Xanomeline

Product Name: Xanomeline
CAS No.: 131986-45-3
Chemical Name: Xanomeline
Synonyms: XANOMELINE;Memcor;Lomeron;LY-246708;NNC-11-0232;3-(Hexyloxy);Xanomeline(LY-246708);Xanomeline L-tartrate hydrate;Xanomeline L-tartrate hydrate >=98% (HPLC);-4-(1-methyl-1,2,5,6-tetrahydropyridin-3-yl)
CBNumber: CB4144966
Molecular Formula: C14H23N3OS
Formula Weight: 281.42
MOL File: 131986-45-3.mol

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Xanomeline Property

Boiling point:: 397.0±42.0 °C(Predicted)
Density: 1.101±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,2-8°C
solubility: H2O: soluble10mg/mL, clear (warmed)
form: powder
pka: 7.34±0.40(Predicted)
color: off-white
InChIKey: JOLJIIDDOBNFHW-UHFFFAOYSA-N

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: X2754
Product name: Xanomeline L-tartrate hydrate
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $905
Updated: 2022/05/15

TRC

Product number: H298183
Product name: 3-(Hexyloxy)-4-(1-Methyl-1,2,5,6-Tetrahydropyridin-3-Yl)-1,2,5-Thiadiazole
Packaging: 25mg
Price: $220
Updated: 2021/12/16

Matrix Scientific

Product number: 097008
Product name: 3-(Hexyloxy)-4-(1-methyl-1,2,5,6-tetrahydropyridin-3-yl)-1,2,5-thiadiazole
Purity: 95+%
Packaging: 250mg
Price: $695
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0008412
Product name: XANOMELINE L-TARTRATE HYDRATE
Purity: 95.00%
Packaging: 5MG
Price: $767.38
Updated: 2021/12/16

Matrix Scientific

Product number: 097008
Product name: 3-(Hexyloxy)-4-(1-methyl-1,2,5,6-tetrahydropyridin-3-yl)-1,2,5-thiadiazole
Purity: 95+%
Packaging: 500mg
Price: $1073
Updated: 2021/12/16

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Xanomeline Chemical Properties,Usage,Production

Description

Xanomeline is used as a potent and selective muscarinic type 1 and type 4 (M1/M4) receptor agonist to increase neuronal excitability. Xanomeline is used in studies of neurological disorders such as Alzheimer's disease and schizophrenia. However, development of the drug was halted due to severe cholinergic adverse effects. Currently, xanomeline-trospium (KarXT) (a peripheral cholinergic antagonist) has been explored for the treatment of schizophrenia and a New Drug Application has been filed with the FDA, with a decision on whether it will be approved or not expected on 26 September 2024.

Uses

Alzheimer’s disease treatment (cholinergic agonist).

Definition

ChEBI: Xanomeline is a member of thiadiazoles and a tetrahydropyridine. It has a role as a muscarinic agonist and a serotonergic agonist.

Mechanism of action

Xanomeline's mechanism of action is is to rebalance key neurotransmitter circuits, including acetylcholine, dopamine and glutamate, which are disrupted in schizophrenia and related disorders.

Xanomeline Preparation Products And Raw materials

Raw materials

3-PYRIDYLACETONITRILE Sodium borohydride Sodium hexylate Iodomethane Praseodymium(III) nitrate hexahydrate Formamide

Preparation Products

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Xanomeline Suppliers

China 77 Germany 1 India 3 Sweden 1 United Kingdom 1 United States 11 Global 94

LGM Pharma

Tel: 1-(800)-881-8210
Fax: 615-250-9817
Email: inquiries@lgmpharma.com
Country: United States
ProdList: 2123
Advantage: 70

TargetMol Chemicals Inc.

Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Country: United States
ProdList: 32161
Advantage: 58

Alchem Pharmtech,Inc.

