2-FLUORO-3-HYDROXYPHENYLBORONIC ACID
- Product Name
- 2-FLUORO-3-HYDROXYPHENYLBORONIC ACID
- CAS No.
- 855230-60-3
- Chemical Name
- 2-FLUORO-3-HYDROXYPHENYLBORONIC ACID
- Synonyms
- (2-Fluoro-3-hydroxyphenyl);2-FLUORO-3-HYDROXYPHENYLBORONIC ACID;2-Fluoro-3-hydroxybenzeneboronic acid;2-Fluoro-3-hydroxybenzeneboronicacid96%;2-Fluoro-3-hydroxybenzeneboronic acid 96%;Boronic acid, B-(2-fluoro-3-hydroxyphenyl)-;(2-Fluoro-3-hydroxyphenyl)boronic acid(contains varying amounts of Anhydride)
- CBNumber
- CB4137409
- Molecular Formula
- C6H6BFO3
- Formula Weight
- 155.92
- MOL File
- 855230-60-3.mol
2-FLUORO-3-HYDROXYPHENYLBORONIC ACID Property
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- form
- solid
- color
- pink
Safety
- HS Code
- 2931900090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
N-Bromosuccinimide Price
- Product number
- F595323
- Product name
- 2-Fluoro-3-hydroxyphenylboronicacid
- Packaging
- 25mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- F595323
- Product name
- 2-Fluoro-3-hydroxyphenylboronicacid
- Packaging
- 250mg
- Price
- $130
- Updated
- 2021/12/16
- Product number
- CS-B1249
- Product name
- 2-Fluoro-3-hydroxyphenylboronicacid
- Purity
- 99.85%
- Packaging
- 1g
- Price
- $50
- Updated
- 2021/12/16
- Product number
- J98138
- Product name
- 2-Fluoro-3-hydroxyphenylboronicacid
- Packaging
- 1g
- Price
- $75
- Updated
- 2021/12/16
- Product number
- CS-B1249
- Product name
- 2-Fluoro-3-hydroxyphenylboronicacid
- Purity
- 99.85%
- Packaging
- 5g
- Price
- $147
- Updated
- 2021/12/16
2-FLUORO-3-HYDROXYPHENYLBORONIC ACID Chemical Properties,Usage,Production
Synthesis
352303-67-4
855230-60-3
General procedure for the synthesis of 2-fluoro-3-hydroxyphenylboronic acid from 2-fluoro-3-methoxyphenylboronic acid: 2-fluoro-3-methoxyphenylboronic acid (1.1 g, 6.5 mmol) was dissolved in 30 mL of dichloromethane and cooled to 5 °C under nitrogen protection. Under stirring conditions, 32 mL of a dichloromethane solution of boron tribromide (1 M, 32 mmol) was slowly added dropwise. After the dropwise addition, the reaction mixture was stirred at room temperature for 1 hour. Subsequently, the reaction mixture was slowly added dropwise to 50 mL of pre-cooled ethanol. An excess of solid sodium bicarbonate was added in batches to neutralize the reaction mixture under cooled conditions. After completion of neutralization, stirring was continued for 15 minutes, followed by filtration and the filtrate was evaporated and concentrated. The residue was dissolved in tetrahydrofuran, filtered again and the solvent evaporated to give 0.96 g (96% yield) of 2-fluoro-3-hydroxyphenylboronic acid. The product was characterized by 1H NMR (200 MHz, DMSO-d6): δ 9.53 (1H, s), 8.13 (2H, m), 6.91 (3H, m).
References
[1] Patent: EP2196465, 2010, A1. Location in patent: Page/Page column 30; 31
[2] Journal of Medicinal Chemistry, 2016, vol. 59, # 23, p. 10479 - 10497
[3] Patent: WO2006/5918, 2006, A1. Location in patent: Page/Page column 89
2-FLUORO-3-HYDROXYPHENYLBORONIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
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