Ethyl L-pyroglutamate

Product Name: Ethyl L-pyroglutamate
CAS No.: 7149-65-7
Chemical Name: Ethyl L-pyroglutamate
Synonyms: PYR-OET;NSC 7227;pGlu-OEt;H-PYR-OET;NSC 72279;L-Pyr-OEt;Saxaint-A;NSC 166529;L-Pyr-Oet-OH;(S)-+-H-PYR-OET
CBNumber: CB6459440
Molecular Formula: C7H11NO3
Formula Weight: 157.17
MOL File: 7149-65-7.mol

More

Less

Ethyl L-pyroglutamate Property

Melting point:: 54-56 °C
alpha: -3.5 º (c=5, water)
Boiling point:: 176 °C12 mm Hg(lit.)
Density: 1.2483 (rough estimate)
refractive index: 1.4310 (estimate)
Flash point:: >230 °F
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
form: Low Melting Solid
pka: 14.78±0.40(Predicted)
color: White to cream
optical activity: [α]19/D +3.3°, c = 10 in ethanol
BRN: 82621
InChI: InChI=1S/C7H11NO3/c1-2-11-7(10)5-3-4-6(9)8-5/h5H,2-4H2,1H3,(H,8,9)/t5-/m0/s1
InChIKey: QYJOOVQLTTVTJY-YFKPBYRVSA-N
SMILES: C(OCC)(=O)[C@@H]1CCC(=O)N1
LogP: -1.390 (est)
CAS DataBase Reference: 7149-65-7(CAS DataBase Reference)

More

Less

Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36-37/39
WGK Germany: 3
F: 3-10
HS Code: 29339900

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More

Less

N-Bromosuccinimide Price

TCI Chemical

Product number: P2929
Product name: Ethyl L-Pyroglutamate
Purity: min. 98.0 %
Packaging: 5G
Price: $36
Updated: 2025/07/31

TCI Chemical

Product number: P2929
Product name: Ethyl L-Pyroglutamate
Purity: min. 98.0 %
Packaging: 25G
Price: $69
Updated: 2025/07/31

TRC

Product number: E901276
Product name: (S)-(+)-5-Ethylcarboxyl-2-pyrrolidinone
Packaging: 25g
Price: $1075
Updated: 2021/12/16

Medical Isotopes, Inc.

Product number: 10020
Product name: (S)-(+)-5-Ethylcarboxyl-2-pyrrolidinone
Packaging: 5G
Price: $1880
Updated: 2021/12/16

Chem-Impex

Product number: 14022
Product name: L-Pyroglutamicacidethylester,98%(HPLC)
Purity: 98%(HPLC)
Packaging: 1KG
Price: $364
Updated: 2021/12/16

More

Less

Ethyl L-pyroglutamate Chemical Properties,Usage,Production

Chemical Properties

White to cream low melting solid

Uses

(S)-(+)-5-Ethylcarboxyl-2-pyrrolidinone (cas# 7149-65-7) is a compound useful in organic synthesis.

reaction suitability

reaction type: solution phase peptide synthesis

Synthesis

64-17-5

98-79-3

7149-65-7

30.0 g (232 mmol) of L-pyroglutamic acid was suspended in 100 mL of anhydrous ethanol and 20 mL (274 mmol, 1.2 eq.) of SOCl2 was slowly added dropwise at 0 °C. After the dropwise addition, the reaction mixture was stirred at 0 °C for 15 h. The reaction mixture was then allowed to warm up naturally to room temperature, resulting in a clarified solution. After completion of the reaction, all volatile components were removed under reduced pressure. The residue was dissolved in 500 mL of ethyl acetate and treated sequentially with K2CO3 and MgSO4 with stirring, removing the desiccant by filtration after each treatment. The solution was filtered through a small amount of silica gel and concentrated under reduced pressure to give 36.0 g (230 mmol, 99% yield) of the target product, ethyl (S)-5-oxopyrrolidine-2-carboxylate, in the form of a yellowish viscous oil. 2.22-2.48 (m, 3H, H-3α, H-4), 2.07-2.22 (m, 1H, H-3β), 1.22 (t, 3H, J = 7.1 Hz, ester CH3).13C-NMR (75 MHz, CDCl3): δ (ppm) = 178.37 (lactam CO), 172.10 (ester CO), 61.58 ( ester CH2), 55.59 (CH), 29.33 (CH2, C-4), 24.77 (CH2, C-3), 14.11 (ester CH3).

References

[1] Angewandte Chemie - International Edition, 2010, vol. 49, # 39, p. 7111 - 7115
[2] Patent: US2011/34438, 2011, A1. Location in patent: Page/Page column 20
[3] Patent: CN107304179, 2017, A. Location in patent: Paragraph 0033-0034
[4] Chemical Communications, 2014, vol. 50, # 68, p. 9690 - 9692
[5] Organic and Biomolecular Chemistry, 2006, vol. 4, # 21, p. 3894 - 3897

Ethyl L-pyroglutamate Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

Ethyl L-pyroglutamate Suppliers

Belgium 1 Canada 1 China 210 Europe 2 Germany 3 India 7 Japan 2 Switzerland 1 The Netherlands 1 Ukraine 1 United Kingdom 5 United States 28 USA 1 Global 263

Hubei Xinkang Pharmaceutical Chemical Co., Ltd

Tel: 027-027-59308705 18871579363
Fax: 027-59308705
Email: 1248680011@qq.com
Country: China
ProdList: 9850
Advantage: 58

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Meryer (Shanghai) Chemical Technology Co., Ltd.

