2-Cyano-5-nitropyridine
- Product Name
- 2-Cyano-5-nitropyridine
- CAS No.
- 100367-55-3
- Chemical Name
- 2-Cyano-5-nitropyridine
- Synonyms
- 5-Nitropicolinonitrile;6-CYANO-3-NITROPYRIDINE;2-CYANO-5-NITROPYRIDINE;2-Cyano-5-nitropyridine 95+%;5-Nitropyridin-2-carbonitrile;5-Nitro-2-pyridinecarbonitrile;5-nitropyridine-2-carbonitrile;2-PYRIDINECARBONITRILE, 5-NITRO-;3-bromo-6-methyl-1H-pyridin-2-one;2-Pyridinecarbonitrile,5-nitro-(9CI)
- CBNumber
- CB7122336
- Molecular Formula
- C6H3N3O2
- Formula Weight
- 149.11
- MOL File
- 100367-55-3.mol
2-Cyano-5-nitropyridine Property
- Melting point:
- 43 °C
- Boiling point:
- 344.6±27.0 °C(Predicted)
- Density
- 1.41±0.1 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Room Temperature
- solubility
- Ethyl Acetate, Methanol
- form
- Solid
- pka
- -4.35±0.10(Predicted)
- color
- Green
- CAS DataBase Reference
- 100367-55-3(CAS DataBase Reference)
Safety
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- C8395-86
- Product name
- 2-Cyano-5-nitropyridine
- Packaging
- 100mg
- Price
- $403
- Updated
- 2021/12/16
- Product number
- C982025
- Product name
- 2-Cyano-5-nitropyridine
- Packaging
- 1g
- Price
- $970
- Updated
- 2021/12/16
- Product number
- FC00989
- Product name
- 2-Cyano-5-nitropyridine
- Packaging
- 10g
- Price
- $400
- Updated
- 2021/12/16
- Product number
- CHM0012842
- Product name
- 5-NITROPYRIDINE-2-CARBONITRILE
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $1593.9
- Updated
- 2021/12/16
- Product number
- CHM0012842
- Product name
- 5-NITROPYRIDINE-2-CARBONITRILE
- Purity
- 95.00%
- Packaging
- 100MG
- Price
- $704.55
- Updated
- 2021/12/16
2-Cyano-5-nitropyridine Chemical Properties,Usage,Production
Chemical Properties
Green Solid
Uses
2-Cyano-5-nitropyridine can be used as a useful synthetic intermediate.
Synthesis
4487-59-6
143-33-9
544-92-3
100367-55-3
Synthesis of Compound E: Copper(I) cyanide (662 mg, 7.34 mmol) and sodium cyanide (242 mg, 4.93 mmol) were dissolved in N,N-dimethylformamide (7.5 mL) and stirred at 150 °C for 25 min. Subsequently, a solution of 2-bromo-5-nitropyridine (113 mg, 0.700 mmol) dissolved in N,N-dimethylformamide (2.5 mL) (pre-dissolved completely at 100 °C) was added to the above mixture and the reaction was continued to be stirred at 150 °C for 100 min. The progress of the reaction was monitored by TLC (unfolding agent: ethyl acetate/hexane = 1:3). Upon completion of the reaction, the reaction was quenched by the addition of 10 mL of aqueous 1M potassium dihydrogen phosphate and extracted with ethyl acetate (50 mL x 3). The organic phases were combined and washed sequentially with water (100 mL) and saturated saline (100 mL). The organic layer was dried over anhydrous magnesium sulfate and filtered, and concentrated under reduced pressure to remove the solvent. The product was purified by fast column chromatography (eluent: ethyl acetate/hexane = 1:7→1:3) to afford 2-cyano-5-nitropyridine E (624 mg, 4.19 mmol) as a yellow oil in 85% yield.1H NMR (300 MHz, CDCl3) δ: 9.54 (dd, 1H, J = 2.5, 0.7 Hz, Py-H), 8.68 (dd, 1H, J = 8.4, 2.5 Hz, Py-H), 7.98 (dd, 1H, J = 8.4, 0.7 Hz, Py-H).
References
[1] Journal of Medicinal Chemistry, 2008, vol. 51, # 8, p. 2400 - 2411
[2] Patent: EP2070908, 2009, A1. Location in patent: Page/Page column 11-12
2-Cyano-5-nitropyridine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-Cyano-5-nitropyridine manufacturers
- Product
- 2-Cyano-5-nitropyridine 100367-55-3
- Price
- US $1.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 200kg
- Release date
- 2018-12-24