ChemicalBook > CAS DataBase List > 4-[(3-Chloro-4-fluorophenyl)amino]-6-[(3-pyridinylmethyl)amino]-1,7-naphthyridine-3-carbonitrile

4-[(3-Chloro-4-fluorophenyl)amino]-6-[(3-pyridinylmethyl)amino]-1,7-naphthyridine-3-carbonitrile

Product Name: 4-[(3-Chloro-4-fluorophenyl)amino]-6-[(3-pyridinylmethyl)amino]-1,7-naphthyridine-3-carbonitrile
CAS No.: 871307-18-5
Chemical Name: 4-[(3-Chloro-4-fluorophenyl)amino]-6-[(3-pyridinylmethyl)amino]-1,7-naphthyridine-3-carbonitrile
Synonyms: TC-S 7006;Tpl2-IN-2p;Tpl2 Kinase Inhibitor;Tpl2 Kinase Inhibitor 1;Tpl2 Kinase Inhibitor 1,Tpl-2 Kinase Inhibitor 1;4-(3-chloro-4-fluorophenylamino)-6-(pyridin-3-ylmethylamino)-1,7-naphthyridine-3-carbonitrile;4-[(3-Chloro-4-fluorophenyl)amino]-6-[(3-pyridinylmethyl)amino]-1,7-naphthyridine-3-carbonitrile;1,7-Naphthyridine-3-carbonitrile, 4-[(3-chloro-4-fluorophenyl)amino]-6-[(3-pyridinylmethyl)amino]-
CBNumber: CB41458318
Molecular Formula: C21H14ClFN6
Formula Weight: 404.83
MOL File: 871307-18-5.mol

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4-[(3-Chloro-4-fluorophenyl)amino]-6-[(3-pyridinylmethyl)amino]-1,7-naphthyridine-3-carbonitrile Property

Boiling point:: 616.3±55.0 °C(Predicted)
Density: 1.45
storage temp.: 2-8°C
solubility: DMF: 1 mg/ml; DMF:PBS(pH7.2) (1:2): 0.33 mg/ml; DMSO: 1 mg/ml
form: A crystalline solid
pka: 4.80±0.10(Predicted)
color: Yellow to green

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 616373
Product name: Tpl2 Kinase Inhibitor
Purity: The Tpl2 Kinase Inhibitor, also referenced under CAS 871307-18-5, controls the biological activity of Tpl2 Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphor
Packaging: 1 mg
Price: $222
Updated: 2025/07/31

Cayman Chemical

Product number: 19710
Product name: Tpl2 Kinase Inhibitor
Purity: ≥98%
Packaging: 1mg
Price: $57
Updated: 2024/03/01

Cayman Chemical

Product number: 19710
Product name: Tpl2 Kinase Inhibitor
Purity: ≥98%
Packaging: 5mg
Price: $220
Updated: 2024/03/01

Cayman Chemical

Product number: 19710
Product name: Tpl2 Kinase Inhibitor
Purity: ≥98%
Packaging: 10mg
Price: $302
Updated: 2024/03/01

Cayman Chemical

Product number: 19710
Product name: Tpl2 Kinase Inhibitor
Purity: ≥98%
Packaging: 25mg
Price: $684
Updated: 2024/03/01

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4-[(3-Chloro-4-fluorophenyl)amino]-6-[(3-pyridinylmethyl)amino]-1,7-naphthyridine-3-carbonitrile Chemical Properties,Usage,Production

Description

Tpl2 kinase inhibitor is an inhibitor of tumor progression locus 2 (Tpl2; IC₅₀ = 0.05 μM). It is selective for Tpl2 over MEK, p38 MAPK, Src, MK2, and PKC (IC₅₀s = >40, 180, >400, 110, and >400 μM, respectively). Tpl2 kinase inhibitor inhibits LPS-induced TNF-α production in isolated human monocytes and whole blood (IC₅₀s = 0.7 and 8.5 μM, respectively). It enhances differentiation induced by 1,25-dihydroxy vitamin D₃ (calcitriol; ) in HL-60 and U937 leukemia cells when used at a concentration of 5 μM. Tpl2 kinase inhibitor (5 μM) inhibits the proliferation of KG-1a leukemia cells.

Uses

TC-S 7006 is a Tpl2 kinase inhibitor.

IC 50

MAP3K8; p38: 180 μM (IC₅₀); MK2: 110 μM (IC₅₀)

storage

Store at -20°C

References

[1] NEAL GREEN et al. et al. Inhibition of Tpl2 Kinase and TNF-α Production with 1,7-Naphthyridine-3-carbonitriles: Synthesis and Structure—Activity Relationships.[J]. ChemInform, 2006, 37 9. DOI: 10.1002/chin.200609160
[2] XUENING WANG George P S. Expression of MAP3 kinase COT1 is up-regulated by 1,25-dihydroxyvitamin D3 in parallel with activated c-jun during differentiation of human myeloid leukemia cells[J]. Journal of Steroid Biochemistry and Molecular Biology, 2010, 121 1: Pages 395-398. DOI: 10.1016/j.jsbmb.2010.03.016
[3] XUENING WANG. Inhibition of Cot1/Tlp2 oncogene in AML cells reduces ERK5 activation and up-regulates p27Kip1 concomitant with enhancement of differentiation and cell cycle arrest induced by silibinin and 1,25-dihydroxyvitamin D(3).[J]. Cell Cycle, 2010, 9 22: 4542-4551. DOI: 10.4161/cc.9.22.13790

4-[(3-Chloro-4-fluorophenyl)amino]-6-[(3-pyridinylmethyl)amino]-1,7-naphthyridine-3-carbonitrile Preparation Products And Raw materials

Raw materials

Preparation Products

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871307-18-5, 4-[(3-Chloro-4-fluorophenyl)amino]-6-[(3-pyridinylmethyl)amino]-1,7-naphthyridine-3-carbonitrileRelated Search:

3-Aminopyridine 2-Aminopyridine Glycine 4-Dimethylaminopyridine ALTRENOGEST CHLOROPHENYLSILANE 4,4'-DDT 3,4'-DIAMINODIPHENYLMETHANE AMINO ACIDS Difluorochloromethane 3-Chloro-4-fluoroaniline 4-[(3-Chloro-4-fluorophenyl)amino]-6-[(3-pyridinylmethyl)amino]-1,7-naphthyridine-3-carbonitrile

4-(3-chloro-4-fluorophenylamino)-6-(pyridin-3-ylmethylamino)-1,7-naphthyridine-3-carbonitrile

Tpl2 Kinase Inhibitor

4-[(3-Chloro-4-fluorophenyl)amino]-6-[(3-pyridinylmethyl)amino]-1,7-naphthyridine-3-carbonitrile

Tpl2-IN-2p

TC-S 7006

1,7-Naphthyridine-3-carbonitrile, 4-[(3-chloro-4-fluorophenyl)amino]-6-[(3-pyridinylmethyl)amino]-

Tpl2 Kinase Inhibitor 1

Tpl2 Kinase Inhibitor 1,Tpl-2 Kinase Inhibitor 1

871307-18-5

C21H14ClFN6