3,5-DIBROMO-6-CHLOROPYRAZIN-2-AMINE

Product Name: 3,5-DIBROMO-6-CHLOROPYRAZIN-2-AMINE
CAS No.: 566205-01-4
Chemical Name: 3,5-DIBROMO-6-CHLOROPYRAZIN-2-AMINE
Synonyms: 3,5-DIBROMO-6-CHLORO-2-PYRAZINAMINE;3,5-DIBROMO-6-CHLOROPYRAZIN-2-AMINE;3,5-dibromo-6-chloro-2-aminopyrazine;2-Amino-3,5-dibromo-6-chloropyrazine;2-Pyrazinamine, 3,5-dibromo-6-chloro-
CBNumber: CB51517128
Molecular Formula: C4H2Br2ClN3
Formula Weight: 287.34
MOL File: 566205-01-4.mol

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3,5-DIBROMO-6-CHLOROPYRAZIN-2-AMINE Property

Boiling point:: 324.0±37.0 °C(Predicted)
Density: 1.237
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
pka: -1.51±0.10(Predicted)
Appearance: Off-white to light brown Solid

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC

Product number: D424660
Product name: 3,5-Dibromo-6-chloro-2-pyrazinamine
Packaging: 250mg
Price: $55
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FD153589
Product name: 3,5-Dibromo-6-chloro-2-pyrazinamine
Packaging: 500mg
Price: $70
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FD153589
Product name: 3,5-Dibromo-6-chloro-2-pyrazinamine
Packaging: 1g
Price: $125
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FD153589
Product name: 3,5-Dibromo-6-chloro-2-pyrazinamine
Packaging: 2g
Price: $213
Updated: 2021/12/16

Medical Isotopes, Inc.

Product number: 37739
Product name: 3,5-Dibromo-6-chloropyrazin-2-amine
Purity: 95+%
Packaging: 5G
Price: $630
Updated: 2021/12/16

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3,5-DIBROMO-6-CHLOROPYRAZIN-2-AMINE Chemical Properties,Usage,Production

Synthesis

33332-28-4

566205-01-4

Synthesis Example 1 Preparation of 2-amino-3,5-dibromo-6-chloropyrazine (4): To a solution of 2-amino-6-chloropyrazine (3) (8.00 g, 61.8 mmol) in acetonitrile (80 mL) was slowly added N-bromosuccinimide (NBS) (27.5 g, 155 mmol) at 0 °C. After addition, the reaction mixture was gradually warmed to room temperature and stirred overnight (18 hours). After completion of the reaction, water was added to the mixture and the product was extracted with ether (3 x 80 mL). The organic phases were combined and washed sequentially with water (1 x 80 mL) and saturated saline (1 x 80 mL), then dried over anhydrous sodium sulfate. After filtration, the filtrate was concentrated under reduced pressure and the resulting residue was purified by silica gel column chromatography (eluent: n-hexane/ethyl acetate= 3/1, v/v) to afford 2-amino-3,5-dibromo-6-chloropyrazine (4) (16.8 g, 58.5 mmol, 94.7% yield) as a yellow solid. tlc Rf = 0.31 (Expander: n-hexane/ethyl acetate= 4/1, v /v); 1H NMR (500MHz, CDCl3) δ 5.14 (s, 2H); 13C NMR (126MHz, CDCl3) δ 120.7, 122.0, 146.1, 151.0.

References

[1] Patent: US2012/232272, 2012, A1. Location in patent: Page/Page column 18
[2] Organic Letters, 2015, vol. 17, # 15, p. 3888 - 3891
[3] Patent: JP5837973, 2015, B2. Location in patent: Paragraph 0180; 0181
[4] Bulletin of the Korean Chemical Society, 2012, vol. 33, # 12, p. 4271 - 4274
[5] Patent: WO2014/29732, 2014, A1. Location in patent: Page/Page column 88

3,5-DIBROMO-6-CHLOROPYRAZIN-2-AMINE Preparation Products And Raw materials

Raw materials

Preparation Products

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3,5-DIBROMO-6-CHLOROPYRAZIN-2-AMINE Suppliers

China 71 India 1 United Kingdom 1 United States 7 Global 80

Carbott PharmTech Inc.

Tel: 0535-6385396
Fax: +86 (535) 638-9971
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Tetranov Biopharm

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Chiba Pharmaceutical Science and technology Co, Ltd.

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Advantage: 55

Nanjing Norris-Pharm Technology Co., Ltd

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Country: China
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SynAsst Chemical.

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Country: China
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Wuhan Kaymke Chemical Co., Ltd.,

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Advantage: 55

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Hangzhou Milestone Pharmtech Co., Ltd.

Tel: 0571-82896630 18969958410
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Accela ChemBio Inc.

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Shanghai Carlow Chemicals Co., Ltd.

Tel: 21-33526724 18930996265
Fax: +86 21 37023730
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Country: China
ProdList: 1969
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View Lastest Price from 3,5-DIBROMO-6-CHLOROPYRAZIN-2-AMINE manufacturers

Career Henan Chemical Co

Product: 3,5-DIBROMO-6-CHLOROPYRAZIN-2-AMINE 566205-01-4
Price: US $1.00/g
Min. Order: 1g
Purity: 98%
Supply Ability: 100KG
Release date: 2020-01-12

566205-01-4, 3,5-DIBROMO-6-CHLOROPYRAZIN-2-AMINERelated Search:

2-Pyridinecarboxaldehyde,3,5-dimethyl-(9CI) (3,5-DIFLUOROPYRIDIN-4-YL)BORONIC ACID 3,5-Dichloro-4-Methoxy-pyridine 3,5-DIAMINOBENZONITRILE 3,5-DIBROMO-4-PYRIDINOL 3,5-Dichloro-4-hydroxypyridine 3,5-Dichloro-2(1H)-pyrazinone ETHYL 3,5-DIBROMOISONICOTINATE 3,5-Difluoro-4-pyridinecarboxaldehyde 2-Pyridinecarboxylicacid,3,5-dimethyl-(9CI) 3,5-DIBROMO-4-METHOXYPYRIDINE-N-OXIDE 2-Amino-3-bromopyrazine 5-BROMO-6-CHLOROPYRAZIN-2-AMINE 2-Amino-3,5-dibromopyrazine 3,5-DIBROMO-6-CHLOROPYRAZIN-2-AMINE Aminopyrazine 2,6-Dibromopyrazine 5-BROMO-2-CHLOROPYRAZINE

3,5-DIBROMO-6-CHLOROPYRAZIN-2-AMINE

3,5-DIBROMO-6-CHLORO-2-PYRAZINAMINE

2-Amino-3,5-dibromo-6-chloropyrazine

3,5-dibromo-6-chloro-2-aminopyrazine

2-Pyrazinamine, 3,5-dibromo-6-chloro-

566205-01-4

C4H2Br2ClN3