4-[(3-Chloro-4-fluorophenyl)amino]-6-[(3-pyridinylmethyl)amino]-1,7-naphthyridine-3-carbonitrile

Product Name: 4-[(3-Chloro-4-fluorophenyl)amino]-6-[(3-pyridinylmethyl)amino]-1,7-naphthyridine-3-carbonitrile
CAS No.: 871307-18-5
Chemical Name: 4-[(3-Chloro-4-fluorophenyl)amino]-6-[(3-pyridinylmethyl)amino]-1,7-naphthyridine-3-carbonitrile
Synonyms: TC-S 7006;Tpl2-IN-2p;Tpl2 Kinase Inhibitor;Tpl2 Kinase Inhibitor 1;Tpl2 Kinase Inhibitor 1,Tpl-2 Kinase Inhibitor 1;4-(3-chloro-4-fluorophenylamino)-6-(pyridin-3-ylmethylamino)-1,7-naphthyridine-3-carbonitrile;4-[(3-Chloro-4-fluorophenyl)amino]-6-[(3-pyridinylmethyl)amino]-1,7-naphthyridine-3-carbonitrile;1,7-Naphthyridine-3-carbonitrile, 4-[(3-chloro-4-fluorophenyl)amino]-6-[(3-pyridinylmethyl)amino]-
CBNumber: CB41458318
Molecular Formula: C21H14ClFN6
Formula Weight: 404.83
MOL File: 871307-18-5.mol

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4-[(3-Chloro-4-fluorophenyl)amino]-6-[(3-pyridinylmethyl)amino]-1,7-naphthyridine-3-carbonitrile Property

Boiling point:: 616.3±55.0 °C(Predicted)
Density: 1.45
storage temp.: 2-8°C
solubility: DMF: 1 mg/ml; DMF:PBS(pH7.2) (1:2): 0.33 mg/ml; DMSO: 1 mg/ml
form: A crystalline solid
pka: 4.80±0.10(Predicted)
color: Yellow to green
InChI: 1S/C21H14ClFN6/c22-17-6-15(3-4-18(17)23)29-21-14(8-24)11-26-19-12-28-20(7-16(19)21)27-10-13-2-1-5-25-9-13/h1-7,9,11-12H,10H2,(H,26,29)(H,27,28)
InChIKey: NMEUKWOOQOHUNA-UHFFFAOYSA-N
SMILES: Fc1c(cc(cc1)Nc2c3c(ncc2C#N)cnc(c3)NCc4cnccc4)Cl

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Safety

WGK Germany: WGK 2
Storage Class: 11 - Combustible Solids
Hazard Classifications: Eye Irrit. 2
Skin Irrit. 2

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 616373
Product name: Tpl2 Kinase Inhibitor
Purity: The Tpl2 Kinase Inhibitor, also referenced under CAS 871307-18-5, controls the biological activity of Tpl2 Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphor
Packaging: 1 mg
Price: $238
Updated: 2026/03/19

Cayman Chemical

Product number: 19710
Product name: Tpl2 Kinase Inhibitor
Purity: ≥98%
Packaging: 1mg
Price: $57
Updated: 2024/03/01

Cayman Chemical

Product number: 19710
Product name: Tpl2 Kinase Inhibitor
Purity: ≥98%
Packaging: 5mg
Price: $220
Updated: 2024/03/01

Cayman Chemical

Product number: 19710
Product name: Tpl2 Kinase Inhibitor
Purity: ≥98%
Packaging: 10mg
Price: $302
Updated: 2024/03/01

Cayman Chemical

Product number: 19710
Product name: Tpl2 Kinase Inhibitor
Purity: ≥98%
Packaging: 25mg
Price: $684
Updated: 2024/03/01

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4-[(3-Chloro-4-fluorophenyl)amino]-6-[(3-pyridinylmethyl)amino]-1,7-naphthyridine-3-carbonitrile Chemical Properties,Usage,Production

