ChemicalBook > CAS DataBase List > 4-CHLORO-1,3-DIHYDRO-INDOL-2-ONE

4-CHLORO-1,3-DIHYDRO-INDOL-2-ONE

Product Name: 4-CHLORO-1,3-DIHYDRO-INDOL-2-ONE
CAS No.: 20870-77-3
Chemical Name: 4-CHLORO-1,3-DIHYDRO-INDOL-2-ONE
Synonyms: AKOS 207-07;4-CHLOROOXINDOLE;4-CHLORO-2-OXINDOLE;4-Chloro-2-oxoindole;4-chloroindolin-2-one;4-Chloroindoline-2-one;4-Chloro-1H-indol-2(3H)-one;4-CHLORO-1,3-DIHYDRO-INDOL-2-ONE;4-CHLORO-1,3-DIHYDRO-2H-INDOL-2-ONE;4-chloro-2,3-dihydro-1H-indol-2-one
CBNumber: CB4740285
Molecular Formula: C8H6ClNO
Formula Weight: 167.59
MOL File: 20870-77-3.mol

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4-CHLORO-1,3-DIHYDRO-INDOL-2-ONE Property

Melting point:: 206-208°
Boiling point:: 340.3±42.0 °C(Predicted)
Density: 1.362±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
form: powder
pka: 13.27±0.20(Predicted)
color: yellow
InChI: InChI=1S/C8H6ClNO/c9-6-2-1-3-7-5(6)4-8(11)10-7/h1-3H,4H2,(H,10,11)
InChIKey: XNSPDJAXCBZCRV-UHFFFAOYSA-N
SMILES: N1C2=C(C(Cl)=CC=C2)CC1=O
CAS DataBase Reference: 20870-77-3(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
HazardClass: IRRITANT
HS Code: 2933790090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: C380803
Product name: 4-Chloroindolin-2-one
Packaging: 100mg
Price: $75
Updated: 2021/12/16

Matrix Scientific

Product number: 044887
Product name: 4-Chloro-1,3-dihydro-2H-indol-2-one
Purity: 95+%
Packaging: 1g
Price: $37
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H48-5-X9
Product name: 4-Chloro-2-oxindole
Packaging: 1g
Price: $42
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H48-5-X9
Product name: 4-Chloro-2-oxindole
Packaging: 5G
Price: $167
Updated: 2021/12/16

AK Scientific

Product number: W4375
Product name: 4-Chloroindolin-2-one
Packaging: 1g
Price: $93
Updated: 2021/12/16

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4-CHLORO-1,3-DIHYDRO-INDOL-2-ONE Chemical Properties,Usage,Production

Synthesis

6344-05-4

20870-77-3

The general procedure for the synthesis of 4-chloro-2-oxoindole (4-chloroindolone) from 4-chloroindoline-2,3-dione was as follows: titanium tetrachloride (TiCl4) (0.7 mL, 6 mmol) was slowly added to a stirring suspension of zinc powder (0.78 g, 12 mmol) in freshly distilled anhydrous THF (15 mL) at room temperature and under dry nitrogen atmosphere. After addition, the mixture was refluxed for 2 hours. After the formed suspension of low-valent titanium reagent was cooled, a THF (10 mL) solution of indigo red or its derivative (2 mmol) was added dropwise. The reaction mixture was stirred at room temperature for about 5 min under nitrogen protection. After confirming the completion of the reaction by thin layer chromatography (TLC) analysis, the reaction was quenched with 3% hydrochloric acid (15 mL) and subsequently extracted with chloroform (3 x 50 mL). The organic phases were combined, washed with water (3 x 50 mL) and dried over anhydrous sodium sulfate. After concentration of the solvent under reduced pressure, the crude product was purified by column chromatography (petroleum ether/ethyl acetate = 5:1) to afford the target compound 4-chloro-2-oxindole (4-chloroindolone).

References

[1] Tetrahedron Letters, 2014, vol. 55, # 14, p. 2238 - 2242

4-CHLORO-1,3-DIHYDRO-INDOL-2-ONE Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 4-CHLORO-1,3-DIHYDRO-INDOL-2-ONE manufacturers

Chemwill Asia Co.,Ltd.

Product: 4-Chloro-2-oxindole 4-Chloro-1,3-dihydro-indol-2-one in stock Factory 20870-77-3
Price: US $1.00/kg
Min. Order: 1kg
Purity: High quality purified Factory in China
Supply Ability: Top 3 production capacity Factory
Release date: 2019-04-03

Career Henan Chemical Co

Product: 4-CHLORO-1,3-DIHYDRO-INDOL-2-ONE 20870-77-3
Price: US $5.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 100KG
Release date: 2020-01-12

20870-77-3, 4-CHLORO-1,3-DIHYDRO-INDOL-2-ONERelated Search:

4-CHLORO-1,3-DIHYDRO-INDOL-2-ONE 4-CHLOROISATIN 4,6-DICHLORO-1H-INDOLE-2,3-DIONE 5-CHLORO-1,3-DIHYDRO-INDOL-2-ONE 4,7-Dichloroisatin 4-Chloro-7-methylisatin 6-CHLORO-1,3-DIHYDRO-INDOL-2-ONE Oxindole 4-Chloroindoline 4,5-DICHLORO-1H-INDOLE-2,3-DIONE 4-CHLORO-5-METHYLISATIN 4-CHLORO-7-METHOXY ISATIN 1-ACETYL-4,6-DICHLORO-1H-INDOLE-2,3-DIONE 4,5,7-trichloro-1H-indole-2,3-dione 3,3-DIBROMO-6-CHLORO-1,3-DIHYDRO-INDOL-2-ONE 4-CHLORO-5-ETHYLISATIN 4-CHLORO-3-(4-HYDROXY-BENZYLIDENE)-1,3-DIHYDRO-INDOL-2-ONE BUTTPARK 80\07-01

4-chloro-2,3-dihydro-1H-indol-2-one

4-Chloro-2-oxindole 4-Chloro-1,3-dihydro-indol-2-one in stock Factory

4-CHLOROOXINDOLE

4-CHLORO-2-OXINDOLE

4-CHLORO-1,3-DIHYDRO-2H-INDOL-2-ONE

4-CHLORO-1,3-DIHYDRO-INDOL-2-ONE

AKOS 207-07

4-Chloro-2-oxoindole

4-Chloro-1H-indol-2(3H)-one

4-Chloro-2,3-dihydro-1H-indole-2-one

4-Chloroindoline-2-one

4-chloroindolin-2-one

4-Chloro-1,3-dihydro-2H-indol-2-one, 4-Chloroindolin-2-one

2H-Indol-2-one, 4-chloro-1,3-dihydro-

20870-77-3

Halides

Pyrroles & Indoles