Tel: 4006356688 18621169109
Fax: 86-21-61259102
Email: market03@meryer.com
Country: China
ProdList: 40228
Advantage: 62

Alfa Aesar

Tel: 400-6106006
Fax: 021-67582001/03/05
Email: saleschina@alfa-asia.com
Country: China
ProdList: 30123
Advantage: 84

Energy Chemical

Tel: 021-021-58432009 400-005-6266
Fax: 021-58436166
Email: sales8178@energy-chemical.com
Country: China
ProdList: 44801
Advantage: 61

Capot Chemical Co., Ltd

Tel: +86 (0) 571 85 58 67 18
Fax: 0086-571-85864795
Country: China
ProdList: 18207
Advantage: 66

Beijing Ouhe Technology Co., Ltd

Tel: 010-010-82967028 13522913783
Fax: +86-10-82967029
Email: 2355560935@qq.com
Country: China
ProdList: 12000
Advantage: 60

JinYan Chemicals(ShangHai) Co.,Ltd.

Tel: 13817811078
Fax: 86-021-50426522,50426273
Email: sales@jingyan-chemical.com
Country: China
ProdList: 9976
Advantage: 60

Jia Xing Isenchem Co.,Ltd

Tel: 0573-85285100 18627885956
Fax: 0573-85285100
Email: isenchem@163.com
Country: China
ProdList: 9310
Advantage: 66

Accela ChemBio Co.,Ltd.

Tel: 021-50795510 4000665055
Fax: 021-50795055
Email: sales@accelachem.com
Country: China
ProdList: 11035
Advantage: 64

More

Less

View Lastest Price from Ethyl L-pyroglutamate manufacturers

Hebei Chuanghai Biotechnology Co., Ltd

Product: Ethyl L-pyroglutamate 7149-65-7
Price: US $10.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 mt
Release date: 2024-12-04

Sichuan HongRi Pharma-Tech Co.,Ltd

Product: L-Pyr-Oet 7149-65-7
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1T+
Release date: 2024-04-09

Hebei Chuanghai Biotechnology Co,.LTD

Product: Ethyl L-Pyroglutamate 7149-65-7
Price: US $5.00-2.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10000kg
Release date: 2024-08-20

7149-65-7, Ethyl L-pyroglutamateRelated Search:

Ethyl acetate Ethyl vanillin Ethyl acrylate Ethylbenzene L-Glutamic acid Ethylparaben RESMETHRIN Povidone iodine Tris(trimethylsilyl)phosphate 2-Pyrrolidinone Polyglutamic acid Polyvinylpyrrolidone Ethyl propionate D-Proline N-Vinyl-2-pyrrolidone 1-Cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid ethyl ester Ethanol Ethyl formate

ETHYL L-PYROGLUTAMATE

ETHYL (S)-PYROGLUTAMATE

ETHYL (S)-2-PYRROLIDINONE-5-CARBOXYLATE

ETHYL (S)-(+)-2-PYRROLIDONE-5-CARBOXYLATE

ETHYL (S)-2-PYRROLIDONE-5-CARBOXYLATE

H-PYR-OET

ethyl 5-oxo-L-prolinate

(S)-(+)-5-Ethylcarboxyl-2-pyrrolidinone

5-Oxo-L-proline Ethyl Ester

L-PYROGLUTAMIC ACID ETHYL ESTER

5-OXO-PROLINE ETHYL ESTER

PYR-OET

SPECS AQ-405/40679537

(S)-ETHYL 2-PYRROLIDONE-5-CARBOXYLATE

(S)-5-OXOPROLINE ETHYL ESTER

Ethyl (2S)-5-Oxopyrrolidine-2-carboxylate

NSC 166529

NSC 7227

ETHYL(S)-(-)-2-PYRROLIDINE-5-CARBOXYLATE

ETHYL (S)-(+)-2-OXO-PYRROLIDINE-5-CARBOXYLATE

(S)-+-H-PYR-OET

NSC 72279

(S)-5-Oxoproline ethyl ester, L-Pyroglutamic acid ethyl ester

L-Proline, 5-oxo-, ethyl ester

Ethyl (S)-(+)-2-pyrrolidone-5-carboxylate,99%

(2S)-5-Oxo-2α-pyrrolidinecarboxylic acid ethyl ester

(S)-5-Oxo-2-pyrrolidinecarboxylic acid ethyl ester

Pyroglutamic acid ethyl ester

(S)-Ethyl 5-oxopyrrolidine-2-carboxylate

Ethyl-(S)-(+)-2-pyrrolidino-5-carboxylate

pGlu-OEt

Ethyl (S)-(+)-pyrrolidone-5-carboxylate

hyl L-pyroglutaMate

ethyl 5-oxoprolinate

Ethyl L-2-Pyrrolidinone-5-carboxylate

L-Pyr-OEt

L-Pyroglutamic acid ethyl ester≥ 98% (HPLC)

Saxaint-A

Ethyl (S)-(+)-2-pyrrolidone-5-carboxylate 98%

Ethyl L-pyroglutamate USP/EP/BP

Ethyl (S)-5-oxopyrrolidine-2-carboxylate

Ethyl L-pyroglutamatec

Ethyl (S)-(+)-2-pyrrolidinone-5-

L-Pyr-Oet-OH

(+)-L-Pyroglutamic acid ethyl ester

Ethyl (<i>S</i>)-(+)-2-pyrrolidone-5-carboxylate

Ethyl-L Pyroglutamates

7149-65-7

Peptide Synthesis

Pyroglutamine Derivatives

Specialty Synthesis

Unnatural Amino Acid Derivatives

pharmacetical

Heterocycles

Miscellaneous Reagents

Chiral Reagents

Pyroglutamic acid [Pyr, pGu]