ChemicalBook > CAS DataBase List > 5-BROMO-6-CHLOROPYRAZIN-2-AMINE

5-BROMO-6-CHLOROPYRAZIN-2-AMINE

Product Name: 5-BROMO-6-CHLOROPYRAZIN-2-AMINE
CAS No.: 173253-42-4
Chemical Name: 5-BROMO-6-CHLOROPYRAZIN-2-AMINE
Synonyms: 132788;2-Amine-5-bromo-6-chloropyrazin;5-BROMO-6-CHLOROPYRAZIN-2-AMINE;5-Amino-2-bromo-3-chloropyrazine;2-AMINO-5-BROMO-6-CHLOROPYRAZINE;2-Pyrazinamine, 5-bromo-6-chloro-;5-Bromo-6-chloro-pyrazin-2-ylamine;5-BROMO-6-CHLOROPYRAZIN-2-AMINE ISO 9001：2015 REACH;2-Bromo-3-chloropyrazin-5-amine, 5-Bromo-6-chloropyrazin-2-amine, 3-Bromo-2-chloropyrazin-6-amine
CBNumber: CB41517590
Molecular Formula: C4H3BrClN3
Formula Weight: 208.44
MOL File: 173253-42-4.mol

Less

5-BROMO-6-CHLOROPYRAZIN-2-AMINE Property

Boiling point:: 311.8±37.0 °C(Predicted)
Density: 1.960
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
solubility: DMF: 25mg/mL,DMF:PBS (pH 7.2) (1:5): 0.16mg/mL,DMSO: 15mg/mL,Ethanol: 20mg/mL
form: A crystalline solid
pka: -0.67±0.10(Predicted)
Appearance: brown solid
InChI: InChI=1S/C4H3BrClN3/c5-3-4(6)9-2(7)1-8-3/h1H,(H2,7,9)
InChIKey: CRVPQFAORCSDMH-UHFFFAOYSA-N
SMILES: C1(N)=NC(Cl)=C(Br)N=C1

Less

Safety

Hazard Codes: T
Risk Statements: 25-37/38-41
Safety Statements: 26-39-45
RIDADR: 2811
WGK Germany: 3
HazardClass: 6.1
PackingGroup: Ⅲ
HS Code: 2933998090

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

H315Causes skin irritation

H318Causes serious eye damage

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Less

N-Bromosuccinimide Price

TRC

Product number: B696590
Product name: 5-Bromo-6-chloropyrazin-2-amine
Packaging: 500mg
Price: $90
Updated: 2021/12/16

AK Scientific

Product number: W3779
Product name: 2-Amino-5-bromo-6-chloropyrazine
Packaging: 25g
Price: $94
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB140487
Product name: 5-Bromo-6-chloropyrazin-2-amine
Packaging: 2g
Price: $95
Updated: 2021/12/16

AK Scientific

Product number: W3779
Product name: 2-Amino-5-bromo-6-chloropyrazine
Packaging: 1g
Price: $14
Updated: 2021/12/16

AK Scientific

Product number: W3779
Product name: 2-Amino-5-bromo-6-chloropyrazine
Packaging: 5g
Price: $34
Updated: 2021/12/16

Less

5-BROMO-6-CHLOROPYRAZIN-2-AMINE Chemical Properties,Usage,Production

Uses

5-Bromo-6-chloropyrazin-2-amine (Compound 110) is an organic compound used as an intermediate in the synthesis of various bioactive molecules. 5-Bromo-6-chloropyrazin-2-amine is promising for research of bacterial infections, such as tuberculosis[1].

Synthesis

33332-28-4

173253-42-4

General procedure for the synthesis of 2-amino-5-bromo-6-chloropyrazine from 2-amino-6-chloropyrazine: 6-chloropyrazin-2-amine (10.4 g, 80 mmol) was dissolved in methanol (300 mL), and N-bromosuccinimide (15.6 g, 88 mmol) was added slowly with stirring at room temperature. The reaction mixture was continued to stir for 60 min and then concentrated under reduced pressure to remove the solvent. Water was added to the concentrate and extracted with ethyl acetate (3 x 100 mL). The organic phases were combined, dried with anhydrous magnesium sulfate, filtered and concentrated under reduced pressure. The crude product was purified by silica gel column chromatography with the eluent being a solvent mixture of hashane and ethyl acetate (3:1, v/v) to afford the target compound 2-amino-5-bromo-6-chloropyrazine (12.0 g, 72% yield).1H NMR (500 MHz, CDCl3) δ 7.69 (s, 1H), 4.73 (s, 2H).

