ChemicalBook > CAS DataBase List > 5-BROMO-6-CHLOROPYRAZIN-2-AMINE

5-BROMO-6-CHLOROPYRAZIN-2-AMINE

Product Name
5-BROMO-6-CHLOROPYRAZIN-2-AMINE
CAS No.
173253-42-4
Chemical Name
5-BROMO-6-CHLOROPYRAZIN-2-AMINE
Synonyms
132788;2-Amine-5-bromo-6-chloropyrazin;5-BROMO-6-CHLOROPYRAZIN-2-AMINE;5-Amino-2-bromo-3-chloropyrazine;2-AMINO-5-BROMO-6-CHLOROPYRAZINE;2-Pyrazinamine, 5-bromo-6-chloro-;5-Bromo-6-chloro-pyrazin-2-ylamine;5-BROMO-6-CHLOROPYRAZIN-2-AMINE ISO 9001：2015 REACH;2-Bromo-3-chloropyrazin-5-amine, 5-Bromo-6-chloropyrazin-2-amine, 3-Bromo-2-chloropyrazin-6-amine
CBNumber
CB41517590
Molecular Formula
C4H3BrClN3
Formula Weight
208.44
MOL File
173253-42-4.mol
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5-BROMO-6-CHLOROPYRAZIN-2-AMINE Property

Boiling point:
311.8±37.0 °C(Predicted)
Density 
1.960
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
solubility 
DMF: 25mg/mL,DMF:PBS (pH 7.2) (1:5): 0.16mg/mL,DMSO: 15mg/mL,Ethanol: 20mg/mL
form 
A crystalline solid
pka
-0.67±0.10(Predicted)
Appearance
brown solid
InChI
InChI=1S/C4H3BrClN3/c5-3-4(6)9-2(7)1-8-3/h1H,(H2,7,9)
InChIKey
CRVPQFAORCSDMH-UHFFFAOYSA-N
SMILES
C1(N)=NC(Cl)=C(Br)N=C1
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Safety

Hazard Codes 
T
Risk Statements 
25-37/38-41
Safety Statements 
26-39-45
RIDADR 
2811
WGK Germany 
3
HazardClass 
6.1
PackingGroup 
Ⅲ
HS Code 
2933998090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

H315Causes skin irritation

H318Causes serious eye damage

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
B696590
Product name
5-Bromo-6-chloropyrazin-2-amine
Packaging
500mg
Price
$90
Updated
2021/12/16
AK Scientific
Product number
W3779
Product name
2-Amino-5-bromo-6-chloropyrazine
Packaging
25g
Price
$94
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB140487
Product name
5-Bromo-6-chloropyrazin-2-amine
Packaging
2g
Price
$95
Updated
2021/12/16
AK Scientific
Product number
W3779
Product name
2-Amino-5-bromo-6-chloropyrazine
Packaging
1g
Price
$14
Updated
2021/12/16
AK Scientific
Product number
W3779
Product name
2-Amino-5-bromo-6-chloropyrazine
Packaging
5g
Price
$34
Updated
2021/12/16
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5-BROMO-6-CHLOROPYRAZIN-2-AMINE Chemical Properties,Usage,Production

Uses

5-Bromo-6-chloropyrazin-2-amine (Compound 110) is an organic compound used as an intermediate in the synthesis of various bioactive molecules. 5-Bromo-6-chloropyrazin-2-amine is promising for research of bacterial infections, such as tuberculosis[1].

