
- 2023/06/20
- Product number
- H63241
- Product name
- N-Methyl-L-proline, 98%
- Packaging
- 1g
- Price
- $347
- Updated
- 2021/12/16
- Product number
- H63241
- Product name
- N-Methyl-L-proline, 98%
- Packaging
- 250mg
- Price
- $117
- Updated
- 2021/12/16
- Product number
- 240080
- Product name
- N-Methyl-L-proline, 98%
- Packaging
- 250mg
- Price
- $206
- Updated
- 2021/12/16
N-Methyl-L-proline Chemical Properties,Usage,Production
Uses
N-Methyl-L-proline, is an aminoacid which is widely used in pharmaceuticals and food industry.
Definition
ChEBI: N-methylproline is an L-proline derivative obtained by replacement of the amino hydrogen by a methyl group. It has a role as a plant metabolite and a human metabolite. It is a L-proline derivative and a tertiary amino compound. It is a tautomer of a N-methylproline zwitterion.
Synthesis
L-Proline 86 (2.0 g, 17.4 mmol) was dissolved in methanol (20 mL) and to this solution was added 40% aqueous formaldehyde solution (1.4 mL, 19.1 mmol). This was followed by the addition of 10% palladiumon-charcoal catalyst (500 mg) and the resulting slurry was stirred in a hydrogen atmosphere overnight. The slurry was then filtered through a Celite pad to remove the catalyst. The pad was washed with methanol and the combined filtrates were concentrated under reduced pressure. The residue was taken up in ethanol-benzene (1:1, 100 mL) and concentrated a second time to provide a solid, which was recrystallized from methanol-diethyl ether. In this way N-Methyl-L-proline was isolated as fine needles (2.2 g, 98%). Mp 142-145 °C. [α]23 D -78.0° (c 2.0, MeOH). 1H NMR (300 MHz, D2O) δ 3.71-3.65 and 3.55-3.51 (2m, 1H), 3.00-2.91 (m, 1H), 2.74 (s, 3H), 2.34-2.28 (m, 1H), 1.99-1.78 (m, 3H). 13C NMR (75 MHz, CDCl3) δ 173.06, 70.18, 55.83, 40.26, 28.34, 22.37. IR (KBr disk) ν 3000-2800 (CH, saturated), 2675 and 2605 (ammonium ion), 1669 (CO2H), 1612 (CO2 -), 1468, 1401, 1354, 1327, 1234, 1183, 1112, 1056, 1025, 808, 775 cm-1. HRMS calcd for C6H11NO2 (M+) 129.0790, found 129.0784.
N-Methyl-L-proline Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from N-Methyl-L-proline manufacturers
- Product
- N-Methyl-L-proline 475-11-6
- Price
- US $1.00-22.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100000KG
- Release date
- 2024-08-02
- Product
- N-METHYL-L-PROLINE MONOHYDRATE 475-11-6
- Price
- US $100.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 5000kg/week
- Release date
- 2021-06-09
- Product
- N-Methyl-l-proline 475-11-6
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 97.8%
- Supply Ability
- 100 tons
- Release date
- 2022-02-18