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Divalproex sodium

Product Name
Divalproex sodium
CAS No.
76584-70-8
Chemical Name
Divalproex sodium
Synonyms
Epival;6584-70-8;DIVALPROEX SODIUM;Sodium salt (2:1);SODIUM DIVALPROATE;Divalpropex Sodium;SEMISODIUMVALPROATE;Valproate semisodium;Divalproex (sodium salt);Divalproex Sodium (200 mg)
CBNumber
CB4149527
Molecular Formula
C8H17NaO2
Formula Weight
168.21
MOL File
76584-70-8.mol
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Divalproex sodium Property

Melting point:
222 °C
storage temp. 
Inert atmosphere,2-8°C
solubility 
Chloroform (Slightly), Methanol (Slightly)
form 
Solid
color 
White
CAS DataBase Reference
76584-70-8(CAS DataBase Reference)
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Safety

HS Code 
2915900000
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H228Flammable solid

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P240Ground/bond container and receiving equipment.

P241Use explosion-proof electrical/ventilating/lighting/…/equipment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P370+P378In case of fire: Use … for extinction.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
22960
Product name
Divalproex (sodium salt)
Purity
≥95%
Packaging
50g
Price
$158
Updated
2024/03/01
Cayman Chemical
Product number
22960
Product name
Divalproex (sodium salt)
Purity
≥95%
Packaging
100g
Price
$267
Updated
2024/03/01
TRC
Product number
V094755
Product name
ValproicAcidSemisodiumSalt
Packaging
50mg
Price
$50
Updated
2021/12/16
ApexBio Technology
Product number
B1391
Product name
DivalproexSodium
Packaging
1unit
Price
$28
Updated
2021/12/16
ApexBio Technology
Product number
B1391
Product name
DivalproexSodium
Packaging
10mM(in 1mL DMSO)
Price
$50
Updated
2021/12/16
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Divalproex sodium Chemical Properties,Usage,Production

Description

Divalproex is a prodrug form of valproic acid that contains valproic acid and valproate sodium. Formulations containing divalproex exhibit delayed gastrointestinal absorption and are converted to valproic acid in the intestine, which reduces gastric irritation and nervous system side effects. Formulations containing divalproex are widely used for the treatment of seizures and bipolar disorder.

Chemical Properties

White Solid

Originator

Depakote,Abbott

Uses

Antiepileptic; Anticonvulsant that also acts as a mood stabilizer for those with bipolar disorder.

Uses

Divalproex sodium consists of a compound of sodium valproate and valproic acid in a 1:1 molar relationship in an enteric coated form. In rare cases, it is also used as a treatment for major depressive disorder, and increasingly taken long-term for prevent

Uses

Anticonvulsant; Bipolar Agent

Definition

ChEBI: A mixture of valproic acid and its sodium salt in a 1:1 molar ratio. It is used for the management and treatment of seizure disorders, mania, and prophylactic treatment of migraine headache.

Manufacturing Process

Dipropyl acetic acid or valproic acid may be prepared the next way. Propylbromide is mixed with cyanacetic acid in the presence of sodium ethylate, made from absolute ethanol and sodium. By that prepared α,α- dipropylcyanacetic acid ethyl ester is saponified with equimolecular amounts of NaOH to give dipropylacetonitril. The desired dipropylacetic acid is produced by saponification of dipropylacetonitryl with aquatic NaOH. It is colorless liquid. BP 219°-220°C.
Sodium salt of this acid may be prepared by adding of equivalent of NaOH.

brand name

Depakote (Abbott）.

Therapeutic Function

Anticonvulsant

Clinical Use


Treatment of manic episodes associated with bipolar disorder
Migraine prophylaxis (unlicensed)

Drug interactions

Potentially hazardous interactions with other drugs
Antibacterials: metabolism possibly inhibited by erythromycin; avoid with pivmecillinam; concentration reduced by carbapenems - avoid.
Antidepressants: avoid with St John’s wort.
Antiepileptics: concentration reduced by carbamazepine; concentration of active carbamazepine metabolite increased; increased concentration of lamotrigine, phenobarbital, rufinamide and possibly ethosuximide; sometimes reduces concentration of active metabolite of oxcarbazepine; alters phenytoin concentration; phenytoin and phenobarbital reduce valproate concentration; hyperammonaemia and CNS toxicity with topiramate.
Antipsychotics: increased neutropenia with olanzapine; possibly increases or decreases concentration of clozapine; possibly increases quetiapine concentration.
Ciclosporin: variable ciclosporin blood level response.
Sodium oxybate: concentration of sodium oxybate increased.
Ulcer-healing drugs: metabolism inhibited by cimetidine, increased concentration.

Metabolism

Valproic acid is extensively metabolised in the liver, a large part by glucuronidation (up to 60
%) and the rest by a variety of complex pathways (up to 45
%). It is excreted in the urine almost entirely in the form of its metabolites; small amounts are excreted in faeces and expired air.

Divalproex sodium Preparation Products And Raw materials

Raw materials

Preparation Products

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Divalproex sodium Suppliers

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View Lastest Price from Divalproex sodium manufacturers

Wuhan Monad Medicine Tech Co.,LTD
Product
Divalproex sodium 76584-70-8
Price
US $10.00/KG
Min. Order
25Kg/Drum
Purity
99.99%
Supply Ability
20 tons/month
Release date
2021-04-20
Career Henan Chemical Co
Product
Divalproex sodium 76584-70-8
Price
US $1.00/KG
Min. Order
1G
Purity
98%
Supply Ability
100KG
Release date
2018-08-20

76584-70-8, Divalproex sodiumRelated Search:

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