ethyl 1-benzyl-4-oxo-pyrrolidine-3-carboxylate
- Product Name
- ethyl 1-benzyl-4-oxo-pyrrolidine-3-carboxylate
- CAS No.
- 1027-35-6
- Chemical Name
- ethyl 1-benzyl-4-oxo-pyrrolidine-3-carboxylate
- Synonyms
- Ethyl 1-benzyl-4-pyrrolidone-3-carboxylate;ethyl-benzyl-4-oxopyrrolidine-3-carboxylate;Ethyl 1-benzyl-4-oxo-3-pyrrolidinecarboxylate;ethyl 1-benzyl-4-oxo-pyrrolidine-3-carboxylate;Ethyl 4-oxo-1-(benzyl)-pyrrolidine-3-carboxylate;Ethyl 4-oxo-1-(phenylmethyl)-3-pyrrolidinecarboxylate;ethyl 4-oxo-1-(phenylmethyl)pyrrolidine-3-carboxylate;1-Benzyl-4-oxo-pyrrolidine-3-carboxylic acid ethyl ester;1-(benzyl)-4-keto-pyrrolidine-3-carboxylic acid ethyl ester;4-oxo-1-(phenylmethyl)-3-Pyrrolidinecarboxylic acid ethyl ester
- CBNumber
- CB41459704
- Molecular Formula
- C14H17NO3
- Formula Weight
- 247.29
- MOL File
- 1027-35-6.mol
ethyl 1-benzyl-4-oxo-pyrrolidine-3-carboxylate Property
- Boiling point:
- 358.1±42.0 °C(Predicted)
- Density
- 1.184
- storage temp.
- Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
- pka
- 10.88±0.20(Predicted)
- form
- liquid
- color
- Light yellow
- InChI
- InChI=1S/C14H17NO3/c1-2-18-14(17)12-9-15(10-13(12)16)8-11-6-4-3-5-7-11/h3-7,12H,2,8-10H2,1H3
- InChIKey
- XLKXIFXOWMGWNT-UHFFFAOYSA-N
- SMILES
- N1(CC2=CC=CC=C2)CC(=O)C(C(OCC)=O)C1
Safety
- HazardClass
- IRRITANT
- HS Code
- 2921309990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
N-Bromosuccinimide Price
- Product number
- E900065
- Product name
- Ethyl1-Benzyl-4-oxopyrrolidine-3-carboxylate
- Packaging
- 50mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- E900065
- Product name
- Ethyl1-Benzyl-4-oxopyrrolidine-3-carboxylate
- Packaging
- 500mg
- Price
- $90
- Updated
- 2021/12/16
- Product number
- J50411
- Product name
- Ethyl1-benzyl-4-oxopyrrolidine-3-carboxylate
- Packaging
- 1g
- Price
- $72
- Updated
- 2021/12/16
- Product number
- 4H58-1-TT
- Product name
- Ethyl 1-benzyl-4-oxopyrrolidine-3-carboxylate
- Purity
- 97.0%
- Packaging
- 250mg
- Price
- $85
- Updated
- 2021/12/16
- Product number
- 0664AA
- Product name
- Ethyl1-benzyl-4-oxopyrrolidine-3-carboxylate
- Packaging
- 1g
- Price
- $97
- Updated
- 2021/12/16
ethyl 1-benzyl-4-oxo-pyrrolidine-3-carboxylate Chemical Properties,Usage,Production
Synthesis
795-18-6
1027-35-6
General procedure for the synthesis of ethyl 1-benzyl-4-keto-3-pyrrolidinecarboxylate from ethyl 3-(benzyl(2-ethoxy-2-oxoethyl)amino)propanoate: 1127.324 g of the crude product, compound (c), was dissolved in anhydrous 2.5 L of toluene, and 243.028 g of potassium tert-butanolate was slowly added under ice bath conditions with continuous stirring for 2 hours. The reaction process was monitored by thin layer chromatography (TLC). Upon completion of the reaction, the reaction solution was adjusted to acidic by adding 4 M hydrochloric acid in an ice bath, followed by adjusting the pH to 8 with saturated sodium bicarbonate solution.The reaction mixture was extracted with ethyl acetate, and the organic phase was dried with anhydrous sodium sulfate, filtered, and then concentrated by rotary evaporator to give 376.7 g of the pink solid compound (d) in 98% yield.
References
[1] Patent: CN102584828, 2016, B. Location in patent: Paragraph 0102-0104
[2] Patent: EP1552842, 2005, A1. Location in patent: Page/Page column 302
[3] Synthetic Communications, 1996, vol. 26, # 9, p. 1657 - 1661
ethyl 1-benzyl-4-oxo-pyrrolidine-3-carboxylate Preparation Products And Raw materials
Raw materials
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View Lastest Price from ethyl 1-benzyl-4-oxo-pyrrolidine-3-carboxylate manufacturers
- Product
- Ethyl 1-benzyl-4-oxo-3-pyrrolidinecarboxylate 1027-35-6
- Price
- US $2.20-8.80/kg
- Min. Order
- 1kg
- Purity
- 99%min
- Supply Ability
- 100kg
- Release date
- 2025-09-08
- Product
- ethyl 1-benzyl-4-oxo-pyrrolidine-3-carboxylate 1027-35-6
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 98$
- Supply Ability
- 200kg
- Release date
- 2019-08-30