5-chloro-3-methylsulfanyl-2,4,9-triazabicyclo[4.3.0]nona-2,4,7,10-tetraene
- Product Name
- 5-chloro-3-methylsulfanyl-2,4,9-triazabicyclo[4.3.0]nona-2,4,7,10-tetraene
- CAS No.
- 57564-94-0
- Chemical Name
- 5-chloro-3-methylsulfanyl-2,4,9-triazabicyclo[4.3.0]nona-2,4,7,10-tetraene
- Synonyms
- NSC 70903;4-chloro-2-(Methylthio)-7H-pyrrolo[2;4-chloro-7H-pyrrolo[2,3-d]pyrimidin-5-amine;4-Chloro-2-methylthiopyrrolo[2,3-d]pyrimidine;2-(Methylthio)-4-chloropyrrolo<2,3-d>pyriMidine;4-Chloro-2-(Methylthio)-7H-pyrrolo[2,3-D]pyriMidin;7H-Pyrrolo[2,3-D]pyrimidine, 4-chloro-2-(methylthio)-;4-Chloro-2-methylsulfanyl-7H-pyrrolo[2,3-d]pyrimidine;Inchi=1/C7H6cln3S/C1-12-7-10-5(8)4-2-3-9-6(4)11-7/H2-3H,1H3,(H,9,10,11;5-chloro-3-methylsulfanyl-2,4,9-triazabicyclo[4.3.0]no-2,4,7,10-tetraene
- CBNumber
- CB41457962
- Molecular Formula
- C7H6ClN3S
- Formula Weight
- 199.66
- MOL File
- 57564-94-0.mol
5-chloro-3-methylsulfanyl-2,4,9-triazabicyclo[4.3.0]nona-2,4,7,10-tetraene Property
- Boiling point:
- 342.1±52.0 °C(Predicted)
- Density
- 1.59
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- pka
- 10.01±0.20(Predicted)
- Appearance
- Off-white to light yellow Solid
- InChI
- InChI=1S/C7H6ClN3S/c1-12-7-10-5(8)4-2-3-9-6(4)11-7/h2-3H,1H3,(H,9,10,11)
- InChIKey
- WEGGBXZHIWVHOI-UHFFFAOYSA-N
- SMILES
- C1(SC)=NC(Cl)=C2C=CNC2=N1
N-Bromosuccinimide Price
- Product number
- JRD0387
- Product name
- 4-Chloro-2-(methylthio)-7H-pyrrolo[2,3-d]pyrimidine
- Purity
- Aldrich
- Packaging
- 1g
- Price
- $463
- Updated
- 2023/01/07
- Product number
- C994603
- Product name
- 4-Chloro-2-(methylthio)-7H-pyrrolo[2,3-d]pyrimidine
- Packaging
- 10mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- BP-20050
- Product name
- 4-chloro-2-(methylthio)-7H-pyrrolo[2,3-d]pyrimidine
- Purity
- 97%
- Packaging
- 250mg
- Price
- $180
- Updated
- 2021/12/16
- Product number
- BP-20050
- Product name
- 4-chloro-2-(methylthio)-7H-pyrrolo[2,3-d]pyrimidine
- Purity
- 97%
- Packaging
- 1g
- Price
- $335
- Updated
- 2021/12/16
- Product number
- 7H66-5-95
- Product name
- 4-Chloro-2-(methylthio)-7H-pyrrolo[2,3-d]pyrimidine
- Packaging
- 250mg
- Price
- $416
- Updated
- 2021/12/16
5-chloro-3-methylsulfanyl-2,4,9-triazabicyclo[4.3.0]nona-2,4,7,10-tetraene Chemical Properties,Usage,Production
Synthesis
67831-83-8
57564-94-0
General procedure for the synthesis of 4-chloro-2-(methylthio)-7H-pyrrolo[2,3-d]pyrimidines from 2-methylthio-4-hydroxy-7H-pyrrolo[2,3-d]pyrimidines: triclosan (5 mL, 53.7 mmol) and triethylamine (0.2 mL, 1.43 mmol) were added to 2-methylthio-7H-pyrrolo[2,3-d]pyrimidin-4-yl alcohol (0.10 g, 0.55 mmol). The reaction mixture was heated to reflux at 130 °C for 4 h and subsequently cooled to room temperature. Excess trichlorophosphate was removed by distillation under reduced pressure. Ice water was carefully added to the residue and the suspension was extracted with ether (3 x 20 mL). The organic phases were combined, washed with distilled water (10 mL), dried over anhydrous magnesium sulfate, filtered and concentrated under reduced pressure. The crude product was purified by column chromatography (Florisil, 100-200 mesh), using diethyl ether as eluent, to give the pure 4-chloro-2-methylthio-7H-pyrrolo[2,3-d]pyrimidine in 77% yield (literature value 43%). Melting point: 207-209°C. 1H NMR (CDCl3): δ 2.67 (s, 3H, SCH3), 6.56-6.59 (m, 1H, H-5), 7.21-7.23 (m, 1H, H-6). IR (KBr) cm-1: 3412 (NH), 3122 (CH), 1614 (C=C). Mass Spectrometry (MS): m/z [M+1]+ 201. Calculated values for elemental analysis (C7H6N3ClS): C 42.11, H 3.03, N 21.05, S 16.06; measured values: C 42.29, H 3.38, N 21.14, S 16.36.
References
[1] Bioorganic and Medicinal Chemistry, 2012, vol. 20, # 22, p. 6770 - 6789
[2] European Journal of Medicinal Chemistry, 2017, vol. 127, p. 369 - 378
5-chloro-3-methylsulfanyl-2,4,9-triazabicyclo[4.3.0]nona-2,4,7,10-tetraene Preparation Products And Raw materials
Raw materials
Preparation Products
5-chloro-3-methylsulfanyl-2,4,9-triazabicyclo[4.3.0]nona-2,4,7,10-tetraene Suppliers
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- Country
- Switzerland
- ProdList
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View Lastest Price from 5-chloro-3-methylsulfanyl-2,4,9-triazabicyclo[4.3.0]nona-2,4,7,10-tetraene manufacturers
- Product
- 5-chloro-3-methylsulfanyl-2,4,9-triazabicyclo[4.3.0]nona-2,4,7,10-tetraene 57564-94-0
- Price
- US $9.80/KG
- Min. Order
- 1g
- Purity
- ≥99%
- Supply Ability
- 100kg
- Release date
- 2020-01-10