Divalproex sodium
- Product Name
- Divalproex sodium
- CAS No.
- 76584-70-8
- Chemical Name
- Divalproex sodium
- Synonyms
- Epival;6584-70-8;DIVALPROEX SODIUM;Sodium salt (2:1);SODIUM DIVALPROATE;Divalpropex Sodium;SEMISODIUMVALPROATE;Valproate semisodium;Divalproex (sodium salt);Divalproex Sodium (200 mg)
- CBNumber
- CB4149527
- Molecular Formula
- C8H17NaO2
- Formula Weight
- 168.21
- MOL File
- 76584-70-8.mol
Divalproex sodium Property
- Melting point:
- 222 °C
- storage temp.
- Inert atmosphere,2-8°C
- solubility
- Chloroform (Slightly), Methanol (Slightly)
- form
- Solid
- color
- White
- CAS DataBase Reference
- 76584-70-8(CAS DataBase Reference)
Safety
- HS Code
- 2915900000
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H228Flammable solid
- Precautionary statements
-
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P240Ground/bond container and receiving equipment.
P241Use explosion-proof electrical/ventilating/lighting/…/equipment.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P370+P378In case of fire: Use … for extinction.
N-Bromosuccinimide Price
- Product number
- 22960
- Product name
- Divalproex (sodium salt)
- Purity
- ≥95%
- Packaging
- 50g
- Price
- $158
- Updated
- 2024/03/01
- Product number
- 22960
- Product name
- Divalproex (sodium salt)
- Purity
- ≥95%
- Packaging
- 100g
- Price
- $267
- Updated
- 2024/03/01
- Product number
- V094755
- Product name
- ValproicAcidSemisodiumSalt
- Packaging
- 50mg
- Price
- $50
- Updated
- 2021/12/16
- Product number
- B1391
- Product name
- DivalproexSodium
- Packaging
- 10mM(in 1mL DMSO)
- Price
- $50
- Updated
- 2021/12/16
- Product number
- B1391
- Product name
- DivalproexSodium
- Packaging
- 1unit
- Price
- $28
- Updated
- 2021/12/16
Divalproex sodium Chemical Properties,Usage,Production
Description
Divalproex is a prodrug form of valproic acid that contains valproic acid and valproate sodium. Formulations containing divalproex exhibit delayed gastrointestinal absorption and are converted to valproic acid in the intestine, which reduces gastric irritation and nervous system side effects. Formulations containing divalproex are widely used for the treatment of seizures and bipolar disorder.
Chemical Properties
White Solid
Originator
Depakote,Abbott
Uses
Antiepileptic; Anticonvulsant that also acts as a mood stabilizer for those with bipolar disorder.
Uses
Divalproex sodium consists of a compound of sodium valproate and valproic acid in a 1:1 molar relationship in an enteric coated form. In rare cases, it is also used as a treatment for major depressive disorder, and increasingly taken long-term for prevent
Uses
Anticonvulsant; Bipolar Agent
Definition
ChEBI: A mixture of valproic acid and its sodium salt in a 1:1 molar ratio. It is used for the management and treatment of seizure disorders, mania, and prophylactic treatment of migraine headache.
Manufacturing Process
Dipropyl acetic acid or valproic acid may be prepared the next way.
Propylbromide is mixed with cyanacetic acid in the presence of sodium
ethylate, made from absolute ethanol and sodium. By that prepared α,α-
dipropylcyanacetic acid ethyl ester is saponified with equimolecular amounts
of NaOH to give dipropylacetonitril. The desired dipropylacetic acid is produced
by saponification of dipropylacetonitryl with aquatic NaOH. It is colorless
liquid. BP 219°-220°C.
Sodium salt of this acid may be prepared by adding of equivalent of NaOH.
brand name
Depakote (Abbott）.
Therapeutic Function
Anticonvulsant
Clinical Use
Treatment of manic episodes associated with bipolar disorder
Migraine prophylaxis (unlicensed)
Drug interactions
Potentially hazardous interactions with other drugs
Antibacterials: metabolism possibly inhibited
by erythromycin; avoid with pivmecillinam;
concentration reduced by carbapenems - avoid.
Antidepressants: avoid with St John’s wort.
Antiepileptics: concentration reduced by
carbamazepine; concentration of active
carbamazepine metabolite increased; increased
concentration of lamotrigine, phenobarbital,
rufinamide and possibly ethosuximide; sometimes
reduces concentration of active metabolite of
oxcarbazepine; alters phenytoin concentration;
phenytoin and phenobarbital reduce valproate
concentration; hyperammonaemia and CNS toxicity
with topiramate.
Antipsychotics: increased neutropenia with
olanzapine; possibly increases or decreases
concentration of clozapine; possibly increases
quetiapine concentration.
Ciclosporin: variable ciclosporin blood level response.
Sodium oxybate: concentration of sodium oxybate
increased.
Ulcer-healing drugs: metabolism inhibited by
cimetidine, increased concentration.
Metabolism
Valproic acid is extensively metabolised in the liver, a large
part by glucuronidation (up to 60
%) and the rest by a
variety of complex pathways (up to 45
%). It is excreted in
the urine almost entirely in the form of its metabolites;
small amounts are excreted in faeces and expired air.
Divalproex sodium Preparation Products And Raw materials
Raw materials
Preparation Products
Divalproex sodium Suppliers
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- Country
- France
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- France
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View Lastest Price from Divalproex sodium manufacturers
- Product
- Divalproex sodium 76584-70-8
- Price
- US $10.00/KG
- Min. Order
- 25Kg/Drum
- Purity
- 99.99%
- Supply Ability
- 20 tons/month
- Release date
- 2021-04-20
- Product
- Divalproex sodium 76584-70-8
- Price
- US $1.00/KG
- Min. Order
- 1G
- Purity
- 98%
- Supply Ability
- 100KG
- Release date
- 2018-08-20