4-CHLORO-PYRIDINE-2-CARBONITRILE
- Product Name
- 4-CHLORO-PYRIDINE-2-CARBONITRILE
- CAS No.
- 19235-89-3
- Chemical Name
- 4-CHLORO-PYRIDINE-2-CARBONITRILE
- Synonyms
- 4-CHLOROPICOLINONITRILE;4-Chloro-2-pyridinecarbonitrile;IFLAB-BB F3099-7226;4-Chlorocyanopyridine;1-chloropicolinonitrile;4-CHLORO-2-CYANOPYRIDINE;2-Cyano-4-chloropyridine;4-Chloro-2-cyanopyridine >4-CHLORO-2-PYRIDINECARBONITRI&;4-Chloropyridin-2-carbonitrile
- CBNumber
- CB4464101
- Molecular Formula
- C6H3ClN2
- Formula Weight
- 138.55
- MOL File
- 19235-89-3.mol
4-CHLORO-PYRIDINE-2-CARBONITRILE Property
- Melting point:
- 81-85 °C
- Boiling point:
- 231.6±20.0 °C(Predicted)
- Density
- 1.33±0.1 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- form
- powder to crystal
- pka
- -2.74±0.10(Predicted)
- color
- White to Yellow to Orange
- InChI
- InChI=1S/C6H3ClN2/c7-5-1-2-9-6(3-5)4-8/h1-3H
- InChIKey
- DYEZRXLVZMZHQT-UHFFFAOYSA-N
- SMILES
- C1(C#N)=NC=CC(Cl)=C1
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H301Toxic if swalloed
H315Causes skin irritation
H318Causes serious eye damage
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 673544
- Product name
- 4-Chloro-2-pyridinecarbonitrile
- Purity
- 97%
- Packaging
- 5g
- Price
- $330
- Updated
- 2023/06/20
- Product number
- 673544
- Product name
- 4-Chloro-2-pyridinecarbonitrile
- Purity
- 97%
- Packaging
- 1g
- Price
- $64.9
- Updated
- 2022/05/15
- Product number
- C2732
- Product name
- 4-Chloro-2-cyanopyridine
- Purity
- >98.0%(GC)
- Packaging
- 1g
- Price
- $51
- Updated
- 2025/07/31
- Product number
- C2732
- Product name
- 4-Chloro-2-cyanopyridine
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $147
- Updated
- 2025/07/31
- Product number
- C596218
- Product name
- 4-Chloropyridine-2-carbonitrile
- Packaging
- 50mg
- Price
- $60
- Updated
- 2021/12/16
4-CHLORO-PYRIDINE-2-CARBONITRILE Chemical Properties,Usage,Production
Chemical Properties
Type of white solid
Uses
Substrate used to prepare chiral dialkylaminopyridines bearing a C-2 hydroxyalkyl group via biocatalysis.
Synthesis
1121-76-2
7677-24-9
19235-89-3
4-Chloropyridine N-oxide (7.53 g, 58.1 mmol) and N,N-dimethylcarbamoyl chloride (9.36 g, 87.0 mmol) were mixed in acetonitrile (200 mL). Subsequently, trimethylcyanosilane (11.5 g, 116 mmol) was added slowly and dropwise to the reaction system. The reaction mixture was stirred at room temperature for 18 hours. Upon completion of the reaction, the mixture was combined with ethyl acetate and water for extraction. The organic layer was washed sequentially with saturated aqueous sodium bicarbonate and saturated saline, and then dried with magnesium sulfate. The solvent was removed by distillation and the residue obtained was purified by column chromatography (silica gel 200 g) using hexane-ethyl acetate (3:1, v/v) as eluent. The target fraction was collected and concentrated to give 4-chloro-2-cyanopyridine (8.05 g, 99% yield) as a light yellow oil. The product was characterized by 1H-NMR (CDCl3) and IR (KBr): 1H-NMR δ 7.54-7.56 (1H, m), 7.72 (1H, s), 8.63 (1H, d, J = 5.3 Hz); IR 2239, 1568, 1549, 1462, 1379, 1288, 1215, 844, 704 cm-1.
References
[1] Patent: EP1424336, 2004, A1. Location in patent: Page 219
[2] Patent: US2006/160803, 2006, A1. Location in patent: Page/Page column 146
[3] Tetrahedron Asymmetry, 2005, vol. 16, # 20, p. 3427 - 3435
[4] Patent: WO2005/95326, 2005, A2. Location in patent: Page/Page column 225-226
[5] Patent: WO2005/87215, 2005, A1. Location in patent: Page/Page column 143
4-CHLORO-PYRIDINE-2-CARBONITRILE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-CHLORO-PYRIDINE-2-CARBONITRILE manufacturers
- Product
- 4-CHLORO-PYRIDINE-2-CARBONITRILE 19235-89-3
- Price
- US $10.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 20 ton
- Release date
- 2024-12-23
- Product
- 4-CHLORO-PYRIDINE-2-CARBONITRILE 19235-89-3
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.0% min
- Supply Ability
- 100 tons min
- Release date
- 2021-05-12
- Product
- 4-CHLORO-PYRIDINE-2-CARBONITRILE 19235-89-3
- Price
- US $3.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2019-08-07