ChemicalBook > CAS DataBase List > 4,5-Dichloro-7H-pyrrolo[2,3-d]pyrimidine

4,5-Dichloro-7H-pyrrolo[2,3-d]pyrimidine

Product Name: 4,5-Dichloro-7H-pyrrolo[2,3-d]pyrimidine
CAS No.: 115093-90-8
Chemical Name: 4,5-Dichloro-7H-pyrrolo[2,3-d]pyrimidine
Synonyms: 5-Chloro-4-chloro-7H-pyrr...;4,5-Dichloro-7H-pyrrolo[2,3-d]pyrimidine;4,5-dichloro-1H-pyrrolo[2,3-d]pyrimidine;7H-Pyrrolo[2,3-d]pyrimidine, 4,5-dichloro-;5-Chloro-4-chloro-7H-pyrrolo[2,3-d]pyrimidine
CBNumber: CB41509258
Molecular Formula: C6H3Cl2N3
Formula Weight: 188.01
MOL File: 115093-90-8.mol

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4,5-Dichloro-7H-pyrrolo[2,3-d]pyrimidine Property

Melting point:: 290 °C
Boiling point:: 220.9±50.0 °C(Predicted)
Density: 1.79±0.1 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
form: solid
pka: 9.52±0.20(Predicted)
color: White to off-white
InChI: InChI=1S/C6H3Cl2N3/c7-3-1-9-6-4(3)5(8)10-2-11-6/h1-2H,(H,9,10,11)
InChIKey: VFTPONHUNNOSKG-UHFFFAOYSA-N
SMILES: C1=NC(Cl)=C2C(Cl)=CNC2=N1

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Safety

HS Code: 2933998090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

AK Scientific

Product number: AMTH064
Product name: 4,5-Dichloro-7H-pyrrolo[2,3-d]pyrimidine
Packaging: 1g
Price: $20
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FD32770
Product name: 4,5-Dichloro-7H-pyrrolo[2,3-d]pyrimidine
Packaging: 250mg
Price: $60
Updated: 2021/12/16

Matrix Scientific

Product number: 068736
Product name: 4,5-Dichloro-7H-pyrrolo[2,3-d]pyrimidine
Purity: >95%
Packaging: 1g
Price: $73
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FD32770
Product name: 4,5-Dichloro-7H-pyrrolo[2,3-d]pyrimidine
Packaging: 500mg
Price: $100
Updated: 2021/12/16

SynQuest Laboratories

Product number: 3324-5-03
Product name: 4,5-Dichloro-7H-pyrrolo[2,3-d]pyrimidine
Packaging: 1g
Price: $125
Updated: 2021/12/16

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4,5-Dichloro-7H-pyrrolo[2,3-d]pyrimidine Chemical Properties,Usage,Production

Synthesis

3680-69-1

115093-90-8

GENERAL METHODS: 4-Chloropyrrolopyrimidine (20 mmol) was used as starting material, dissolved in N,N-dimethylformamide (DMF) (15 mL), followed by the addition of N-chlorosuccinimide (NCS) or N-bromosuccinimide (NBS) (21 mmol). The reaction mixture was stirred at room temperature for 72 hours. Upon completion of the reaction, ice water (150 mL) was slowly added to the mixture, precipitation was precipitated and the solid product was collected by filtration. The precipitate was washed with water (3 x 100 mL) and dried to give 4,5-dichloro-7H-pyrrolo[2,3-d]pyrimidine (3b) and possible by-products (3c).

References

[1] Synthesis, 2011, # 9, p. 1442 - 1446
[2] Archiv der Pharmazie, 2016, vol. 349, # 5, p. 356 - 362
[3] European Journal of Medicinal Chemistry, 2017, vol. 138, p. 543 - 551
[4] Patent: CN107556318, 2018, A. Location in patent: Paragraph 0101-0105
[5] Journal of Medicinal Chemistry, 1988, vol. 31, # 11, p. 2086 - 2092

4,5-Dichloro-7H-pyrrolo[2,3-d]pyrimidine Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 4,5-Dichloro-7H-pyrrolo[2,3-d]pyrimidine manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: 4,5-Dichloro-7H-pyrrolo[2,3-d]pyrimidine 115093-90-8
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20T
Release date: 2020-05-15

Career Henan Chemical Co

Product: 4,5-Dichloro-7H-pyrrolo[2,3-d]pyrimidine 115093-90-8
Price: US $0.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 150KG
Release date: 2019-07-01

115093-90-8, 4,5-Dichloro-7H-pyrrolo[2,3-d]pyrimidineRelated Search:

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