5-broMo-4-chlorothiophene-2-carboxylic acid

Product Name: 5-broMo-4-chlorothiophene-2-carboxylic acid
CAS No.: 123418-69-9
Chemical Name: 5-broMo-4-chlorothiophene-2-carboxylic acid
Synonyms: 5-BroMo-4-chloro-2-thiophenecarboxylic acid;5-broMo-4-chlorothiophene-2-carboxylic acid;2-Thiophenecarboxylic acid, 5-bromo-4-chloro-
CBNumber: CB82606158
Molecular Formula: C5H2BrClO2S
Formula Weight: 241.49
MOL File: 123418-69-9.mol

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5-broMo-4-chlorothiophene-2-carboxylic acid Property

Boiling point:: 348.0±42.0 °C(Predicted)
Density: 2.019±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
pka: 3.31±0.10(Predicted)
Appearance: White to yellow Solid
InChI: InChI=1S/C5H2BrClO2S/c6-4-2(7)1-3(10-4)5(8)9/h1H,(H,8,9)
InChIKey: KDAAIEHVVGYWRT-UHFFFAOYSA-N
SMILES: C1(C(O)=O)SC(Br)=C(Cl)C=1

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Matrix Scientific

Product number: 297212
Product name: 5-Bromo-4-chlorothiophene-2-carboxylic acid
Packaging: 100.00mg
Price: $91
Updated: 2026/05/19

Matrix Scientific

Product number: 297212
Product name: 5-Bromo-4-chlorothiophene-2-carboxylic acid
Packaging: 250.00mg
Price: $161
Updated: 2026/05/19

Matrix Scientific

Product number: 297212
Product name: 5-Bromo-4-chlorothiophene-2-carboxylic acid
Packaging: 1.00g
Price: $339
Updated: 2026/05/19

Synthonix

Product number: B40551
Product name: 5-Bromo-4-chlorothiophene-2-carboxylic acid
Purity: 97%
Packaging: 100mg
Price: $100
Updated: 2026/05/06

Synthonix

Product number: B40551
Product name: 5-Bromo-4-chlorothiophene-2-carboxylic acid
Purity: 97%
Packaging: 250mg
Price: $170
Updated: 2026/05/06

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5-broMo-4-chlorothiophene-2-carboxylic acid Chemical Properties,Usage,Production

Synthesis

123418-66-6

123418-69-9

General procedure for the synthesis of 5-bromo-4-chlorothiophene-2-carboxylic acid from 1-(5-bromo-4-chlorothiophene-2-yl)ethanone: 1-(5-bromo-4-chlorothiophene-2-yl)ethanone (3.4 g, 14.3 mmol) was dissolved in a 1N NaOH solution (200 mL) at 0 °C, and bromine (Br2, 2.4 mL, 47.1 mmol) was slowly added dropwise. After 12 hours of reaction, the basic solution was extracted with dichloromethane (DCM). The aqueous phase was adjusted to pH 1 with hydrochloric acid and extracted several times with DCM. The organic phases were combined, dried with anhydrous sodium sulfate (Na2SO4) and concentrated under reduced pressure to give 5-bromo-4-chlorothiophene-2-carboxylic acid (1.5 g, 44% yield) as a white powder.

References

[1] Patent: WO2007/76423, 2007, A2. Location in patent: Page/Page column 142
[2] Monatshefte fuer Chemie, 1989, vol. 120, p. 53 - 63
[3] Patent: US9187472, 2015, B2. Location in patent: Page/Page column 585

5-broMo-4-chlorothiophene-2-carboxylic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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5-broMo-4-chlorothiophene-2-carboxylic acid Suppliers

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