(2-Trifluoromethyl-pyridin-4-yl)-methanol
- Product Name
- (2-Trifluoromethyl-pyridin-4-yl)-methanol
- CAS No.
- 131747-61-0
- Chemical Name
- (2-Trifluoromethyl-pyridin-4-yl)-methanol
- Synonyms
- 2-(TrifluoroMethyl)-4-pyridineMethanol;2-(Trifluoromethyl)pyridine-4-methanol;[2-(trifluoromethyl)-4-pyridyl]methanol;4-PyridineMethanol, 2-(trifluoroMethyl)-;(2-Trifluoromethyl-pyridin-4-yl)-methanol;4-(Hydroxymethyl)-2-(trifluoromethyl)pyridine;4-(Hydroxymethyl)-2-(trifluoromethyl)pyridine 95%;[2-(Trifluoromethyl)pyridin-4-yl]methanol, 2-(Trifluoromethyl)isonicotinyl alcohol
- CBNumber
- CB41553842
- Molecular Formula
- C7H6F3NO
- Formula Weight
- 177.12
- MOL File
- 131747-61-0.mol
(2-Trifluoromethyl-pyridin-4-yl)-methanol Property
- Boiling point:
- 212.6±35.0 °C(Predicted)
- Density
- 1.362±0.06 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Room Temperature
- pka
- 13.13±0.10(Predicted)
- form
- liquid
- color
- Colourless
- InChI
- InChI=1S/C7H6F3NO/c8-7(9,10)6-3-5(4-12)1-2-11-6/h1-3,12H,4H2
- InChIKey
- UOQWDROTEICSEX-UHFFFAOYSA-N
- SMILES
- C1(C(F)(F)F)=NC=CC(CO)=C1
Safety
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H317May cause an allergic skin reaction
H319Causes serious eye irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- PC49314
- Product name
- 4-(Hydroxymethyl)-2-(trifluoromethyl)pyridine
- Purity
- 95%
- Packaging
- 500mg
- Price
- $221
- Updated
- 2021/12/16
- Product number
- 4H01-3-W5
- Product name
- 4-(Hydroxymethyl)-2-(trifluoromethyl)pyridine
- Packaging
- 500mg
- Price
- $244
- Updated
- 2021/12/16
- Product number
- T14095
- Product name
- [2-(Trifluoromethyl)pyridin-4-yl]methanol
- Packaging
- 1g
- Price
- $300
- Updated
- 2021/12/16
- Product number
- PC49314
- Product name
- 4-(Hydroxymethyl)-2-(trifluoromethyl)pyridine
- Purity
- 95%
- Packaging
- 250mg
- Price
- $122
- Updated
- 2021/12/16
- Product number
- 4H01-3-W5
- Product name
- 4-(Hydroxymethyl)-2-(trifluoromethyl)pyridine
- Packaging
- 250mg
- Price
- $135
- Updated
- 2021/12/16
(2-Trifluoromethyl-pyridin-4-yl)-methanol Chemical Properties,Usage,Production
Synthesis
131747-41-6
131747-61-0
General procedure for the synthesis of (2-trifluoromethyl-pyridin-4-yl)-methanol from 2-(trifluoromethyl)isonicotinic acid: 2-(trifluoromethyl)isonicotinic acid (10.0 g, 52.4 mmol) was dissolved in tetrahydrofuran (150 mL) and cooled down to 0 °C. Under nitrogen protection, 1 mol/L borane-tetrahydrofuran solution (105 mL, 105 mmol) was slowly added. The reaction mixture was heated to 75 °C and the reaction was stirred for 2 hours. After completion of the reaction, the mixture was carefully poured into ice water and extracted with ethyl acetate. The organic layer was washed with saturated brine and dried over anhydrous sodium sulfate. The desiccant was removed by filtration and the filtrate was concentrated under reduced pressure. The resulting crude product was purified by silica gel column chromatography (eluent: hexane/ethyl acetate) to afford the target product (2-trifluoromethyl-pyridin-4-yl)-methanol (5.60 g, 31.6 mmol, 60% yield). Mass spectrum (ESI) m/z: 178 ([M+H]+). 1H NMR (300 MHz, CDCl3): δ 8.68 (d, J=4.8Hz, 1H), 7.79 (s, 1H), 7.64 (d, J=4.8Hz, 1H), 5.62 (br-s, 1H), 4.66 (s, 2H).
References
[1] Patent: US2016/332999, 2016, A1. Location in patent: Paragraph 0775; 0776; 0777; 0778
[2] Chemical and Pharmaceutical Bulletin, 1990, vol. 38, # 9, p. 2446 - 2458
[3] Patent: WO2015/138220, 2015, A1. Location in patent: Page/Page column 69
[4] Patent: WO2016/29454, 2016, A1. Location in patent: Page/Page column 59
(2-Trifluoromethyl-pyridin-4-yl)-methanol Preparation Products And Raw materials
Raw materials
Preparation Products
(2-Trifluoromethyl-pyridin-4-yl)-methanol Suppliers
- Tel
- 18796480679 15295163861
- 3844328290@qq.com
- Country
- China
- ProdList
- 602
- Advantage
- 58
- Tel
- 18210857532; 18210857532
- Fax
- 86-10-82849933
- jkinfo@jkchemical.com
- Country
- China
- ProdList
- 96815
- Advantage
- 76
- Tel
- 0519-89803565 13776850645
- Fax
- 0519-89803575
- info4@huanlingchem.com
- Country
- China
- ProdList
- 891
- Advantage
- 68
- Tel
- 0573-85285100 18627885956
- Fax
- 0573-85285100
- isenchem@163.com
- Country
- China
- ProdList
- 9310
- Advantage
- 66
- Tel
- 025-83697070
- Fax
- +86-25-83453306
- info@chemlin.com.cn
- Country
- China
- ProdList
- 15883
- Advantage
- 64
- Tel
- 150-2103-5486 18017383231
- Fax
- qq：2817624287
- 983544897@qq.com
- Country
- China
- ProdList
- 9342
- Advantage
- 55
- Tel
- 021-60343070
- Fax
- 021-35122006
- Country
- China
- ProdList
- 12740
- Advantage
- 55
- Tel
- 13661494087 18964793018
- Fax
- 86-021-51821718 QQ：2427604606
- sales@mof-chemicals.com
- Country
- China
- ProdList
- 293
- Advantage
- 55
- Tel
- 029-86115547 17791676824
- Fax
- 02151602123
- sales@cochemical.com
- Country
- China
- ProdList
- 3014
- Advantage
- 58
- Tel
- 021-61317773
- Fax
- 021-61486878
- sales@aspirebio.com
- Country
- China
- ProdList
- 2880
- Advantage
- 58
View Lastest Price from (2-Trifluoromethyl-pyridin-4-yl)-methanol manufacturers
- Product
- (2-Trifluoromethyl-pyridin-4-yl)-methanol 131747-61-0
- Price
- US $6.68/KG
- Min. Order
- 1KG
- Purity
- 97%-99%
- Supply Ability
- 1kg-1000kg
- Release date
- 2020-01-10