ChemicalBook > CAS DataBase List > 2-Cyano-5-fluoropyridine
2-Cyano-5-fluoropyridine
- Product Name
- 2-Cyano-5-fluoropyridine
- CAS No.
- 327056-62-2
- Chemical Name
- 2-Cyano-5-fluoropyridine
- Synonyms
- 5-Fluoropicolinonitrile;5-Fluoro-2-cyanopyridine;2-Cyano-5-fluorpyridine;2-Cyano-5-fluoropyridine;2-Cyano-5-fluoropyridine, 98+%;5-Fluoropyridin-2-carbonitrile;2-Carbonitrile-5-fluoropyridine;5-Fluoro-2-pyridinecarbonitrile;5-Fluoropyridine-2-carbonitrile;2-Pyridinecarbonitrile, 5-fluoro-
- CBNumber
- CB5969562
- Molecular Formula
- C6H3FN2
- Formula Weight
- 122.1
- MOL File
- 327056-62-2.mol
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2-Cyano-5-fluoropyridine Property
- Melting point:
- 35-41 °C
- Boiling point:
- 214.9±20.0 °C(Predicted)
- Density
- 1.24±0.1 g/cm3(Predicted)
- Flash point:
- 99 °C
- storage temp.
- Inert atmosphere,Room Temperature
- solubility
- soluble in Methanol
- form
- powder to crystal
- pka
- -2.74±0.10(Predicted)
- color
- White to Almost white
- InChI
- InChI=1S/C6H3FN2/c7-5-1-2-6(3-8)9-4-5/h1-2,4H
- InChIKey
- BHXHRMVSUUPOLX-UHFFFAOYSA-N
- SMILES
- C1(C#N)=NC=C(F)C=C1
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Safety
- Hazard Codes
- Xn,N
- Risk Statements
- 22-41-50/53
- Safety Statements
- 26-39-60-61
- RIDADR
- UN3439
- WGK Germany
- 3
- HazardClass
- 6.1
- PackingGroup
- III
- HS Code
- 2933399990
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H302Harmful if swallowed
H318Causes serious eye damage
H400Very toxic to aquatic life
- Precautionary statements
-
P273Avoid release to the environment.
P280Wear protective gloves/protective clothing/eye protection/face protection.
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N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- 703982
- Product name
- 2-Cyano-5-fluoropyridine
- Purity
- 97%
- Packaging
- 5g
- Price
- $69.5
- Updated
- 2025/07/31
Sigma-Aldrich
- Product number
- 703982
- Product name
- 2-Cyano-5-fluoropyridine
- Purity
- 97%
- Packaging
- 1g
- Price
- $33.4
- Updated
- 2023/06/20
TCI Chemical
- Product number
- C3286
- Product name
- 2-Cyano-5-fluoropyridine
- Purity
- >98.0%(GC)
- Packaging
- 1g
- Price
- $25
- Updated
- 2025/07/31
TCI Chemical
- Product number
- C3286
- Product name
- 2-Cyano-5-fluoropyridine
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $76
- Updated
- 2025/07/31
TRC
- Product number
- F596305
- Product name
- 5-Fluoropyridine-2-carbonitrile
- Packaging
- 1g
- Price
- $75
- Updated
- 2021/12/16
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2-Cyano-5-fluoropyridine Chemical Properties,Usage,Production
Uses
5-Fluoro-2-pyridinecarbonitrile is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
Definition
ChEBI: 2-Cyano-5-fluoropyridine is a member of pyridines.
Synthesis
55338-73-3
327056-62-2
General procedure for the synthesis of 2-cyano-5-fluoropyridine from 3-amino-6-cyanopyridine: Sodium nitrite (8.7 g, 126 mmol) was added in batches to ice-salt-bath-cooled 5-amino-pyridine-2-carbonitrile (10.03 g, 84.2 mmol) dissolved in a solution of 70% hydrogen fluoride-pyridine (Aldrich, 100 g, 3.5 mol HF) ( Note: the reaction was carried out in a special reaction flask). The reaction solution was dark red in color, and after stirring in an ice-salt bath for 45 min, the ice bath was removed and the mixture continued to be stirred at room temperature for 30 min, followed by heating at 80 °C for 1.5 h. The reaction was carried out in a special reaction flask. Upon completion of the reaction, the reaction mixture was quenched by slowly pouring it into an ice/water mixture (about 400 g), extracted with dichloromethane (6 x 150 mL), the organic phase was dried over anhydrous magnesium sulfate, filtered and the solvent was concentrated under reduced pressure. The resulting crude product (10.08 g, 98% yield, orange solid) was pure enough for subsequent use and did not require further purification. The product was characterized by 1H NMR (CDCl3, 300 MHz): δ= 8.61 (d, 1H), 7.78 (m, 1H), 7.58 (m, 1H).GC-MS showed the molecular ion peak M+ 122.
References
[1] Patent: WO2005/66155, 2005, A1. Location in patent: Page/Page column 23
[2] Patent: EP1621537, 2006, A1. Location in patent: Page/Page column 57-58
[3] Patent: EP1640366, 2006, A1. Location in patent: Page/Page column 137-138
[4] Patent: EP1803719, 2007, A1. Location in patent: Page/Page column 27
[5] Patent: US2010/41717, 2010, A1. Location in patent: Page/Page column 41-42
2-Cyano-5-fluoropyridine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-Cyano-5-fluoropyridine manufacturers
Shaanxi Dideu Medichem Co. Ltd
- Product
- 2-Cyano-5-fluoropyridine 327056-62-2
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.0% min
- Supply Ability
- 100 tons min
- Release date
- 2021-05-13
Zhuozhou Wenxi import and Export Co., Ltd
- Product
- 2-Cyano-5-fluoropyridine 327056-62-2
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-11
Zhuozhou Wenxi import and Export Co., Ltd
- Product
- 2-Cyano-5-fluoropyridine 327056-62-2
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-09
327056-62-2, 2-Cyano-5-fluoropyridineRelated Search:
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