ChemicalBook > CAS DataBase List > 6-BROMO-BENZO[B]THIOPHENE-2-CARBOXY LIC ACID METHYL ESTER

6-BROMO-BENZO[B]THIOPHENE-2-CARBOXY LIC ACID METHYL ESTER

Product Name
6-BROMO-BENZO[B]THIOPHENE-2-CARBOXY LIC ACID METHYL ESTER
CAS No.
360576-01-8
Chemical Name
6-BROMO-BENZO[B]THIOPHENE-2-CARBOXY LIC ACID METHYL ESTER
Synonyms
6-bromo-benzo[b]thiophene-2-carboxyL;Methyl 6-BroMobenzo[b]thiophene-2-carboxy;Methyl 6-Bromobenzothiophene-2-carboxylate;Piperazine,1-(3-chlorophenyl)-,hydrochloride(1:4);6-BroMobenzothiophene-2-carboxylic Acid Methyl Ester;6-BroMo-1-benzothiophene-2-carboxylic Acid Methyl Ester;Benzo[b]thiophene-2-carboxylic acid, 6-bromo-, methyl ester;Methyl 6-bromo-1-benzothiophene-2-carboxylate, 6-Bromo-2-(methoxycarbonyl)benzo[b]thiophene
CBNumber
CB41501762
Molecular Formula
C10H7BrO2S
Formula Weight
271.13
MOL File
360576-01-8.mol
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6-BROMO-BENZO[B]THIOPHENE-2-CARBOXY LIC ACID METHYL ESTER Property

Melting point:
117-119°
Boiling point:
358.9±22.0 °C(Predicted)
Density 
1.622±0.06 g/cm3(Predicted)
storage temp. 
2-8°C(protect from light)
form 
powder
color 
Off-white
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Safety

HazardClass 
IRRITANT
HS Code 
2934999090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TRC
Product number
B680265
Product name
6-Bromobenzothiophene-2-carboxylicAcidMethylEster
Packaging
5g
Price
$305
Updated
2021/12/16
Usbiological
Product number
004638
Product name
6-Bromobenzothiophene-2-carboxylic Acid Methyl Ester
Packaging
1g
Price
$460
Updated
2021/12/16
Matrix Scientific
Product number
047910
Product name
Methyl 6-bromo-1-benzothiophene-2-carboxylate
Purity
>95%
Packaging
5g
Price
$319
Updated
2021/12/16
SynQuest Laboratories
Product number
6H66-9-Y0
Product name
Methyl 6-bromobenzo[b]thiophene-2-carboxylate
Packaging
1g
Price
$42
Updated
2021/12/16
Matrix Scientific
Product number
047910
Product name
Methyl 6-bromo-1-benzothiophene-2-carboxylate
Purity
>95%
Packaging
500mg
Price
$60
Updated
2021/12/16
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6-BROMO-BENZO[B]THIOPHENE-2-CARBOXY LIC ACID METHYL ESTER Chemical Properties,Usage,Production

Uses

6-Bromobenzo[b]thiophene-2-carboxylic acid methyl ester is used in the synthesis of benzothiophene derivatives as histone deacetylase inhibitors.

Synthesis

2365-48-2

57848-46-1

360576-01-8

GENERAL METHOD: Compound 1a or 1b (9.90 mmol) was dissolved in DMF (20 mL) under stirring conditions, followed by the sequential addition of methyl mercaptoacetate (10.9 mmol) and potassium carbonate (39.6 mmol). The reaction mixture was stirred continuously at 60 °C for 15 hours. After completion of the reaction, the DMF solvent was removed by distillation under reduced pressure. Water (50 mL) was added to the residue, which was then extracted with ethyl acetate (2 x 40 mL). The organic phases were combined, dried with anhydrous sodium sulfate, filtered, and the solvent was removed by reduced pressure distillation to give the final target product, methyl 6-bromobenzo[b]thiophene-2-carboxylate (2a or 2b).

References

[1] European Journal of Medicinal Chemistry, 2017, vol. 125, p. 538 - 550
[2] Patent: WO2012/149413, 2012, A1. Location in patent: Page/Page column 58
[3] Journal of Medicinal Chemistry, 2016, vol. 59, # 1, p. 264 - 281
[4] Journal of Medicinal Chemistry, 2015, vol. 58, # 18, p. 7241 - 7257
[5] Patent: JP2015/89879, 2015, A. Location in patent: Paragraph 0016; 0047; 0048

6-BROMO-BENZO[B]THIOPHENE-2-CARBOXY LIC ACID METHYL ESTER Preparation Products And Raw materials

Raw materials

Preparation Products

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6-BROMO-BENZO[B]THIOPHENE-2-CARBOXY LIC ACID METHYL ESTER Suppliers

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View Lastest Price from 6-BROMO-BENZO[B]THIOPHENE-2-CARBOXY LIC ACID METHYL ESTER manufacturers

Career Henan Chemical Co
Product
6-BROMO-BENZO[B]THIOPHENE-2-CARBOXY LIC ACID METHYL ESTER 360576-01-8
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
200kg
Release date
2020-01-02

360576-01-8, 6-BROMO-BENZO[B]THIOPHENE-2-CARBOXY LIC ACID METHYL ESTERRelated Search:

6-BROMO-1-METHYL-1H-INDAZOLE 6-BROMO-2H-1,4-BENZOXAZIN-3(4H)-ONE 1H-Pyrido[4,3-b]indole, 6-bromo-2,3,4,5-tetrahydro-, hydrochloride (1:1) Methyl 6-bromo-1-methyl-1... 6-BROMOISOQUINOLIN-1-YLAMINE 6-Bromo-2-trifluoromethyl-3H-imidazo[4,5-b]pyridine 6-Bromo-2-(chloromethyl)imidazo[1,2-a]pyrimidine 6-Bromo-2,3-Dihydroquinolin-4(1H)-One 6-BROMO-2,3-DIMETHOXY-BENZALDEHYDE 6-BROMO-2(1H)-QUINAZOLINONE 6-bromo-2,3,4,9-tetrahydro-1H-carbazole Methyl 6-broMo-2,3-diMethoxybenzoate 6-BroMo-2,3,4,5-tetrahydro-1H-benzo[b]azepine 6-BROMO-BENZO[B]THIOPHENE-2-CARBOXYLIC ACID 6-BROMO-BENZO[B]THIOPHENE Methyl 6-bromo-2-naphthoate methyl 6-bromo-3-fluoro-2-methylbenzoate methyl 6-bromo-2-methylnicotinate

  • Methyl 6-bromo-1-benzothiophene-2-carboxylate, 6-Bromo-2-(methoxycarbonyl)benzo[b]thiophene
  • 6-BroMo-1-benzothiophene-2-carboxylic Acid Methyl Ester
  • 6-BroMobenzothiophene-2-carboxylic Acid Methyl Ester
  • Methyl 6-BroMobenzo[b]thiophene-2-carboxy
  • 6-bromo-benzo[b]thiophene-2-carboxyL
  • Benzo[b]thiophene-2-carboxylic acid, 6-bromo-, methyl ester
  • Piperazine,1-(3-chlorophenyl)-,hydrochloride(1:4)
  • Methyl 6-Bromobenzothiophene-2-carboxylate
  • 360576-01-8
  • Others ,Pyridazines