mycotrienin II
- Product Name
- mycotrienin II
- CAS No.
- 82189-04-6
- Chemical Name
- mycotrienin II
- Synonyms
- mycotrienin II;T 23II, Mycotrienin II, T 23II;20,23-Didehydro-20,23-dideoxo-20,23-dihydroxyansatrienol A 11-[(R)-2-(cyclohexylcarbonylamino)propanoate];D-Alanine, N-(cyclohexylcarbonyl)-, (5R,6E,8E,10E,13S,14R,15R,16Z)-15,22,24-trihydroxy-5-methoxy-14,16-dimethyl-3-oxo-2-azabicyclo[18.3.1]tetracosa-1(24),6,8,10,16,20,22-heptaen-13-yl ester
- CBNumber
- CB41375521
- Molecular Formula
- C36H50N2O8
- Formula Weight
- 638.79
- MOL File
- 82189-04-6.mol
mycotrienin II Property
- storage temp.
- -20°C
- solubility
- Soluble in DMSO, DMF, Ethanol or Methanol
- form
- solid
- color
- Pale-yellow
- Stability:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO, DMF, ethanol, or methanol may be stored at -20°C for up to 3 months.
N-Bromosuccinimide Price
- Product number
- 21996
- Product name
- Ansatrienin B
- Purity
- ≥95%
- Packaging
- 1mg
- Price
- $353
- Updated
- 2024/03/01
- Product number
- 21996
- Product name
- Ansatrienin B
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $1365
- Updated
- 2024/03/01
- Product number
- A678305
- Product name
- AnsatrieninB
- Packaging
- 2.5mg
- Price
- $670
- Updated
- 2021/12/16
- Product number
- API0025351
- Product name
- ANSATRIENIN B
- Purity
- 95.00%
- Packaging
- 1MG
- Price
- $640.5
- Updated
- 2021/12/16
mycotrienin II Chemical Properties,Usage,Production
Description
Ansatrienin b (82189-04-6) represents a novel class of ansamycins.1 Inhibits osteoclastic bone resorption.2 Potentiates the activity of several clinically useful antitumor agents.3 Translation inhibitor which prevents ICAM-1 expression induced by pro-inflammatory cytokines.4
Uses
Ansatrienin B, also known as Mycotrienin II and Antibiotic T 23II, was isolated from a Streptomyces sp.. Closely related to the cytotrienins and trienomycins, it displays potent activity against tumour cell lines and inhibits osteoclastic bone resorption. Ansatrienin B also significantly potentiates the action of several clinical anti-cancer agents.
References
1) Sugita et al. (1982), Studies on mycotrienin antibiotics, a novel class of ansamycins. II. Structure elucidation and biosynthesis of mycotrienins I and II; J. Antibiot. (Tokyo), 35 1467 2) Feuerbach et al. (1995), Mycotrienins. A new class of potent inhibitors of osteoclastic bone resorption; J. Biol. Chem., 270 25949 3) Yamada et al. (2011), Mycotrienin II, a translation inhibitor that prevents ICAM-1 expression induced by pro-inflammatory cytokines; J. Antibiot. (Tokyo), 64 361
mycotrienin II Preparation Products And Raw materials
Raw materials
Preparation Products
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