3-AMINO-1,2-PHTHALIC ACID, DIMETHYL ESTER
Uses- Product Name
- 3-AMINO-1,2-PHTHALIC ACID, DIMETHYL ESTER
- CAS No.
- 34529-06-1
- Chemical Name
- 3-AMINO-1,2-PHTHALIC ACID, DIMETHYL ESTER
- Synonyms
- MFCD16293748;Apster Impurity 75.;dimethyl 3-aminophthalate;Sitagliptin Impurity 37-d3;dimethyl 3-aminobenzene-1,2-dioate;3-Amino-phthalic acid dimethyl ester;dimethyl 3-aminobenzene-1,2-dicarboxylate;3-AMINO-1,2-PHTHALIC ACID, DIMETHYL ESTER;DiMethyl 3-aMino-1,2-benzenedicarboxylate;Methyl 3-amino-2-(methoxycarbonyl)benzoate
- CBNumber
- CB41502628
- Molecular Formula
- C10H11NO4
- Formula Weight
- 209.2
- MOL File
- 34529-06-1.mol
3-AMINO-1,2-PHTHALIC ACID, DIMETHYL ESTER Property
- Boiling point:
- 306℃
- Density
- 1.248
- Flash point:
- 136℃
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- pka
- 1.05±0.10(Predicted)
- Appearance
- Off-white to yellow Solid-Liquid Mixture
Safety
- HS Code
- 2921420090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- D492838
- Product name
- Dimethyl3-Aminophthalate
- Packaging
- 100mg
- Price
- $75
- Updated
- 2021/12/16
- Product number
- 112863
- Product name
- Dimethyl 3-amino-1,2-benzenedicarboxylate
- Packaging
- 1g
- Price
- $44
- Updated
- 2021/12/16
- Product number
- 4H58-1-8R
- Product name
- Dimethyl 3-amino-1,2-benzenedicarboxylate
- Packaging
- 1g
- Price
- $75
- Updated
- 2021/12/16
- Product number
- FD133109
- Product name
- Dimethyl 3-aminophthalate hydrochloride
- Packaging
- 250mg
- Price
- $85
- Updated
- 2021/12/16
- Product number
- 4H58-1-8R
- Product name
- Dimethyl 3-amino-1,2-benzenedicarboxylate
- Packaging
- 5G
- Price
- $125
- Updated
- 2021/12/16
3-AMINO-1,2-PHTHALIC ACID, DIMETHYL ESTER Chemical Properties,Usage,Production
Uses
Dimethyl 3-aminophthalate is a useful research chemical.
Synthesis
13365-26-9
34529-06-1
The general procedure for the synthesis of dimethyl 3-amino-phthalate from methyl 3-nitrophthalate was as follows: first, methyl 3-nitrophthalate was converted to the corresponding chloride by a chlorination reaction, followed by esterification to obtain dimethyl 3-nitrophthalate (100% yield). Next, the nitro group was reduced to an amino group by catalytic hydrogenation to obtain dimethyl 3-amino-phthalate (100% yield). Subsequently, diazotization of the amino group was followed by iodination to obtain dimethyl 3-iodophthalate (about 91% yield). Then, a saponification reaction was carried out on dimethyl 3-iodophthalate, followed by acidification to obtain 3-iodophthalic acid (yield about 93%). Finally, 3-iodophthalic acid was oxidized and reacted in the presence of KBrO3 and 0.73 M H2SO4 at 55-60 °C for 12 h to obtain water-soluble MIBX.Upon completion of the reaction, purification by evaporation, cooled milling and filtration yielded white solid MIBX (~70% yield, melting point 258-260 °C). The conversion of the process is nearly quantitative and can be monitored by 1H NMR spectroscopy.The physical properties of MIBX include IR (KBr) showing characteristic absorption peaks; 1H NMR (D2O, 300 MHz) and 13C NMR (D2O, 75 MHz) showing specific chemical shifts.
References
[1] Journal of Heterocyclic Chemistry, 1989, vol. 26, # 6, p. 1885 - 1886
[2] Tetrahedron Letters, 2002, vol. 43, # 4, p. 569 - 572
[3] Patent: US2004/30187, 2004, A1. Location in patent: Page 2; Sheet 1
[4] RSC Advances, 2015, vol. 5, # 60, p. 48861 - 48867
[5] Bioorganic and Medicinal Chemistry Letters, 2008, vol. 18, # 1, p. 285 - 288
3-AMINO-1,2-PHTHALIC ACID, DIMETHYL ESTER Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 3-AMINO-1,2-PHTHALIC ACID, DIMETHYL ESTER manufacturers
- Product
- Dimethyl 3-aminophthalate 34529-06-1
- Price
- US $139.50/Kg/Drum
- Min. Order
- 25Kg/Drum
- Purity
- 98.00%HPLC
- Supply Ability
- 5tons/month
- Release date
- 2021-09-18
- Product
- 3-AMINO-1,2-PHTHALIC ACID, DIMETHYL ESTER 34529-06-1
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 95-99%
- Supply Ability
- 1ton
- Release date
- 2020-01-03