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12(S)-HPETE

Product Name
12(S)-HPETE
CAS No.
71774-10-2
Chemical Name
12(S)-HPETE
Synonyms
12(S)-HPETE;12(S)HpETE,12(S) HpETE;ZIOZYRSDNLNNNJ-LQWMCKPYSA-N;12(S)-HpETE Lipid Maps MS Standard;12(S)-Hydroperoxy-eicosatetraenoic acid;(12S)-12-hydroperoxyicosa-5,8,10,14-tetraenoic acid;12S-HYDROPEROXY-5Z,8Z,10E,14Z-EICOSATETRAENOIC ACID;12(S)-HYDROPEROXYEICOSA-5Z,8Z,10E,14Z-TETRAENOIC ACID;(5Z,8Z,10E,12S,14Z)-12-Hydroperoxyicosa-5,8,10,14-tetraenoic acid;(5Z,8Z,10E,12S,14Z)-12-Hydroperoxy-5,8,10,14-icosatetraenoic acid
CBNumber
CB4154161
Molecular Formula
C20H32O4
Formula Weight
336.47
MOL File
71774-10-2.mol
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12(S)-HPETE Property

Boiling point:
518.0±50.0 °C(Predicted)
Density 
1.013±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
0.1 M Na2CO3: 2 mg/ml; DMF: Miscible; DMSO: Miscible; Ethanol: Miscible; PBS pH 7.2: 0.8 mg/ml
form 
Liquid.
pka
4.75±0.10(Predicted)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H225Highly Flammable liquid and vapour

H319Causes serious eye irritation

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P233Keep container tightly closed.

P240Ground/bond container and receiving equipment.

P241Use explosion-proof electrical/ventilating/lighting/…/equipment.

P242Use only non-sparking tools.

P243Take precautionary measures against static discharge.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P337+P313IF eye irritation persists: Get medical advice/attention.

P370+P378In case of fire: Use … for extinction.

P403+P235Store in a well-ventilated place. Keep cool.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical
Product number
44570
Product name
12(S)-HpETE
Purity
≥98%
Packaging
25μg
Price
$131
Updated
2024/03/01
Cayman Chemical
Product number
44570
Product name
12(S)-HpETE
Purity
≥98%
Packaging
50μg
Price
$246
Updated
2024/03/01
Cayman Chemical
Product number
44570
Product name
12(S)-HpETE
Purity
≥98%
Packaging
100μg
Price
$466
Updated
2024/03/01
Cayman Chemical
Product number
44570
Product name
12(S)-HpETE
Purity
≥98%
Packaging
250μg
Price
$1030
Updated
2024/03/01
TRC
Product number
H456410
Product name
12(S)-HPETE
Packaging
50μg
Price
$225
Updated
2021/12/16
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12(S)-HPETE Chemical Properties,Usage,Production

Description

12(S)-HpETE is a monohydroperoxy polyunsaturated fatty acid (PUFA) produced by the action of platelet or leukocyte 12-lipoxygenase (12-LO) on arachidonic acid. It activates human blood leukocyte 5-LO, resulting in the synthesis of 5(S)-HETE, leukotriene B4 (LTB4), and 5(S),12(S)-DiHETE. Rat lung metabolizes 12(S)-HpETE to 8,11,12- and 10,11,12-trihydroxyeicostrienoic acids. 12(S)-HpETE is the mediator of many biological functions, including induction of c-fos and c-jun, activation of AP-1, and endothelium-dependent vasoconstriction. It mediates the inhibitory synaptic response to FMRF-amide in Aplysia sensory neurons and inhibits Ca2+/calmodulin-dependent protein kinase II from rat brain cortex.

Uses

12(S)-HPETE is a fatty acid and an activator of human blood leukocyte 5-LO.

Definition

ChEBI: 12(S)-HPETE is the (S)-enantiomer of 12-HPETE. It has a role as a mouse metabolite. It is functionally related to an icosa-5,8,10,14-tetraenoic acid. It is a conjugate acid of a 12(S)-HPETE(1-). It is an enantiomer of a 12(R)-HPETE.

12(S)-HPETE Preparation Products And Raw materials

Raw materials

Preparation Products

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12(S)-HPETE Suppliers

China 23 Switzerland 1 United Kingdom 1 United States 3 Global 28

71774-10-2, 12(S)-HPETERelated Search:

12(S)-HPETE LIPID MAPS 12(S)-HPETE [1-14C] 12(R)-HPETE (+/-)12-HPETE 12(S)-HPETE (+/-)12-HETE 12(S)-HETE 1,5-HEPTADIEN-4-OL 1.3.7-OCTATRIENE

  • 12S-HYDROPEROXY-5Z,8Z,10E,14Z-EICOSATETRAENOIC ACID
  • 12(S)-HYDROPEROXYEICOSA-5Z,8Z,10E,14Z-TETRAENOIC ACID
  • 12(S)-HPETE
  • (12S)-12-hydroperoxyicosa-5,8,10,14-tetraenoic acid
  • (5Z,8Z,10E,12S,14Z)-12-Hydroperoxy-5,8,10,14-icosatetraenoic acid
  • (5Z,8Z,10E,12S,14Z)-12-Hydroperoxyicosa-5,8,10,14-tetraenoic acid
  • 12(S)-Hydroperoxy-eicosatetraenoic acid
  • (5Z,8Z,10Z,12S,14Z)-12-Hydroperoxy-5,8,10,14-icosatetraenoic acid
  • 12(S)-HpETE Lipid Maps MS Standard
  • ZIOZYRSDNLNNNJ-LQWMCKPYSA-N
  • 12(S)HpETE,12(S) HpETE
  • 5,8,10,14-Eicosatetraenoic acid, 12-hydroperoxy-, (5Z,8Z,10E,12S,14Z)-
  • 71774-10-2