References

[1] Szychowski J, et al. Discovery of an orally bioavailable and selective PKMYT1 inhibitor, RP-6306[J]. Journal of medicinal chemistry, 2022, 65(15): 10251-10284.

5-BROMO-6-CHLOROPYRAZIN-2-AMINE Preparation Products And Raw materials

Raw materials

Preparation Products

Less

5-BROMO-6-CHLOROPYRAZIN-2-AMINE Suppliers

China 151 Germany 1 India 4 United Kingdom 2 United States 13 Global 171

Chengdu Novel Biomedical Co., Ltd.

Tel: 028-85255396 18302801538
Fax: 028-85255396
Email: cdnovell@163.com
Country: China
ProdList: 2389
Advantage: 58

Meryer (Shanghai) Chemical Technology Co., Ltd.

Tel: 4006356688 18621169109
Fax: 86-21-61259102
Email: market03@meryer.com
Country: China
ProdList: 40228
Advantage: 62

Energy Chemical

Tel: 021-021-58432009 400-005-6266
Fax: 021-58436166
Email: sales8178@energy-chemical.com
Country: China
ProdList: 44801
Advantage: 61

Capot Chemical Co., Ltd

Tel: +86 (0) 571 85 58 67 18
Fax: 0086-571-85864795
Country: China
ProdList: 18207
Advantage: 66

Jia Xing Isenchem Co.,Ltd

Tel: 0573-85285100 18627885956
Fax: 0573-85285100
Email: isenchem@163.com
Country: China
ProdList: 9310
Advantage: 66

ChengDu TongChuangYuan Pharmaceutical Co.Ltd

Tel: 28-83379370 13880556291
Fax: 028-87747383
Email: tcy@tcypharm.com
Country: China
ProdList: 510
Advantage: 57

Tetranov Biopharm

Tel: 13526569071
Email: sales@leadmedpharm.com
Country: China
ProdList: 7892
Advantage: 64

Accela ChemBio Co.,Ltd.

Tel: 021-50795510 4000665055
Fax: 021-50795055
Email: sales@accelachem.com
Country: China
ProdList: 11035
Advantage: 64

Shanghai Hanhong Scientific Co.,Ltd.

Tel: 021-54306202 13764082696
Email: info@hanhongsci.com
Country: China
ProdList: 42934
Advantage: 64

Shanghai Sunway Pharmaceutical Technology Co., Ltd

Tel: 18270980682
Fax: 021 51613951
Email: mlcheng@sunwaypharm.cn
Country: China
ProdList: 8669
Advantage: 57

Chengdu HappySyn Pharmaceutical Technology Co., Ltd.

Tel: 028-85114309 18982182443
Email: yangli@happysyn.com
Country: China
ProdList: 2150
Advantage: 55

Shanghai Xiannuo Biotechnology Co., Ltd.

Tel: 021-50718719 13918719472
Fax: 021-50718719
Country: China
ProdList: 979
Advantage: 58

Kohn & Shawn Pharmatech Co.,Ltd

Tel: 0931-4190454 13893344397
Fax: +86-931-8506154
Email: sales@kyxpharma.com
Country: China
ProdList: 310
Advantage: 55

Nanjing JinruiJiuAn Biotechnology Co., Ltd.

Tel: 025-58196018 800028039
Fax: 025-83453306
Email: sales@fartop.net
Country: China
ProdList: 2229
Advantage: 55

Shanghai T&W Pharmaceutical Co., Ltd.

Tel: +86 21 61551611
Fax: +86 21 50676805
Country: China
ProdList: 9891
Advantage: 58

Nanjing Norris-Pharm Technology Co., Ltd

Tel: 18652989687
Fax: +86-25-52131256
Email: sales@norris-pharm.com
Country: China
ProdList: 8878
Advantage: 55

Shanghai Yolne Chemical Co., Ltd.

Tel: 021-62960152
Fax: 021-52212593
Email: 934678158@qq.com
Country: China
ProdList: 9899
Advantage: 55

Shanghai Raise Chemical Technology Co.,Ltd

Tel: +86-021-50935922
Fax: +86-021-33847795
Country: China
ProdList: 7865
Advantage: 55

TargetMol Chemicals Inc.

