ChemicalBook > CAS DataBase List > mycotrienin II

mycotrienin II

Product Name
mycotrienin II
CAS No.
82189-04-6
Chemical Name
mycotrienin II
Synonyms
mycotrienin II;T 23II, Mycotrienin II, T 23II;20,23-Didehydro-20,23-dideoxo-20,23-dihydroxyansatrienol A 11-[(R)-2-(cyclohexylcarbonylamino)propanoate];D-Alanine, N-(cyclohexylcarbonyl)-, (5R,6E,8E,10E,13S,14R,15R,16Z)-15,22,24-trihydroxy-5-methoxy-14,16-dimethyl-3-oxo-2-azabicyclo[18.3.1]tetracosa-1(24),6,8,10,16,20,22-heptaen-13-yl ester
CBNumber
CB41375521
Molecular Formula
C36H50N2O8
Formula Weight
638.79
MOL File
82189-04-6.mol
More
Less

mycotrienin II Property

storage temp. 
-20°C
solubility 
Soluble in DMSO, DMF, Ethanol or Methanol
form 
solid
color 
Pale-yellow
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO, DMF, ethanol, or methanol may be stored at -20°C for up to 3 months.
More
Less

Hazard and Precautionary Statements (GHS)

More
Less

N-Bromosuccinimide Price

Cayman Chemical
Product number
21996
Product name
Ansatrienin B
Purity
≥95%
Packaging
1mg
Price
$353
Updated
2024/03/01
Cayman Chemical
Product number
21996
Product name
Ansatrienin B
Purity
≥95%
Packaging
5mg
Price
$1365
Updated
2024/03/01
TRC
Product number
A678305
Product name
AnsatrieninB
Packaging
2.5mg
Price
$670
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0025351
Product name
ANSATRIENIN B
Purity
95.00%
Packaging
1MG
Price
$640.5
Updated
2021/12/16
More
Less

mycotrienin II Chemical Properties,Usage,Production

Description

Ansatrienin b (82189-04-6) represents a novel class of ansamycins.1 Inhibits osteoclastic bone resorption.2 Potentiates the activity of several clinically useful antitumor agents.3 Translation inhibitor which prevents ICAM-1 expression induced by pro-inflammatory cytokines.4

Uses

Ansatrienin B, also known as Mycotrienin II and Antibiotic T 23II, was isolated from a Streptomyces sp.. Closely related to the cytotrienins and trienomycins, it displays potent activity against tumour cell lines and inhibits osteoclastic bone resorption. Ansatrienin B also significantly potentiates the action of several clinical anti-cancer agents.

in vivo

Ansatrienin B (intraperitoneal injection; once daily; 6 days) is against P-388 -injected mouse tumor growth. The LD50 value in mice of MTN-II is 80 mg/kg in CDF1 male mice[2].

References

[1] M SUGITA. Studies on mycotrienin antibiotics, a novel class of ansamycins. II. Structure elucidation and biosynthesis of mycotrienins I and II.[J]. Journal of Antibiotics, 1982, 35 11: 1467-1473. DOI:10.7164/antibiotics.35.1467
[2] D FEUERBACH. Mycotrienins. A new class of potent inhibitors of osteoclastic bone resorption.[J]. The Journal of Biological Chemistry, 1995, 270 43: 25949-25955. DOI:10.1074/jbc.270.43.25949
[3] YURIKO YAMADA. Mycotrienin II, a translation inhibitor that prevents ICAM-1 expression induced by pro-inflammatory cytokines[J]. Journal of Antibiotics, 2011, 64 5: 361-366. DOI:10.1038/ja.2011.23

