4-CHLORO-1,3-DIHYDRO-INDOL-2-ONE
- Product Name
- 4-CHLORO-1,3-DIHYDRO-INDOL-2-ONE
- CAS No.
- 20870-77-3
- Chemical Name
- 4-CHLORO-1,3-DIHYDRO-INDOL-2-ONE
- Synonyms
- AKOS 207-07;4-CHLOROOXINDOLE;4-CHLORO-2-OXINDOLE;4-Chloro-2-oxoindole;4-chloroindolin-2-one;4-Chloroindoline-2-one;4-Chloro-1H-indol-2(3H)-one;4-CHLORO-1,3-DIHYDRO-INDOL-2-ONE;4-CHLORO-1,3-DIHYDRO-2H-INDOL-2-ONE;4-chloro-2,3-dihydro-1H-indol-2-one
- CBNumber
- CB4740285
- Molecular Formula
- C8H6ClNO
- Formula Weight
- 167.59
- MOL File
- 20870-77-3.mol
4-CHLORO-1,3-DIHYDRO-INDOL-2-ONE Property
- Melting point:
- 206-208°
- Boiling point:
- 340.3±42.0 °C(Predicted)
- Density
- 1.362±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- form
- powder
- pka
- 13.27±0.20(Predicted)
- color
- yellow
- InChI
- InChI=1S/C8H6ClNO/c9-6-2-1-3-7-5(6)4-8(11)10-7/h1-3H,4H2,(H,10,11)
- InChIKey
- XNSPDJAXCBZCRV-UHFFFAOYSA-N
- SMILES
- N1C2=C(C(Cl)=CC=C2)CC1=O
- CAS DataBase Reference
- 20870-77-3(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi
- HazardClass
- IRRITANT
- HS Code
- 2933790090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- C380803
- Product name
- 4-Chloroindolin-2-one
- Packaging
- 100mg
- Price
- $75
- Updated
- 2021/12/16
- Product number
- 044887
- Product name
- 4-Chloro-1,3-dihydro-2H-indol-2-one
- Purity
- 95+%
- Packaging
- 1g
- Price
- $37
- Updated
- 2021/12/16
- Product number
- 4H48-5-X9
- Product name
- 4-Chloro-2-oxindole
- Packaging
- 1g
- Price
- $42
- Updated
- 2021/12/16
- Product number
- 4H48-5-X9
- Product name
- 4-Chloro-2-oxindole
- Packaging
- 5G
- Price
- $167
- Updated
- 2021/12/16
- Product number
- W4375
- Product name
- 4-Chloroindolin-2-one
- Packaging
- 1g
- Price
- $93
- Updated
- 2021/12/16
4-CHLORO-1,3-DIHYDRO-INDOL-2-ONE Chemical Properties,Usage,Production
Synthesis
6344-05-4
20870-77-3
The general procedure for the synthesis of 4-chloro-2-oxoindole (4-chloroindolone) from 4-chloroindoline-2,3-dione was as follows: titanium tetrachloride (TiCl4) (0.7 mL, 6 mmol) was slowly added to a stirring suspension of zinc powder (0.78 g, 12 mmol) in freshly distilled anhydrous THF (15 mL) at room temperature and under dry nitrogen atmosphere. After addition, the mixture was refluxed for 2 hours. After the formed suspension of low-valent titanium reagent was cooled, a THF (10 mL) solution of indigo red or its derivative (2 mmol) was added dropwise. The reaction mixture was stirred at room temperature for about 5 min under nitrogen protection. After confirming the completion of the reaction by thin layer chromatography (TLC) analysis, the reaction was quenched with 3% hydrochloric acid (15 mL) and subsequently extracted with chloroform (3 x 50 mL). The organic phases were combined, washed with water (3 x 50 mL) and dried over anhydrous sodium sulfate. After concentration of the solvent under reduced pressure, the crude product was purified by column chromatography (petroleum ether/ethyl acetate = 5:1) to afford the target compound 4-chloro-2-oxindole (4-chloroindolone).
References
[1] Tetrahedron Letters, 2014, vol. 55, # 14, p. 2238 - 2242
4-CHLORO-1,3-DIHYDRO-INDOL-2-ONE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-CHLORO-1,3-DIHYDRO-INDOL-2-ONE manufacturers
- Product
- 4-Chloro-2-oxindole 4-Chloro-1,3-dihydro-indol-2-one in stock Factory 20870-77-3
- Price
- US $1.00/kg
- Min. Order
- 1kg
- Purity
- High quality purified Factory in China
- Supply Ability
- Top 3 production capacity Factory
- Release date
- 2019-04-03
- Product
- 4-CHLORO-1,3-DIHYDRO-INDOL-2-ONE 20870-77-3
- Price
- US $5.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 100KG
- Release date
- 2020-01-12