2-Cyano-5-fluoropyridine

Product Name: 2-Cyano-5-fluoropyridine
CAS No.: 327056-62-2
Chemical Name: 2-Cyano-5-fluoropyridine
Synonyms: 5-Fluoropicolinonitrile;5-Fluoro-2-cyanopyridine;2-Cyano-5-fluorpyridine;2-Cyano-5-fluoropyridine;2-Cyano-5-fluoropyridine, 98+%;5-Fluoropyridin-2-carbonitrile;2-Carbonitrile-5-fluoropyridine;5-Fluoro-2-pyridinecarbonitrile;5-Fluoropyridine-2-carbonitrile;2-Pyridinecarbonitrile, 5-fluoro-
CBNumber: CB5969562
Molecular Formula: C6H3FN2
Formula Weight: 122.1
MOL File: 327056-62-2.mol

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2-Cyano-5-fluoropyridine Property

Melting point:: 35-41 °C
Boiling point:: 214.9±20.0 °C(Predicted)
Density: 1.24±0.1 g/cm3(Predicted)
Flash point:: 99 °C
storage temp.: Inert atmosphere,Room Temperature
solubility: soluble in Methanol
form: powder to crystal
pka: -2.74±0.10(Predicted)
color: White to Almost white
InChI: InChI=1S/C6H3FN2/c7-5-1-2-6(3-8)9-4-5/h1-2,4H
InChIKey: BHXHRMVSUUPOLX-UHFFFAOYSA-N
SMILES: C1(C#N)=NC=C(F)C=C1

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Safety

Hazard Codes: Xn,N
Risk Statements: 22-41-50/53
Safety Statements: 26-39-60-61
RIDADR: UN3439
WGK Germany: 3
HazardClass: 6.1
PackingGroup: III
HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H318Causes serious eye damage

H400Very toxic to aquatic life

Precautionary statements

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 703982
Product name: 2-Cyano-5-fluoropyridine
Purity: 97%
Packaging: 5g
Price: $69.5
Updated: 2025/07/31

Sigma-Aldrich

Product number: 703982
Product name: 2-Cyano-5-fluoropyridine
Purity: 97%
Packaging: 1g
Price: $33.4
Updated: 2023/06/20

TCI Chemical

Product number: C3286
Product name: 2-Cyano-5-fluoropyridine
Purity: >98.0%(GC)
Packaging: 1g
Price: $25
Updated: 2025/07/31

TCI Chemical

Product number: C3286
Product name: 2-Cyano-5-fluoropyridine
Purity: >98.0%(GC)
Packaging: 5g
Price: $76
Updated: 2025/07/31

TRC

Product number: F596305
Product name: 5-Fluoropyridine-2-carbonitrile
Packaging: 1g
Price: $75
Updated: 2021/12/16

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2-Cyano-5-fluoropyridine Chemical Properties,Usage,Production

Uses

5-Fluoro-2-pyridinecarbonitrile is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

Definition

ChEBI: 2-Cyano-5-fluoropyridine is a member of pyridines.

Synthesis

55338-73-3

327056-62-2

General procedure for the synthesis of 2-cyano-5-fluoropyridine from 3-amino-6-cyanopyridine: Sodium nitrite (8.7 g, 126 mmol) was added in batches to ice-salt-bath-cooled 5-amino-pyridine-2-carbonitrile (10.03 g, 84.2 mmol) dissolved in a solution of 70% hydrogen fluoride-pyridine (Aldrich, 100 g, 3.5 mol HF) ( Note: the reaction was carried out in a special reaction flask). The reaction solution was dark red in color, and after stirring in an ice-salt bath for 45 min, the ice bath was removed and the mixture continued to be stirred at room temperature for 30 min, followed by heating at 80 °C for 1.5 h. The reaction was carried out in a special reaction flask. Upon completion of the reaction, the reaction mixture was quenched by slowly pouring it into an ice/water mixture (about 400 g), extracted with dichloromethane (6 x 150 mL), the organic phase was dried over anhydrous magnesium sulfate, filtered and the solvent was concentrated under reduced pressure. The resulting crude product (10.08 g, 98% yield, orange solid) was pure enough for subsequent use and did not require further purification. The product was characterized by 1H NMR (CDCl3, 300 MHz): δ= 8.61 (d, 1H), 7.78 (m, 1H), 7.58 (m, 1H).GC-MS showed the molecular ion peak M+ 122.

References

[1] Patent: WO2005/66155, 2005, A1. Location in patent: Page/Page column 23
[2] Patent: EP1621537, 2006, A1. Location in patent: Page/Page column 57-58
[3] Patent: EP1640366, 2006, A1. Location in patent: Page/Page column 137-138
[4] Patent: EP1803719, 2007, A1. Location in patent: Page/Page column 27
[5] Patent: US2010/41717, 2010, A1. Location in patent: Page/Page column 41-42

2-Cyano-5-fluoropyridine Preparation Products And Raw materials

Raw materials

Preparation Products

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2-Cyano-5-fluoropyridine Suppliers

Americas 1 Belgium 1 China 226 Europe 2 France 1 Germany 5 India 8 Italy 1 Japan 2 Jordan 1 Switzerland 1 The Netherlands 1 United Kingdom 9 United States 41 Global 300

Fuxin Fengcheng Chemical Technology Development Co., Ltd.

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Wuhan Chemwish Technology Co., Ltd

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View Lastest Price from 2-Cyano-5-fluoropyridine manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: 2-Cyano-5-fluoropyridine 327056-62-2
Price: US $1.10/g
Min. Order: 1g
Purity: 99.0% min
Supply Ability: 100 tons min
Release date: 2021-05-13

Zhuozhou Wenxi import and Export Co., Ltd

Product: 2-Cyano-5-fluoropyridine 327056-62-2
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-11

Zhuozhou Wenxi import and Export Co., Ltd

Product: 2-Cyano-5-fluoropyridine 327056-62-2
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-09

327056-62-2, 2-Cyano-5-fluoropyridineRelated Search:

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