Description

Tpl2 kinase inhibitor is an inhibitor of tumor progression locus 2 (Tpl2; IC₅₀ = 0.05 μM). It is selective for Tpl2 over MEK, p38 MAPK, Src, MK2, and PKC (IC₅₀s = >40, 180, >400, 110, and >400 μM, respectively). Tpl2 kinase inhibitor inhibits LPS-induced TNF-α production in isolated human monocytes and whole blood (IC₅₀s = 0.7 and 8.5 μM, respectively). It enhances differentiation induced by 1,25-dihydroxy vitamin D₃ (calcitriol; ) in HL-60 and U937 leukemia cells when used at a concentration of 5 μM. Tpl2 kinase inhibitor (5 μM) inhibits the proliferation of KG-1a leukemia cells.

Uses

TC-S 7006 is a Tpl2 kinase inhibitor.

IC 50

MAP3K8; p38: 180 μM (IC₅₀); MK2: 110 μM (IC₅₀)

storage

Store at -20°C

References

[1] NEAL GREEN et al. et al. Inhibition of Tpl2 Kinase and TNF-α Production with 1,7-Naphthyridine-3-carbonitriles: Synthesis and Structure—Activity Relationships.[J]. ChemInform, 2006, 37 9. DOI: 10.1002/chin.200609160
[2] XUENING WANG George P S. Expression of MAP3 kinase COT1 is up-regulated by 1,25-dihydroxyvitamin D3 in parallel with activated c-jun during differentiation of human myeloid leukemia cells[J]. Journal of Steroid Biochemistry and Molecular Biology, 2010, 121 1: Pages 395-398. DOI: 10.1016/j.jsbmb.2010.03.016
[3] XUENING WANG. Inhibition of Cot1/Tlp2 oncogene in AML cells reduces ERK5 activation and up-regulates p27Kip1 concomitant with enhancement of differentiation and cell cycle arrest induced by silibinin and 1,25-dihydroxyvitamin D(3).[J]. Cell Cycle, 2010, 9 22: 4542-4551. DOI: 10.4161/cc.9.22.13790

4-[(3-Chloro-4-fluorophenyl)amino]-6-[(3-pyridinylmethyl)amino]-1,7-naphthyridine-3-carbonitrile Preparation Products And Raw materials

Raw materials

Preparation Products

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4-[(3-Chloro-4-fluorophenyl)amino]-6-[(3-pyridinylmethyl)amino]-1,7-naphthyridine-3-carbonitrile Suppliers

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871307-18-5, 4-[(3-Chloro-4-fluorophenyl)amino]-6-[(3-pyridinylmethyl)amino]-1,7-naphthyridine-3-carbonitrileRelated Search:

3-Aminopyridine 2-Aminopyridine 4-Dimethylaminopyridine ALTRENOGEST Glycine CHLOROPHENYLSILANE 4,4'-DDT 3,4'-DIAMINODIPHENYLMETHANE AMINO ACIDS Difluorochloromethane 3-Chloro-4-fluoroaniline 4-[(3-Chloro-4-fluorophenyl)amino]-6-[(3-pyridinylmethyl)amino]-1,7-naphthyridine-3-carbonitrile

4-(3-chloro-4-fluorophenylamino)-6-(pyridin-3-ylmethylamino)-1,7-naphthyridine-3-carbonitrile

Tpl2 Kinase Inhibitor

4-[(3-Chloro-4-fluorophenyl)amino]-6-[(3-pyridinylmethyl)amino]-1,7-naphthyridine-3-carbonitrile

Tpl2-IN-2p

TC-S 7006

1,7-Naphthyridine-3-carbonitrile, 4-[(3-chloro-4-fluorophenyl)amino]-6-[(3-pyridinylmethyl)amino]-

Tpl2 Kinase Inhibitor 1

Tpl2 Kinase Inhibitor 1,Tpl-2 Kinase Inhibitor 1

871307-18-5

C21H14ClFN6