N-Methyl-L-proline

ChemicalBook > CAS DataBase List > N-Methyl-L-proline

N-Methyl-L-proline

Product Name: N-Methyl-L-proline
CAS No.: 475-11-6
Chemical Name: N-Methyl-L-proline
Synonyms: N-METHYL-L-PROLINE;N-Methylproline;N-ME-PRO-OH;1-Methyl-L-proline;Hygric acid;N-ME-PROLINE;Hygrinic acid;N-Me-L-Pro-OH;PYRD(2)-OH H2O;H-MEPRO-OH H2O
CBNumber: CB1179181
Molecular Formula: C6H11NO2
Formula Weight: 129.16
MOL File: 475-11-6.mol

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N-Methyl-L-proline Property

Melting point:: 114-116 °C(lit.)
Boiling point:: 227℃
Density: 1.153
Flash point:: 91.1℃
refractive index: 1.5000
storage temp.: Sealed in dry,Store in freezer, under -20°C
solubility: Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
pka: 2.37±0.20(Predicted)
form: Powder
color: White to off-white
Water Solubility: Soluble in water and methanol(both 50 mg/ml-clear-colorless solution)
InChI: InChI=1S/C6H11NO2/c1-7-4-2-3-5(7)6(8)9/h5H,2-4H2,1H3,(H,8,9)/t5-/m0/s1
InChIKey: CWLQUGTUXBXTLF-YFKPBYRVSA-N
SMILES: C(O)(=O)[C@@H]1CCCN1C
CAS DataBase Reference: 475-11-6

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Safety

WGK Germany: 3
HazardClass: IRRITANT

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P233Keep container tightly closed.

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304IF INHALED:

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P340Remove victim to fresh air and keep at rest in a position comfortable for breathing.

P362Take off contaminated clothing and wash before reuse.

P403Store in a well-ventilated place.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: M8021
Product name: N-Methyl-L-proline
Packaging: 500mg
Price: $489
Updated: 2023/06/20

Sigma-Aldrich

Product number: M8021
Product name: N-Methyl-L-proline
Packaging: 1g
Price: $844
Updated: 2023/06/20

Alfa Aesar

Product number: H63241
Product name: N-Methyl-L-proline, 98%
Packaging: 1g
Price: $347
Updated: 2021/12/16

Alfa Aesar

Product number: H63241
Product name: N-Methyl-L-proline, 98%
Packaging: 250mg
Price: $117
Updated: 2021/12/16

Usbiological

Product number: 240080
Product name: N-Methyl-L-proline, 98%
Packaging: 250mg
Price: $206
Updated: 2021/12/16

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N-Methyl-L-proline Chemical Properties,Usage,Production

Uses

N-Methyl-L-proline, is an aminoacid which is widely used in pharmaceuticals and food industry.

Definition

ChEBI: N-methylproline is an L-proline derivative obtained by replacement of the amino hydrogen by a methyl group. It has a role as a plant metabolite and a human metabolite. It is a L-proline derivative and a tertiary amino compound. It is a tautomer of a N-methylproline zwitterion.

Synthesis

L-Proline 86 (2.0 g, 17.4 mmol) was dissolved in methanol (20 mL) and to this solution was added 40% aqueous formaldehyde solution (1.4 mL, 19.1 mmol). This was followed by the addition of 10% palladiumon-charcoal catalyst (500 mg) and the resulting slurry was stirred in a hydrogen atmosphere overnight. The slurry was then filtered through a Celite pad to remove the catalyst. The pad was washed with methanol and the combined filtrates were concentrated under reduced pressure. The residue was taken up in ethanol-benzene (1:1, 100 mL) and concentrated a second time to provide a solid, which was recrystallized from methanol-diethyl ether. In this way N-Methyl-L-proline was isolated as fine needles (2.2 g, 98%). Mp 142-145 °C. [α]23 D -78.0° (c 2.0, MeOH). 1H NMR (300 MHz, D2O) δ 3.71-3.65 and 3.55-3.51 (2m, 1H), 3.00-2.91 (m, 1H), 2.74 (s, 3H), 2.34-2.28 (m, 1H), 1.99-1.78 (m, 3H). 13C NMR (75 MHz, CDCl3) δ 173.06, 70.18, 55.83, 40.26, 28.34, 22.37. IR (KBr disk) ν 3000-2800 (CH, saturated), 2675 and 2605 (ammonium ion), 1669 (CO2H), 1612 (CO2 -), 1468, 1401, 1354, 1327, 1234, 1183, 1112, 1056, 1025, 808, 775 cm-1. HRMS calcd for C6H11NO2 (M+) 129.0790, found 129.0784.

N-Methyl-L-proline Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from N-Methyl-L-proline manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: N-Methyl-L-proline 475-11-6
Price: US $1.00-22.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100000KG
Release date: 2024-08-02

Hebei Mojin Biotechnology Co., Ltd

Product: N-METHYL-L-PROLINE MONOHYDRATE 475-11-6
Price: US $100.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 5000kg/week
Release date: 2021-06-09

Honest Joy Holdings Limited

Product: N-Methyl-l-proline 475-11-6
Price: US $0.00/KG
Min. Order: 1KG
Purity: 97.8%
Supply Ability: 100 tons
Release date: 2022-02-18

475-11-6, N-Methyl-L-prolineRelated Search:

N-METHYL-L-PROLINE MONOHYDRATE 98 N-Methyl-L-proline N-Cbz-Hydroxy-L-proline L-Alanyl-L-proline BOC-HYP(BZL)-OH BOC-L-Proline N-(2,4-DINITROPHENYL)-L-PROLINE Fmoc-Pro-OH GLYCYL-L-PROLINE 4-METHOXY-2-METHYLBENZOIC ACID (S)-4-METHYLENE-PYRROLIDINE-1,2-DICARBOXYLIC ACID 1-TERT-BUTYL ESTER L-Proline H-ALA-PRO-OME HCL Z-ALA-PRO-OH PHE-PRO H-PRO-PRO-OH HCL H-MET-PRO-OH H-VAL-PRO-OTBU HCL

N-ME-L-PROLINE HYDROCHLORIDE

N-ME-PROLINE

N-ME-PRO-OH

N-ME-PRO-OH HCL

N-METHYL-L-PROLINE

N-METHYL-L-PROLINE MONOHYDRATE

PYRD(2)-OH H2O

N-ALPHA-METHYL-L-PROLINE

N-ALPHA-METHYL-L-PROLINE HYDRATE

N-ALPHA-METHYL-L-PYRROLIDINE-2-CARBOXYLIC ACID HYDRATE

MEPYRD(2)-OH H2O

H-MEPRO-OH H2O

1-Methyl-L-proline

1-Methylproline

Hygric acid

N-Methylproline

(2S)-1-Methylpyrrolidine-2-carboxylic acid

(-)-Hygrinic acid

(2S)-1-Methyl-2-pyrrolidinecarboxylic acid

Hygrinic acid

tert-butyl N-[4-(aminomethyl)cyclohexyl]carbamate,hydrochloride

N-Me-L-Pro-OH

N-Methyl-L-proline98+%

N-METHYL-L-PROLINE MONOHYDRATE HCL

L-Proline, 1-methyl-

N-METHYL-L-PROLINE MONOHYDRATE USP/EP/BP

475-11-6

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Modified Amino Acids