avosentan

Product Name: avosentan
CAS No.: 290815-26-8
Chemical Name: avosentan
Synonyms: CS-644;SPP-301;avosentan;Ro 67-0565;Avosentan (SPP301);RO 67-0565; SPP-301;Avosentan (Ro 67-0565;avosentan,CID 9912992;inhibit,SPP 301,Inhibitor,Avosentan,SPP301,Endothelin Receptor;N-(6-Methoxy-5-(2-methoxyphenoxy)-2-(pyridin-4-yl)-pyrimidin-4-yl)-5-methylpyridine-2-sulfonam
CBNumber: CB41508589
Molecular Formula: C23H21N5O5S
Formula Weight: 479.51
MOL File: 290815-26-8.mol

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avosentan Property

Boiling point:: 575.5±60.0 °C(Predicted)
Density: 1.363
storage temp.: Store at -20°C
solubility: DMSO : 6.67 mg/mL (13.91 mM; Need ultrasonic)H2O : < 0.1 mg/mL (insoluble)
form: Powder
pka: 3.19±0.10(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC

Product number: A794710
Product name: Avosentan
Packaging: 10mg
Price: $165
Updated: 2021/12/16

Usbiological

Product number: 002983
Product name: Avosentan
Packaging: 10mg
Price: $460
Updated: 2021/12/16

ChemScene

Product number: CS-0625
Product name: Avosentan
Purity: 98.36%
Packaging: 10mg
Price: $180
Updated: 2021/12/16

Matrix Scientific

Product number: 098678
Product name: N-(6-Methoxy-5-(2-methoxyphenoxy)-2-(pyridin-4-yl)-pyrimidin-4-yl)-5-methylpyridine-2-sulfonamide
Purity: 95+%
Packaging: 250mg
Price: $742
Updated: 2021/12/16

ChemScene

Product number: CS-0625
Product name: Avosentan
Purity: 98.36%
Packaging: 50mg
Price: $840
Updated: 2021/12/16

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avosentan Chemical Properties,Usage,Production

Uses

Avosentan is a competitive antagonist of Endothelin-1 (ET-1) with a high selectivity for the ETA receptor. Avosentan may be a potential option in the treatment of glaucoma.

Enzyme inhibitor

This potent, selective and orally available endothelin A receptor blocker (FW = 479.51 g/mol; CAS 290815-26-8; Soluble in DMSO), also known by its code names SPP301 and Ro 67-0565, induces the dose-dependent reduction in the fractional renal excretion of sodium (up to 8.7% at 50 mg avosentan), with a paralleled dose-related increase in proximal sodium reabsorption. Avosentan reduces albuminuria, when added to standard treatment in patients with type 2 diabetes and overt nephropathy, but induces significant fluid overload and congestive heart failure.

avosentan Preparation Products And Raw materials

Raw materials

Preparation Products

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avosentan Suppliers

Canada 1 China 56 India 2 United States 11 Global 70

LGM Pharma

Tel: 1-(800)-881-8210
Fax: 615-250-9817
Email: inquiries@lgmpharma.com
Country: United States
ProdList: 2123
Advantage: 70

MedChemexpress LLC

Tel: 021-58955995
Fax: 609-228-5909
Email: sales@medchemexpress.cn
Country: United States
ProdList: 4861
Advantage: 58

AdooQ BioScience, LLC

Tel: +1 (866) 930-6790
Fax: +1 (866) 333-9607
Email: info@adooq.com
Country: United States
ProdList: 2782
Advantage: 58

Musechem

Tel: +1-800-259-7612
Fax: +1-800-259-7612
Email: info@musechem.com
Country: United States
ProdList: 4660
Advantage: 60

Cckinase, Inc.

Tel: +1 (732)236-3202
Email: sales@cckinase.com
Country: United States
ProdList: 2738
Advantage: 58

TargetMol Chemicals Inc.

Tel
Email: support@targetmol.com
Country: United States
ProdList: 38631
Advantage: 58

Aladdin Scientific

Tel: +1-+1(833)-552-7181
Email: sales@aladdinsci.com
Country: United States
ProdList: 52924
Advantage: 58

ApexBio Technology

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Email: sales@apexbt.com
Country: United States
ProdList: 6251
Advantage: 58

United States Biological

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Email: chemicals@usbio.net
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ProdList: 6214
Advantage: 80

MedChemExpress

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Email: sales@medchemexpress.com
Country: United States
ProdList: 6398
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Matrix Scientific

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Email: sales@matrixscientific.com
Country: United States
ProdList: 6632
Advantage: 80

290815-26-8, avosentanRelated Search:

p-Anisidine 5-METHYL-N,N-DIMETHYLTRYPTAMINE N-Methoxyphthalimide 4-Methoxybenzyl cyanide

N-(6-Methoxy-5-(2-methoxyphenoxy)-2-(pyridin-4-yl)-pyrimidin-4-yl)-5-methylpyridine-2-sulfonamide

N-(6-Methoxy-5-(2-methoxyphenoxy)-2-(pyridin-4-yl)-pyrimidin-4-yl)-5-methylpyridine-2-sulfonam

2-Pyridinesulfonamide,N-[6-methoxy-5-(2-methoxyphenoxy)-2-(4-pyridinyl)-4-pyrimidinyl]-5-methyl-

avosentan,CID 9912992

avosentan

N-[6-Methoxy-5-(2-methoxyphenoxy)-2-(4-pyridinyl)-4-pyrimidinyl]-5-methyl-2-pyridinesulfonamide

Ro 67-0565

SPP-301

Avosentan (SPP301)

RO 67-0565; SPP-301

Avosentan (Ro 67-0565

CS-644

inhibit,SPP 301,Inhibitor,Avosentan,SPP301,Endothelin Receptor

290815-26-8

C23H21N5O5S