3-methylcyclobutane-1-carboxylic acid

3-methylcyclobutane-1-carboxylic acid Property

Boiling point:

194℃

Density 

1.105

Flash point:

88℃

storage temp. 

Sealed in dry,Room Temperature

pka

4.81±0.40(Predicted)

Appearance

Colorless to light yellow Liquid

Safety

Hazard Codes 

Xn

Risk Statements 

22-36-52

Safety Statements 

26

RIDADR 

3265

HazardClass 

8

PackingGroup 

Ⅲ

HS Code 

2916200090

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

3-methylcyclobutane-1-carboxylic acid Chemical Properties,Usage,Production

Uses

3-Methylcyclobutanecarboxylic acid is a reactant used in the preparation of alternating copolymers via. ring-opening metathesis polymerization (ROMP) of methylcyclobutene and dimethylcyclobutene.

Synthesis

General procedure for the synthesis of 3-methylenecyclobutanecarboxylic acid from 3-methylenecyclobutanecarboxylic acid: 3-methylenecyclobutanecarboxylic acid (1 g) was mixed with Pd/C catalyst (0.19 g) in methanol (20 mL) and the reaction was stirred overnight at room temperature in a hydrogen atmosphere (H2 balloon). Upon completion of the reaction, the mixture was filtered to remove the catalyst and the filtrate was concentrated under vacuum to give the target product 3-methylcyclobutyric acid (760 mg). Mass spectrometry analysis (ESI): calculated mass of C6H10O2 was 114; no corresponding mass was detected.

References

[1] Patent: WO2015/180613, 2015, A1. Location in patent: Page/Page column 20