2-Cyano-3-methyl-5-nitropyridine

Product Name: 2-Cyano-3-methyl-5-nitropyridine
CAS No.: 65169-63-3
Chemical Name: 2-Cyano-3-methyl-5-nitropyridine
Synonyms: 3-Methyl-5-nitropicolinonitrile;3-Cyano-2-Methyl-5-nitropyridine;2-Cyano-3-methyl-5-nitropyridine;3-methyl-5-nitro-2-Pyridinecarbonitrile;2-Pyridinecarbonitrile, 3-methyl-5-nitro-
CBNumber: CB41471128
Molecular Formula: C7H5N3O2
Formula Weight: 163.13
MOL File: 65169-63-3.mol

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2-Cyano-3-methyl-5-nitropyridine Property

Melting point:: 75-76 °C(Solv: hexane (110-54-3))
Boiling point:: 366.6±42.0 °C(Predicted)
Density: 1.34±0.1 g/cm3(Predicted)
storage temp.: Inert atmosphere,Room Temperature
pka: -4.06±0.20(Predicted)
Appearance: Light yellow to yellow Solid

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Safety

HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

AK Scientific

Product number: Y5001
Product name: 2-Cyano-3-methyl-5-nitropyridine
Packaging: 250mg
Price: $45
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H54-1-F7
Product name: 2-Cyano-3-methyl-5-nitropyridine
Purity: 98%
Packaging: 1g
Price: $90
Updated: 2021/12/16

Matrix Scientific

Product number: 153083
Product name: 3-Methyl-5-nitropicolinonitrile
Purity: 95%
Packaging: 1g
Price: $296
Updated: 2021/12/16

AK Scientific

Product number: Y5001
Product name: 2-Cyano-3-methyl-5-nitropyridine
Packaging: 10g
Price: $481
Updated: 2021/12/16

AK Scientific

Product number: J96781
Product name: 2-Cyano-3-methyl-5-nitropyridine
Packaging: 25g
Price: $750
Updated: 2021/12/16

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2-Cyano-3-methyl-5-nitropyridine Chemical Properties,Usage,Production

Synthesis

20970-75-6

65169-63-3

The general procedure for the synthesis of 2-cyano-3-methyl-5-nitropyridine from 2-cyano-3-methylpyridine was as follows: 3-methylpyridine-2-carbonitrile (128 g, 1.08 mol) and tetrabutylammonium nitrate (363 g, 1.19 mol) were dissolved in tertiary-butylmethyl ether (1.3 L) and the mixture was cooled down to 4 °C. Trifluoroacetic anhydride (171 mL, 1.21 mol) was slowly added under stirring, followed by continuous stirring of the reaction mixture for 60 hours at room temperature. Upon completion of the reaction, the pH of the mixture was adjusted to about 7 with 20% aqueous sodium hydroxide solution and then extracted with dichloromethane (3 x 1 L). The organic layers were combined, dried with anhydrous sodium sulfate, filtered and concentrated under reduced pressure. Purification of the crude product by silica gel column chromatography (elution gradient: 0% to 10% petroleum ether solution of ethyl acetate) afforded the target compound 2-cyano-3-methyl-5-nitropyridine as a yellow solid. Yield: 70 g, 0.43 mmol, 40% yield.1H NMR (400 MHz, CDCl3) δ 9.31-9.36 (m, 1H), 8.47-8.52 (m, 1H), 2.74 (s, 3H).

References

[1] Bioorganic and Medicinal Chemistry, 1999, vol. 7, # 9, p. 1845 - 1855
[2] Patent: WO2015/155626, 2015, A1. Location in patent: Page/Page column 89; 90
[3] Patent: WO2017/51294, 2017, A1. Location in patent: Page/Page column 57; 58
[4] Patent: WO2017/51303, 2017, A1. Location in patent: Page/Page column 72; 73
[5] Patent: WO2017/51276, 2017, A1. Location in patent: Page/Page column 99

2-Cyano-3-methyl-5-nitropyridine Preparation Products And Raw materials

Raw materials

Preparation Products

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2-Cyano-3-methyl-5-nitropyridine Suppliers

China 29 Germany 1 India 1 United States 3 Global 34

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Synchem OHG

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View Lastest Price from 2-Cyano-3-methyl-5-nitropyridine manufacturers

Career Henan Chemical Co

Product: 2-Cyano-3-methyl-5-nitropyridine 65169-63-3
Price: US $5.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 100KG
Release date: 2020-01-12

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65169-63-3