2-(3-Hydroxy-1-phenylpropyl)-4-methylphenol
- Product Name
- 2-(3-Hydroxy-1-phenylpropyl)-4-methylphenol
- CAS No.
- 851789-43-0
- Chemical Name
- 2-(3-Hydroxy-1-phenylpropyl)-4-methylphenol
- Synonyms
- DI HYDROXY IMPURITY;Tolterodine impurity Z12;Tolterodine diol impurit;Tolterodine Propanol Analog;2-Hydroxy-5-methyl-γ-phenylbenzenepropanol;2-(3-Hydroxy-1-phenylpropyl)-4-methylphenol;2-(3-Hydro-1-phenyl-propyl)-4-methyl-phenol;3-(2-Hydroxy-5-methylphenyl)-3-phenylpropanol;Benzenepropanol, 2-hydroxy-5-methyl-γ-phenyl-;2-Hydroxy-5-methyl-gamma-phenylbenzenepropanol
- CBNumber
- CB41503089
- Molecular Formula
- C16H18O2
- Formula Weight
- 242.31
- MOL File
- 851789-43-0.mol
2-(3-Hydroxy-1-phenylpropyl)-4-methylphenol Property
- Melting point:
- 118-120°C
- Boiling point:
- 414.8±40.0 °C(Predicted)
- Density
- 1.128
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- Chloroform (Slightly), Methanol (Slightly)
- form
- Solid
- pka
- 10.18±0.48(Predicted)
- color
- White to Off-White
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- H948185
- Product name
- 2-Hydroxy-5-methyl-γ-phenylbenzenepropanol(TolterodineImpurity)
- Packaging
- 1g
- Price
- $525
- Updated
- 2021/12/16
- Product number
- H948185
- Product name
- 2-Hydroxy-5-methyl-γ-phenylbenzenepropanol(TolterodineImpurity)
- Packaging
- 2.5g
- Price
- $1190
- Updated
- 2021/12/16
- Product number
- IH24280
- Product name
- 2-Hydroxy-5-methyl-gamma-phenylbenzenepropanol
- Packaging
- 100mg
- Price
- $122
- Updated
- 2021/12/16
- Product number
- IH24280
- Product name
- 2-Hydroxy-5-methyl-gamma-phenylbenzenepropanol
- Packaging
- 250mg
- Price
- $222.5
- Updated
- 2021/12/16
- Product number
- IH24280
- Product name
- 2-Hydroxy-5-methyl-gamma-phenylbenzenepropanol
- Packaging
- 500mg
- Price
- $400
- Updated
- 2021/12/16
2-(3-Hydroxy-1-phenylpropyl)-4-methylphenol Chemical Properties,Usage,Production
Chemical Properties
2-(3-Hydroxy-1-phenylpropyl)-4-methylphenol is White Solid
Uses
Tolterodine (T535800) impurity. Used in the efficient synthesis of Tolterodine.
Uses
2-(3-Hydroxy-1-phenylpropyl)-4-methylphenol is used in the efficient synthesis of Tolterodine.
Synthesis
40546-94-9
851789-43-0
GENERAL STEPS: A solution of 7-methyl-4-phenyl-3,4-dihydrocoumarin (9.52 g, 40.0 mmol) in anhydrous tetrahydrofuran (50 mL) was added slowly and dropwise to a suspension of lithium aluminium hydride (3.04 g, 80 mmol) in anhydrous tetrahydrofuran (100 mL) cooled to 0 °C. The reaction mixture was stirred at room temperature and under inert atmosphere for 1 hour. Subsequently, 50 mL of a 1:1 mixture of tetrahydrofuran and water was added cautiously and acidified with 1 mol/L hydrochloric acid solution (150 mL) to quench the reaction. The reaction product was extracted with ethyl acetate and the organic phases were combined, washed sequentially with water and brine and dried over anhydrous magnesium sulfate. After removing the solvent under reduced pressure, 2-(3-hydroxy-1-phenylpropyl)-4-methylphenol (compound of formula II) was obtained in 97% yield (9.68 g). The product was recrystallized by diisopropyl ether to obtain a white powder. Melting point: 112-115 °C. 1H NMR (300 MHz, DMSO-d6): δ [ppm] = 2.08-2.17 (5H, m, CH3, CH2), 3.29-3.31 (2H, m, CH2), 4.38, 4.42 (2H, 2 xt, CH, OH), 6.63 (1H, d, J = 8.0 Hz, 1H- Ar), 6.76 (1H, dd, J = 8.3, 1.7 Hz, 1H-Ar), 7.00 (1H, d, J = 1.7 Hz, 1H-Ar), 7.08-7.13 (2H, m, 1H-Ph), 7.20-7.28 (3H, m, 4H-Ph), 9.04 (1H, s, OH). 13C NMR (300 MHz, DMSO-d6): δ [ppm] 20.5, 37.6, 39.1, 59.3, 115.0, 125.6, 127.0, 127.3, 127.9, 128.0, 130.9, 145.3, 152.4. ESI-MS: 243 [M + H]+.
References
[1] Patent: WO2006/66931, 2006, A1. Location in patent: Page/Page column 17
[2] Asian Journal of Chemistry, 2014, vol. 26, # 9, p. 2813 - 2814
[3] Tetrahedron Letters, 2008, vol. 49, # 23, p. 3790 - 3793
[4] Patent: US2006/79716, 2006, A1. Location in patent: Page/Page column 7
[5] Journal of Heterocyclic Chemistry, 2018, vol. 55, # 9, p. 2157 - 2167
2-(3-Hydroxy-1-phenylpropyl)-4-methylphenol Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-(3-Hydroxy-1-phenylpropyl)-4-methylphenol manufacturers
- Product
- 2-(3-Hydroxy-1-phenylpropyl)-4-methylphenol 851789-43-0
- Price
- US $374.00/g
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 500ton/Month
- Release date
- 2021-12-21