5-BROMO-4-METHYL-PYRIDINE-2-CARBONITRILE

Product Name: 5-BROMO-4-METHYL-PYRIDINE-2-CARBONITRILE
CAS No.: 886364-86-9
Chemical Name: 5-BROMO-4-METHYL-PYRIDINE-2-CARBONITRILE
Synonyms: 102106;5-Bromo-2-cyano-4-methyL;5-BroMo-4-Methylpicolinonitrile;2-Cyano-4-methyl-5-bromopyridine;5-BroMo-2-cyano-4-Methylpyridine;5-Bromo-4-methyl-2-cyanopyridine;2-CYANO-5-BROMO-4-METHYL PYRIDINE;5-bromo-4-methyl-2-Pyridinecarbonitrile;5-BROMO-4-METHYL-PYRIDINE-2-CARBONITRILE;2-Pyridinecarbonitrile, 5-bromo-4-methyl-
CBNumber: CB8840828
Molecular Formula: C7H5BrN2
Formula Weight: 197.03
MOL File: Mol file

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5-BROMO-4-METHYL-PYRIDINE-2-CARBONITRILE Property

Boiling point:: 293.3±35.0 °C(Predicted)
Density: 1.61±0.1 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
pka: -2.02±0.18(Predicted)
form: powder
color: grey
InChI: InChI=1S/C7H5BrN2/c1-5-2-6(3-9)10-4-7(5)8/h2,4H,1H3
InChIKey: JAQLBGDFALXUMV-UHFFFAOYSA-N
SMILES: C1(C#N)=NC=C(Br)C(C)=C1

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Safety

Hazard Codes: Xn
Risk Statements: 22-37/38-41
Safety Statements: 26-39
RIDADR: UN2811
HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

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N-Bromosuccinimide Price

TRC

Product number: B405025
Product name: 5-bromo-4-methylpyridine-2-carbonitrile
Packaging: 25mg
Price: $45
Updated: 2021/12/16

Frontier Specialty Chemicals

Product number: B12736
Product name: 5-Bromo-4-methylpyridine-2-carbonitrile
Purity: 95%
Packaging: 1g
Price: $55
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB141871
Product name: 5-Bromo-4-methylpicolinonitrile
Packaging: 250mg
Price: $80
Updated: 2021/12/16

Matrix Scientific

Product number: 075831
Product name: 5-Bromo-2-cyano-4-methylpyridine
Purity: 95+%
Packaging: 250mg
Price: $88
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB141871
Product name: 5-Bromo-4-methylpicolinonitrile
Packaging: 500mg
Price: $140
Updated: 2021/12/16

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5-BROMO-4-METHYL-PYRIDINE-2-CARBONITRILE Chemical Properties,Usage,Production

Synthesis

773837-37-9

3430-26-0

886364-86-9

Procedure for the synthesis of 5-bromo-4-methyl-2-cyanopyridine: To a solution of 2,5-dibromo-4-methylpyridine (15 g, 59.8 mmol, 1.00 eq.) in N,N-dimethylformamide (DMF, 100 mL) was added sequentially cuprous(I) cyanide (4.28 g, 47.8 mmol, 0.8 eq.) and sodium cyanide (2.34 g, 47.8 mmol, 0.8 equiv). The reaction mixture was heated and refluxed for 20 h, during which precipitation was observed. Upon completion of the reaction, the mixture was cooled to room temperature, water (in appropriate amount) was added and sonicated to promote dispersion of the precipitate. Subsequently, the solid product was collected by filtration and washed with plenty of water to remove residual inorganic salts. The filtrate was extracted with ethyl acetate (EtOAc) and the combined organic layers were washed sequentially with water and saturated saline. The organic phase was dried over anhydrous sodium sulfate and concentrated under reduced pressure to remove the solvent to obtain the crude product. The crude product was purified by silica gel column chromatography with an eluent gradient of 0-10% ethyl acetate/hexane, and finally 5-bromo-4-methyl-pyridine-2-carbonitrile (5 g, 42.4% yield) was obtained as a white solid.

References

[1] Patent: US2013/90334, 2013, A1. Location in patent: Paragraph 0153

5-BROMO-4-METHYL-PYRIDINE-2-CARBONITRILE Preparation Products And Raw materials

Raw materials

Preparation Products

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5-BROMO-4-METHYL-PYRIDINE-2-CARBONITRILE Suppliers

China 107 India 6 Ukraine 1 United Kingdom 2 United States 15 Global 131

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View Lastest Price from 5-BROMO-4-METHYL-PYRIDINE-2-CARBONITRILE manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: 5-BROMO-4-METHYL-PYRIDINE-2-CARBONITRILE 886364-86-9
Price: US $1.10/g
Min. Order: 1g
Purity: 99.0% min
Supply Ability: 100 tons min
Release date: 2021-05-26

Henan Aochuang Chemical Co.,Ltd.

Product: 5-BROMO-4-METHYL-PYRIDINE-2-CARBONITRILE 886364-86-9
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1ton
Release date: 2022-09-29

Career Henan Chemical Co

Product: 5-BROMO-4-METHYL-PYRIDINE-2-CARBONITRILE 886364-86-9
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100KG
Release date: 2020-01-08

886364-86-9, 5-BROMO-4-METHYL-PYRIDINE-2-CARBONITRILERelated Search:

3-AMino-5-broMo-4-Methylpyridine 5-Bromo-2-pyridinecarbonitrile 2-Cyano-5-fluoropyridine 2-Cyano-4-fluoropyridine 4-CHLORO-PYRIDINE-2-CARBONITRILE 5-Bromo-6-methyl-2-pyridinecarbonitrile 2-Cyano-5-methylpyridine 4-Bromomethyl-2-cyanobiphenyl 5-broMo-4-chlorothiophene-2-carboxylic acid 5-bromo-4-trifluoromethyl-thiazole-2-ylamine 5-BroMo-4-MethoxypyriMidine 5-Bromo-4-methyl-1H-pyrrolo[2,3-b]pyridine 5-BROMO-4-METHYL-PYRIDINE-2-CARBOXYLIC ACID METHYL ESTER 5-BroMo-4-chloro-6-MethoxypyriMidine 5-BROMO-4-CHLORO-6-METHYLPYRIMIDINE 5-bromo-4-chloro-2-methylpyrimidine 5-BROMO-4-METHYL-PYRIDINE-2-CARBOXYLIC ACID 5-bromo-4-methylthiazole

5-BROMO-4-METHYL-PYRIDINE-2-CARBONITRILE

5-Bromo-2-cyano-4-methylpyridine, 5-Bromo-4-methylpicolinonitrile

5-BroMo-2-cyano-4-Methylpyridine

5-BroMo-4-Methylpicolinonitrile

5-bromo-4-methyl-2-Pyridinecarbonitrile

102106

5-Bromo-4-methylpyridine-2-carbonitrile 97%

2-Cyano-4-methyl-5-bromopyridine

5-Bromo-2-cyano-4-methyL

2-Pyridinecarbonitrile, 5-bromo-4-methyl-

5-BROMO-4-METHYL-PYRIDINE-2-CARBONITRILE ISO 9001：2015 REACH

2-CYANO-5-BROMO-4-METHYL PYRIDINE

5-Bromo-4-methyl-2-cyanopyridine

886364-86-9

Heterocycle-Pyridine series