CHS-828

Product Name: CHS-828
CAS No.: 200484-11-3
Chemical Name: CHS-828
Synonyms: MX1778;HS-828;GMX 1778;GMX1778, >98%;CHS828;CHS 828;MX1778? CHS-828;GMX1778(CHS-828);2-[6-(4-chlorophenoxy)hexyl]-1-cyano-3-pyridin-4-ylguanidine;1-[6-(4-Chlorophenoxy)hexyl]-3-cyano-2-pyridin-4-ylguanidine;1-(6-(4-chlorophenoxy)hexyl)-2-cyano-3-(pyridin-4-yl)guanidine
CBNumber: CB41463422
Molecular Formula: C19H22ClN5O
Formula Weight: 371.86
MOL File: 200484-11-3.mol

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CHS-828 Property

Melting point:: 166-168°C
Boiling point:: 532.1±58.0 °C(Predicted)
Density: 1.18±0.1 g/cm3(Predicted)
storage temp.: Inert atmosphere,Store in freezer, under -20°C
solubility: DMSO: soluble20mg/mL, clear
form: powder
pka: 7.36±0.10(Predicted)
color: white to beige
Stability:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
InChIKey: BOIPLTNGIAPDBY-UHFFFAOYSA-N

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Safety

Hazard Codes: T
Risk Statements: 25-36/37/38
Safety Statements: 26-45
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML0646
Product name: GMX1778
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $110
Updated: 2024/03/01

Sigma-Aldrich

Product number: SML0646
Product name: GMX1778
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $425
Updated: 2024/03/01

Cayman Chemical

Product number: 11021
Product name: CHS-828
Purity: ≥98%
Packaging: 5mg
Price: $73
Updated: 2024/03/01

Cayman Chemical

Product number: 11021
Product name: CHS-828
Purity: ≥98%
Packaging: 10mg
Price: $138
Updated: 2024/03/01

Cayman Chemical

Product number: 11021
Product name: CHS-828
Purity: ≥98%
Packaging: 25mg
Price: $324
Updated: 2024/03/01

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CHS-828 Chemical Properties,Usage,Production

Description

CHS-828 is a pyridyl cyanoguanidine anti-tumor agent that has been identified as a competitive inhibitor of Nampt as well as an inhibitor of NF-κB pathway activity. CHS-828 has potent cytotoxic effects in human breast (IC₅₀ = 7.3 nM) and lung cancer (IC₅₀ = 0.5 nM) cells both in vitro and in vivo. In nude mice bearing human tumor xenografts, CHS-828, at 20-50 mg/kg/day, inhibits the growth of MCF-7 breast cancer tumors and induces regression of NYH small cell lung cancer tumors.

Uses

GMX1778 is an anticancer agent that inhibits cellular synthesis of NAD.

Definition

ChEBI: 2-[6-(4-chlorophenoxy)hexyl]-1-cyano-3-pyridin-4-ylguanidine is an aromatic ether.

storage

+4°C

References

1) Olesen?et al.?(2008),?Anticancer agent CHS-828 inhibits cellular synthesis of NAD; Biochem. Biophys. Res. Commun.?376?799 2) Hassan?et al. (2006),?CHS 828 kill tumor cells by inhibiting the nuclear factor-kappaB translocation but unlikely through down-regulation of proteasome; Anticancer Res.?26?4431 3) Hjarnaa?et al.?(1999),?CHS 828, a novel pyridyl cyanoguanidine with potent antitumor activity in vitro and in vivo; Cancer Res.?59?5751 4) Cerna?et al.?(2012)?Inhibition of nicotinamide phosphoribosyltransferase (NAMPT) activity by small molecule GMX1778 regulates reactive oxygen species (ROS)-mediated cytotoxicity in a p53- and nicotinic acid phosphoribosyltransferase1 (NAPRT1)-dependent manner; J. Biol. Chem.?287?22408

CHS-828 Preparation Products And Raw materials

Raw materials

Preparation Products

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CHS-828 Suppliers

China 81 India 2 United States 16 Global 99

Target molecule Corp.

Tel: 857-239-0968
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Musechem

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TargetMol Chemicals Inc.

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InvivoChem

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Santa Cruz Biotechnology, Inc.

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View Lastest Price from CHS-828 manufacturers

Career Henan Chemical Co

Product: CHS-828 200484-11-3
Price: US $1.00/ASSAYS
Min. Order: 1ASSAYS
Purity: 95%~99%
Supply Ability: per week:100kg
Release date: 2019-09-05

200484-11-3, CHS-828Related Search:

CYCLOPAMINE S-Trityl-L-cysteine AG 490 (+)-Camptothecin N-ACETYLLACTOSAMINE

GMX 1778

N-[6-(4-Chlorophenoxy)hexyl]-N'-cyano-N''-4-pyridinylguanidine

1-(6-(4-chlorophenoxy)hexyl)-2-cyano-3-(pyridin-4-yl)guanidine

GMX1778(CHS-828)

2-[6-(4-chlorophenoxy)hexyl]-1-cyano-3-pyridin-4-ylguanidine

CHS828;CHS 828

GMX1778, >98%

HS-828

MX1778

Guanidine, N-[6-(4-chlorophenoxy)hexyl]-N'-cyano-N''-4-pyridinyl-

1-[6-(4-Chlorophenoxy)hexyl]-3-cyano-2-pyridin-4-ylguanidine

Nicotinamide phosphoribosyl transferase,NAMPT,inhibit,PBEF,Visfatin,Apoptosis,Inhibitor,Pre-B cell colony enhancing factor,CHS-828,GMX-1778,CHS828,GMX 1778

Guanidine, N-[6-(4-chlorophenoxy)hexyl]-N'-cyano-N''-4-pyridinyl-

MX1778? CHS-828

200484-11-3

Inhibitors