Xanomeline
- Product Name
- Xanomeline
- CAS No.
- 131986-45-3
- Chemical Name
- Xanomeline
- Synonyms
- XANOMELINE;Memcor;Lomeron;LY-246708;NNC-11-0232;3-(Hexyloxy);Xanomeline(LY-246708);Xanomeline L-tartrate hydrate;Xanomeline L-tartrate hydrate >=98% (HPLC);-4-(1-methyl-1,2,5,6-tetrahydropyridin-3-yl)
- CBNumber
- CB4144966
- Molecular Formula
- C14H23N3OS
- Formula Weight
- 281.42
- MOL File
- 131986-45-3.mol
Xanomeline Property
- Boiling point:
- 397.0±42.0 °C(Predicted)
- Density
- 1.101±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,2-8°C
- solubility
- H2O: soluble10mg/mL, clear (warmed)
- form
- powder
- pka
- 7.34±0.40(Predicted)
- color
- off-white
- InChIKey
- JOLJIIDDOBNFHW-UHFFFAOYSA-N
Safety
- WGK Germany
- 3
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H301Toxic if swalloed
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P330Rinse mouth.
N-Bromosuccinimide Price
- Product number
- X2754
- Product name
- Xanomeline L-tartrate hydrate
- Purity
- ≥98% (HPLC)
- Packaging
- 25mg
- Price
- $905
- Updated
- 2022/05/15
- Product number
- H298183
- Product name
- 3-(Hexyloxy)-4-(1-Methyl-1,2,5,6-Tetrahydropyridin-3-Yl)-1,2,5-Thiadiazole
- Packaging
- 25mg
- Price
- $220
- Updated
- 2021/12/16
- Product number
- 097008
- Product name
- 3-(Hexyloxy)-4-(1-methyl-1,2,5,6-tetrahydropyridin-3-yl)-1,2,5-thiadiazole
- Purity
- 95+%
- Packaging
- 250mg
- Price
- $695
- Updated
- 2021/12/16
- Product number
- 097008
- Product name
- 3-(Hexyloxy)-4-(1-methyl-1,2,5,6-tetrahydropyridin-3-yl)-1,2,5-thiadiazole
- Purity
- 95+%
- Packaging
- 500mg
- Price
- $1073
- Updated
- 2021/12/16
- Product number
- API0008412
- Product name
- XANOMELINE L-TARTRATE HYDRATE
- Purity
- 95.00%
- Packaging
- 25MG
- Price
- $1294.01
- Updated
- 2021/12/16
Xanomeline Chemical Properties,Usage,Production
Description
Xanomeline is used as a potent and selective muscarinic type 1 and type 4 (M1/M4) receptor agonist to increase neuronal excitability. Xanomeline is used in studies of neurological disorders such as Alzheimer's disease and schizophrenia. However, development of the drug was halted due to severe cholinergic adverse effects. Currently, xanomeline-trospium (KarXT) (a peripheral cholinergic antagonist) has been explored for the treatment of schizophrenia and a New Drug Application has been filed with the FDA, with a decision on whether it will be approved or not expected on 26 September 2024.
Uses
Alzheimer’s disease treatment (cholinergic agonist).
Definition
ChEBI: Xanomeline is a member of thiadiazoles and a tetrahydropyridine. It has a role as a muscarinic agonist and a serotonergic agonist.
Mechanism of action
Xanomeline's mechanism of action is is to rebalance key neurotransmitter circuits, including acetylcholine, dopamine and glutamate, which are disrupted in schizophrenia and related disorders.
Xanomeline Preparation Products And Raw materials
Raw materials
Preparation Products
Xanomeline Suppliers
View Lastest Price from Xanomeline manufacturers
- Product
- 5-(4-HEXYLOXY-[1,2,5]THIADIAZOL-3-YL)-1-METHYL-1,2,3,6-TETRAHYDRO-PYRIDINE 131986-45-3
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.9%
- Supply Ability
- 100 Tons Min
- Release date
- 2021-05-28
- Product
- 5-(4-HEXYLOXY-[1,2,5]THIADIAZOL-3-YL)-1-METHYL-1,2,3,6-TETRAHYDRO-PYRIDINE 131986-45-3
- Price
- US $9.80/KG
- Min. Order
- 1g
- Purity
- ≥99%
- Supply Ability
- 100kg
- Release date
- 2020-01-13