mycotrienin II Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

mycotrienin II Suppliers

China 20 United Kingdom 1 United States 5 Global 26
Lynnchem
Tel
86-(0)29-85992781 17792393971
Email
info@lynnchem.com
Country
China
ProdList
4587
Advantage
58
Shanghai Hongye Biotechnology Co. Ltd
Tel
400-9205774
Email
sales@glpbio.cn
Country
China
ProdList
6777
Advantage
58
Shenzhen Polymeri Biochemical Technology Co., Ltd.
Tel
+86-400-002-6226 +86-13028896684;
Email
sales@rrkchem.com
Country
China
ProdList
57422
Advantage
58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
Tel
18818260767
Fax
QQ 3610331285
Email
sales@chemegen.com
Country
China
ProdList
11218
Advantage
58
Meng Cheng Technology (Shanghai) Co., LTD
Tel
400-820-6829
Email
sales@mitachieve.com
Country
China
ProdList
8860
Advantage
58
Zhejiang Huida Biotech Co., LTD
Tel
0571-89903882 18679456698
Email
mingxinzhu@huidabiotech.com
Country
China
ProdList
2975
Advantage
58
Energy Chemical
Tel
021-58432009 400-005-6266
Fax
021-58436166
Email
marketing@energy-chemical.com
Country
China
ProdList
44918
Advantage
58
Zhejiang Huida Biotech Co., LTD
Tel
0571-0571-89903882 15990081639
Email
sunshixuan@huidabiotech.com
Country
China
ProdList
3705
Advantage
58
TargetMol Chemicals Inc.
Tel
4008200310
Email
marketing@tsbiochem.com
Country
China
ProdList
24961
Advantage
58
Shanghai Saikerui Biotechnology Co. , Ltd.
Tel
021-58000709 15900491054
Email
info@scrbio.com
Country
China
ProdList
9881
Advantage
58
Shanghai Yifei Biotechnology Co. , Ltd.
Tel
021-65675885 18964387627
Email
customer_service@efebio.com
Country
China
ProdList
11973
Advantage
58
Nanjing Shizhou Biology Technology Co.,Ltd
Tel
025-85560043 15850508050
Fax
025-85563444
Email
cindy.huang@synzest.com
Country
China
ProdList
12000
Advantage
58
RD International Technology Co., Limited
Tel
18024082417
Email
market@ubiochem.com
Country
China
ProdList
9835
Advantage
58
Shanghai Weiyite Biotechnology Co., Ltd
Tel
15317051735
Email
zhaojing@wytsci.com
Country
China
ProdList
9980
Advantage
58
Cayman Chemical Company
Tel
800-364-9897
Email
sales@caymanchem.com
Country
China
ProdList
6838
Advantage
58
Biosynth Biological Technology (Suzhou) Co Ltd
Tel
51288865780
Email
sales@biosynth.com
Country
China
ProdList
6051
Advantage
58
Adooq Bioscience LLC
Tel
400-025-6535
Email
sales@adooq.cn
Country
China
ProdList
6215
Advantage
58
Santa Cruz Biotechnology Inc
Tel
021-60936350
Email
scbt@scbt.com
Country
China
ProdList
6594
Advantage
58
Absin Bioscience Inc.
Tel
--
Fax
--
Email
chenjw@absin.cn
Country
CHINA
ProdList
6208
Advantage
58
Shanghai Hao Zhun Biological Technology Co., Ltd.
Tel
--
Fax
--
Email
info@zzsrm.com
Country
CHINA
ProdList
6650
Advantage
58

82189-04-6, mycotrienin IIRelated Search:

Zoledronic acid SALUBRINAL CHIR-99021 SU 4312 Ansatrienol A, 20,23-didehydro-20,23-dideoxo-20,23-dihydroxy- mycotrienin II hexahydrohippurate trienomycin A

  • mycotrienin II
  • 20,23-Didehydro-20,23-dideoxo-20,23-dihydroxyansatrienol A 11-[(R)-2-(cyclohexylcarbonylamino)propanoate]
  • T 23II, Mycotrienin II, T 23II
  • D-Alanine, N-(cyclohexylcarbonyl)-, (5R,6E,8E,10E,13S,14R,15R,16Z)-15,22,24-trihydroxy-5-methoxy-14,16-dimethyl-3-oxo-2-azabicyclo[18.3.1]tetracosa-1(24),6,8,10,16,20,22-heptaen-13-yl ester
  • 82189-04-6