Tel: 021-021-33632979 15002134094
Fax: 021-33632979
Email: marketing@targetmol.com
Country: China
ProdList: 7783
Advantage: 58

CEG Chemical Science&Technology Co., Ltd.

Tel: Mobile:13665161512
Fax: +86-510-68873513
Country: China
ProdList: 1785
Advantage: 58

Suzhou Sino Rare Chemical Co., Ltd.

Tel: 0512-62857507
Fax: +86-512-62857507
Email: sales@sinorarechem.com
Country: China
ProdList: 991
Advantage: 58

Bide Pharmatech Ltd.

Tel: 400-164-7117 13681763483
Fax: +86-21-61629029
Email: product02@bidepharm.com
Country: China
ProdList: 39966
Advantage: 60

Shanghai YuYuan Pharmaceutical Co., Ltd.

Tel: 13052276172
Fax: 13052276172
Email: product@yuyuanpharm.com
Country: China
ProdList: 493
Advantage: 55

Chemfun Medical Technology(Shanghai) Co., Ltd.

Tel: 021-67220633 021-54824098
Fax: +86-21-54824069
Email: chemfun@chemfun.net
Country: China
ProdList: 491
Advantage: 58

Shanghai HuanChuan Industry Co.,Ltd.

Tel: 021-61478794
Fax: 021-61478794
Email: sales@hcshhai.com
Country: China
ProdList: 9793
Advantage: 50

Nanjing Duolong Bio-tech Co.,Ltd.

Tel: 18905173768
Fax: 025-83263139
Email: 52513593@qq.com
Country: China
ProdList: 2331
Advantage: 50

Shanghai YuanQi Biotechnology Co., Ltd.

Tel: +86-2332782371 +86-18120098618
Email: sales@adobechem.com
Country: China
ProdList: 1250
Advantage: 50

Hangzhou Milestone Pharmtech Co., Ltd.

Tel: 0571-82896630 18969958410
Email: sales_hz@milestonepharmtech.com
Country: China
ProdList: 4894
Advantage: 55

Tongling HengYou Biotechnology Co., Ltd.

Tel: 021-50426030 13856289449
Fax: 021-50426030
Email: 2630597085@qq.com
Country: China
ProdList: 1889
Advantage: 55

JW & Y Pharmlab Co., Ltd.

Tel: 021-64340559 13651849907;
Fax: 021- 64345308
Email: xinyu_shi@jwypharmlab.com.cn
Country: China
ProdList: 12000
Advantage: 58

Zhengzhou Alfachem Co., Ltd.

Tel: 0371-53765687 18937137882
Fax: QQ:2885373884
Email: 2853979813@qq.com
Country: China
ProdList: 7991
Advantage: 55

Chengdu DingDang Pharmaceutical Co., Ltd.

Tel: 028-86040038 13980902949;
Fax: 028-85149890
Email: market@dingdangchem.com
Country: China
ProdList: 1853
Advantage: 55

Jinan SanZhi Pharmaceutical Technology Co., Ltd.

Tel: 15053191807
Fax: -
Email: sales_sanzhi@163.com
Country: China
ProdList: 286
Advantage: 55

Shanghai Qing Cang Chemical Technology Co., Ltd.

Tel: 00000000000
Fax: -
Email: sales@qingcangchem.com
Country: China
ProdList: 509
Advantage: 58

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 71826
Advantage: 60

parabiochem

Tel: 025-83453382-8005
Fax: 025-83453382
Email: sale@parabiochem.com
Country: China
ProdList: 9595
Advantage: 55

Suzhou JingTong Pharmaceutical Co., Ltd.

Tel: 13675155016
Fax: 18912765016
Email: tongtf110@sina.com
Country: China
ProdList: 963
Advantage: 55

ChengDu TongChuangYuan Pharmaceutical Co.Ltd

Tel: 028-83379370 13880556291
Fax: 028-87747383
Email: tcy@tcypharm.com
Country: China
ProdList: 7218
Advantage: 58

Shanghai Chaolan Chemical Technology Center

Tel: 021-QQ：65489617 15618227136
Fax: 21-5161 9052
Email: Sales@ATKchemical.com
Country: China
ProdList: 9125
Advantage: 58

Zhengzhou Acme Chemical Co., Ltd.