Synthesis

33332-28-4

173253-42-4

General procedure for the synthesis of 2-amino-5-bromo-6-chloropyrazine from 2-amino-6-chloropyrazine: 6-chloropyrazin-2-amine (10.4 g, 80 mmol) was dissolved in methanol (300 mL), and N-bromosuccinimide (15.6 g, 88 mmol) was added slowly with stirring at room temperature. The reaction mixture was continued to stir for 60 min and then concentrated under reduced pressure to remove the solvent. Water was added to the concentrate and extracted with ethyl acetate (3 x 100 mL). The organic phases were combined, dried with anhydrous magnesium sulfate, filtered and concentrated under reduced pressure. The crude product was purified by silica gel column chromatography with the eluent being a solvent mixture of hashane and ethyl acetate (3:1, v/v) to afford the target compound 2-amino-5-bromo-6-chloropyrazine (12.0 g, 72% yield).1H NMR (500 MHz, CDCl3) δ 7.69 (s, 1H), 4.73 (s, 2H).

References

[1] Szychowski J, et al. Discovery of an orally bioavailable and selective PKMYT1 inhibitor, RP-6306[J]. Journal of medicinal chemistry, 2022, 65(15): 10251-10284.

5-BROMO-6-CHLOROPYRAZIN-2-AMINE Preparation Products And Raw materials

Raw materials

Preparation Products

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5-BROMO-6-CHLOROPYRAZIN-2-AMINE Suppliers

China 151 Germany 1 India 4 United Kingdom 2 United States 13 Global 171
NovoChemy Ltd.
Tel
021-31261262/ 49 (0)17662837245
Fax
(0)21-33250524
Email
sales@novochemy.com
Country
Germany
ProdList
6328
Advantage
58
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View Lastest Price from 5-BROMO-6-CHLOROPYRAZIN-2-AMINE manufacturers

Hong Kong Tiansheng New Material Trading Co., Ltd
Product
5-Amino-2-bromo-3-chloropyrazine 173253-42-4
Price
US $3.90/KG
Min. Order
1KG
Purity
98%
Supply Ability
10KG
Release date
2021-09-24
Hong Kong Tiansheng New Material Trading Co., Ltd
Product
2-Amino-5-bromo-6-chloropyrazine 173253-42-4
Price
US $3.90/KG
Min. Order
1KG
Purity
99%
Supply Ability
10kg
Release date
2021-09-24
Hong Kong Tiansheng New Material Trading Co., Ltd
Product
2-Amino-5-bromo-6-chloropyrazine 173253-42-4
Price
US $3.90/KG
Min. Order
1KG
Purity
98%
Supply Ability
100KG
Release date
2021-11-26

173253-42-4, 5-BROMO-6-CHLOROPYRAZIN-2-AMINERelated Search:

2-[1-(5-BROMO-6-CHLOROPYRAZIN-2-YL)PIPERIDIN-4-YL]-1H-ISOINDOLE-1,3(2H)-DIONE TERT-BUTYL [1-(5-BROMO-6-CHLOROPYRAZIN-2-YL)PIPERIDIN-4-YL]CARBAMATE 5-BROMO-6-CHLOROPYRAZIN-2-AMINE TERT-BUTYL 4-(5-BROMO-6-CHLOROPYRAZIN-2-YL)PIPERAZINE-1-CARBOXYLATE 5-BROMO-6-CHLORO-3-METHOXYPYRAZIN-2-AMINE 3,5-DIBROMO-6-CHLOROPYRAZIN-2-AMINE

  • 5-BROMO-6-CHLOROPYRAZIN-2-AMINE
  • 5-Amino-2-bromo-3-chloropyrazine
  • 2-Bromo-3-chloropyrazin-5-amine, 5-Bromo-6-chloropyrazin-2-amine, 3-Bromo-2-chloropyrazin-6-amine
  • 2-AMINO-5-BROMO-6-CHLOROPYRAZINE
  • 5-Bromo-6-chloro-pyrazin-2-ylamine
  • 132788
  • 2-Amine-5-bromo-6-chloropyrazin
  • 2-Pyrazinamine, 5-bromo-6-chloro-
  • 5-BROMO-6-CHLOROPYRAZIN-2-AMINE ISO 9001：2015 REACH
  • 173253-42-4
  • amine| alkyl bromide|alkyl chloride
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