Tel: 8485655694
Email: sales@alchempharmtech.com
Country: United States
ProdList: 63687
Advantage: 58

Protheragen-ING

Tel: +16313385890
Email: info@protheragen-ing.com
Country: United States
ProdList: 3868
Advantage: 58

Combi-Blocks Inc.

Tel: --
Fax: --
Email: sales@combi-blocks.com
Country: United States
ProdList: 6618
Advantage: 69

Riedel-de Haen AG

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Fax: --
Country: United States
ProdList: 6773
Advantage: 87

Matrix Scientific

Tel: --
Fax: --
Email: sales@matrixscientific.com
Country: United States
ProdList: 6632
Advantage: 80

Waterstone Technology, LLC

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Email: sales@waterstonetech.com
Country: United States
ProdList: 6786
Advantage: 30

3B Scientific Corporation

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Email: sales@3bsc.com
Country: United States
ProdList: 6718
Advantage: 47

AK Scientific, Inc.

Tel: --
Fax: --
Email: sales@aksci.com
Country: United States
ProdList: 6347
Advantage: 65

Fine Chem Trading LTD

Tel: --
Fax: --
Email: chemfinder@chemfinder.co.uk
Country: United States
ProdList: 1609
Advantage: 64

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View Lastest Price from Xanomeline manufacturers

Shaanxi Dideu New Materials Co. Ltd

Product: Xanomeline 131986-45-3
Price: US $0.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 5000KGS
Release date: 2024-11-12

Dideu Industries Group Limited

Product: 5-(4-HEXYLOXY-[1,2,5]THIADIAZOL-3-YL)-1-METHYL-1,2,3,6-TETRAHYDRO-PYRIDINE 131986-45-3
Price: US $1.10/g
Min. Order: 1g
Purity: 99.9%
Supply Ability: 100 Tons Min
Release date: 2021-05-28

Career Henan Chemical Co

Product: 5-(4-HEXYLOXY-[1,2,5]THIADIAZOL-3-YL)-1-METHYL-1,2,3,6-TETRAHYDRO-PYRIDINE 131986-45-3
Price: US $9.80/KG
Min. Order: 1g
Purity: ≥99%
Supply Ability: 100kg
Release date: 2020-01-13

131986-45-3, XanomelineRelated Search:

(-)-Huperzine A Donepezil SABCOMELINE 1,2,5-THIADIAZOL-3-OL 5-(4-HEXYLOXY-[1,2,5]THIADIAZOL-3-YL)-1-METHYL-1,2,3,6-TETRAHYDRO-PYRIDINE

3-[4-(Hexy loxy)-1，2，5-thiadiazol-3-y1]-1，2，5，6-tetrahydro-1-methylpyridine

5-(4-HEXYLOXY-[1,2,5]THIADIAZOL-3-YL)-1-METHYL-1,2,3,6-TETRAHYDRO-PYRIDINE

XANOMELINE

Lomeron

LY-246708

Memcor

NNC-11-0232

3-(Hexyloxy)-4-(1-methyl-1,2,5,6-tetrahydropyridin-3-yl)-1,2,5-thiadiazole

Xanomeline L-tartrate hydrate

3-(Hexyloxy)

-4-(1-methyl-1,2,5,6-tetrahydropyridin-3-yl)

3-Hexoxy-4-(1-methyl-3,6-dihydro-2H-pyridin-5-yl)-1,2,5-thiadiazole

Pyridine, 3-[4-(hexyloxy)-1,2,5-thiadiazol-3-yl]-1,2,5,6-tetrahydro-1-methyl-

Xanomeline L-tartrate hydrate >=98% (HPLC)

5-(4-HEXYLOXY-[1,2,5]THIADIAZOL-3-YL)-1-METHYL-1,2,3,6-TETRAHYDRO-PYRIDINE USP/EP/BP

Xanomeline(LY-246708)

3-(Hexyloxy)-4-(1-methyl-1,2,5,6-tetrahydro-3-pyridyl)-1,2,5-thiadiazole

131986-45-3

C14H23N3OS

API