Tel: 0371-0371-55629727 13323845623
Fax: 037155629727
Email: 2885676761@qq.com
Country: China
ProdList: 10110
Advantage: 58

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131957
Advantage: 58

Adobe Chem Co., Ltd.

Tel: 2332782371
Fax: QQ: 2332782371
Email: adobechem@qq.com
Country: China
ProdList: 7980
Advantage: 58

Taian Jiaye Biotechnology Co.Ltd

Tel: 13127280945
Email: 285424065@qq.com
Country: China
ProdList: 9976
Advantage: 55

Wuxi KaideRui Pharmaceutical Technology Co., Ltd

Tel: 19906241957
Fax: -
Email: 1557216087@qq.com
Country: China
ProdList: 1837
Advantage: 55

Nanijing m&m biotechnology Co. ,Ltd.

Tel: 025-87782433 18021532344
Fax: 025-87782433
Email: 1345332203@qq.com
Country: China
ProdList: 4134
Advantage: 58

Shandong Ono Chemical Co., Ltd.

Tel: 0539-6362799 20）
Fax: 0539-6362799（To 20）
Country: China
ProdList: 9998
Advantage: 58

Hangzhou Molcore Biopharmatech Co.,Ltd

Tel: 400-711-5280 86-571-81025280
Fax: 86-571-85806285
Email: sales@molcore.com
Country: China
ProdList: 9967
Advantage: 58

Capot Chemical Co.,Ltd.

Tel: +86-（0）57185586718; +8613336195806
Fax: +86-571-85864795
Email: sales@capot.com
Country: China
ProdList: 29735
Advantage: 60

Aikon International Limited

Tel: 025-66113011 13155353615
Fax: (7)02557626880
Email: qzhang@aikonchem.com
Country: China
ProdList: 15394
Advantage: 58

Rhawn Reagent

Tel: 400-400-1332688 18019345275
Fax: 400-133-2688
Email: amy@rhawn.cn
Country: China
ProdList: 14948
Advantage: 58

Less

View Lastest Price from 5-BROMO-6-CHLOROPYRAZIN-2-AMINE manufacturers

Hong Kong Tiansheng New Material Trading Co., Ltd

Product: 5-Amino-2-bromo-3-chloropyrazine 173253-42-4
Price: US $3.90/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 10KG
Release date: 2021-09-24

Hong Kong Tiansheng New Material Trading Co., Ltd

Product: 2-Amino-5-bromo-6-chloropyrazine 173253-42-4
Price: US $3.90/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10kg
Release date: 2021-09-24

Hong Kong Tiansheng New Material Trading Co., Ltd

Product: 2-Amino-5-bromo-6-chloropyrazine 173253-42-4
Price: US $3.90/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 100KG
Release date: 2021-11-26

173253-42-4, 5-BROMO-6-CHLOROPYRAZIN-2-AMINERelated Search:

2-[1-(5-BROMO-6-CHLOROPYRAZIN-2-YL)PIPERIDIN-4-YL]-1H-ISOINDOLE-1,3(2H)-DIONE TERT-BUTYL [1-(5-BROMO-6-CHLOROPYRAZIN-2-YL)PIPERIDIN-4-YL]CARBAMATE 5-BROMO-6-CHLOROPYRAZIN-2-AMINE TERT-BUTYL 4-(5-BROMO-6-CHLOROPYRAZIN-2-YL)PIPERAZINE-1-CARBOXYLATE 5-BROMO-6-CHLORO-3-METHOXYPYRAZIN-2-AMINE 3,5-DIBROMO-6-CHLOROPYRAZIN-2-AMINE

5-BROMO-6-CHLOROPYRAZIN-2-AMINE

5-Amino-2-bromo-3-chloropyrazine

2-Bromo-3-chloropyrazin-5-amine, 5-Bromo-6-chloropyrazin-2-amine, 3-Bromo-2-chloropyrazin-6-amine

2-AMINO-5-BROMO-6-CHLOROPYRAZINE

5-Bromo-6-chloro-pyrazin-2-ylamine

132788

2-Amine-5-bromo-6-chloropyrazin

2-Pyrazinamine, 5-bromo-6-chloro-

5-BROMO-6-CHLOROPYRAZIN-2-AMINE ISO 9001：2015 REACH

173253-42-4

amine| alkyl bromide|alkyl chloride

Building Blocks

Chemical Synthesis

Heterocyclic Building Blocks

New Products for Chemical Synthesis

Pyrazines