ChemicalBook > CAS DataBase List > 4-[(3-Chloro-4-fluorophenyl)amino]-6-[(3-pyridinylmethyl)amino]-1,7-naphthyridine-3-carbonitrile

4-[(3-Chloro-4-fluorophenyl)amino]-6-[(3-pyridinylmethyl)amino]-1,7-naphthyridine-3-carbonitrile

Product Name
4-[(3-Chloro-4-fluorophenyl)amino]-6-[(3-pyridinylmethyl)amino]-1,7-naphthyridine-3-carbonitrile
CAS No.
871307-18-5
Chemical Name
4-[(3-Chloro-4-fluorophenyl)amino]-6-[(3-pyridinylmethyl)amino]-1,7-naphthyridine-3-carbonitrile
Synonyms
TC-S 7006;Tpl2-IN-2p;Tpl2 Kinase Inhibitor;Tpl2 Kinase Inhibitor 1;Tpl2 Kinase Inhibitor 1,Tpl-2 Kinase Inhibitor 1;4-(3-chloro-4-fluorophenylamino)-6-(pyridin-3-ylmethylamino)-1,7-naphthyridine-3-carbonitrile;4-[(3-Chloro-4-fluorophenyl)amino]-6-[(3-pyridinylmethyl)amino]-1,7-naphthyridine-3-carbonitrile;1,7-Naphthyridine-3-carbonitrile, 4-[(3-chloro-4-fluorophenyl)amino]-6-[(3-pyridinylmethyl)amino]-
CBNumber
CB41458318
Molecular Formula
C21H14ClFN6
Formula Weight
404.83
MOL File
871307-18-5.mol
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4-[(3-Chloro-4-fluorophenyl)amino]-6-[(3-pyridinylmethyl)amino]-1,7-naphthyridine-3-carbonitrile Property

Boiling point:
616.3±55.0 °C(Predicted)
Density 
1.45
storage temp. 
2-8°C
solubility 
DMF: 1 mg/ml; DMF:PBS(pH7.2) (1:2): 0.33 mg/ml; DMSO: 1 mg/ml
form 
A crystalline solid
pka
4.80±0.10(Predicted)
color 
Yellow to green
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
19710
Product name
Tpl2 Kinase Inhibitor
Purity
≥98%
Packaging
1mg
Price
$57
Updated
2024/03/01
Cayman Chemical
Product number
19710
Product name
Tpl2 Kinase Inhibitor
Purity
≥98%
Packaging
5mg
Price
$220
Updated
2024/03/01
Cayman Chemical
Product number
19710
Product name
Tpl2 Kinase Inhibitor
Purity
≥98%
Packaging
10mg
Price
$302
Updated
2024/03/01
Cayman Chemical
Product number
19710
Product name
Tpl2 Kinase Inhibitor
Purity
≥98%
Packaging
25mg
Price
$684
Updated
2024/03/01
Tocris
Product number
5240
Product name
TC-S7006
Purity
≥99%(HPLC)
Packaging
10
Price
$270
Updated
2021/12/16
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4-[(3-Chloro-4-fluorophenyl)amino]-6-[(3-pyridinylmethyl)amino]-1,7-naphthyridine-3-carbonitrile Chemical Properties,Usage,Production

Description

Tpl2 kinase inhibitor is an inhibitor of tumor progression locus 2 (Tpl2; IC50 = 0.05 μM). It is selective for Tpl2 over MEK, p38 MAPK, Src, MK2, and PKC (IC50s = >40, 180, >400, 110, and >400 μM, respectively). Tpl2 kinase inhibitor inhibits LPS-induced TNF-α production in isolated human monocytes and whole blood (IC50s = 0.7 and 8.5 μM, respectively). It enhances differentiation induced by 1,25-dihydroxy vitamin D3 (calcitriol; ) in HL-60 and U937 leukemia cells when used at a concentration of 5 μM. Tpl2 kinase inhibitor (5 μM) inhibits the proliferation of KG-1a leukemia cells.

Uses

TC-S 7006 is a Tpl2 kinase inhibitor.

storage

Store at -20°C

4-[(3-Chloro-4-fluorophenyl)amino]-6-[(3-pyridinylmethyl)amino]-1,7-naphthyridine-3-carbonitrile Preparation Products And Raw materials

Raw materials

Preparation Products

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4-[(3-Chloro-4-fluorophenyl)amino]-6-[(3-pyridinylmethyl)amino]-1,7-naphthyridine-3-carbonitrile Suppliers

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871307-18-5, 4-[(3-Chloro-4-fluorophenyl)amino]-6-[(3-pyridinylmethyl)amino]-1,7-naphthyridine-3-carbonitrileRelated Search:

3-Aminopyridine 2-Aminopyridine Glycine 4-Dimethylaminopyridine ALTRENOGEST CHLOROPHENYLSILANE 97 4,4'-DDT 3,4'-DIAMINODIPHENYLMETHANE AMINO ACIDS Difluorochloromethane 3-Chloro-4-fluoroaniline 4-[(3-Chloro-4-fluorophenyl)amino]-6-[(3-pyridinylmethyl)amino]-1,7-naphthyridine-3-carbonitrile

  • 4-(3-chloro-4-fluorophenylamino)-6-(pyridin-3-ylmethylamino)-1,7-naphthyridine-3-carbonitrile
  • Tpl2 Kinase Inhibitor
  • 4-[(3-Chloro-4-fluorophenyl)amino]-6-[(3-pyridinylmethyl)amino]-1,7-naphthyridine-3-carbonitrile
  • Tpl2-IN-2p
  • TC-S 7006
  • 1,7-Naphthyridine-3-carbonitrile, 4-[(3-chloro-4-fluorophenyl)amino]-6-[(3-pyridinylmethyl)amino]-
  • Tpl2 Kinase Inhibitor 1
  • Tpl2 Kinase Inhibitor 1,Tpl-2 Kinase Inhibitor 1
  • 871307-18-5
  • C21H14ClFN6